Catalog No.
YHN49301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn831-Phe995
Predicted molecular weight
21.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q75QN2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Integrator complex subunit 8, Int8, Protein kaonashi-1, C8orf52, INTS8
CRL3ARMC5 ubiquitin ligase and Integrator phosphatase form parallel mechanisms to control early stages of RNA Pol II transcription., PMID:39667934
Comprehensive bioinformatics analysis of integrator complex subunits: expression patterns, immune infiltration, and prognostic signature, validated through experimental approaches in hepatocellular carcinoma., PMID:38926181
Integrative analysis of miRNA-mRNA expression in the brain during high temperature-induced masculinization of female Nile tilapia (Oreochromis niloticus)., PMID:38734154
Protocol for rapidly inducing genome-wide RNA Pol II hyperphosphorylation by selectively disrupting INTAC phosphatase activity., PMID:37831607
Meta-Analysis of EGF-Stimulated Normal and Cancer Cell Lines to Discover EGF-Associated Oncogenic Signaling Pathways and Prognostic Biomarkers., PMID:36381277
An Integrated Analysis of Prognostic Signature and Immune Microenvironment in Tongue Squamous Cell Carcinoma., PMID:35912229
INTS8 is a therapeutic target for intrahepatic cholangiocarcinoma via the integration of bioinformatics analysis and experimental validation., PMID:34880328
Mining Complex Genetic Patterns Conferring Multiple Sclerosis Risk., PMID:33802599
Integrated Analysis of the Prognosis-Associated RNA-Binding Protein Genes and Candidate Drugs in Renal Papillary Cell Carcinoma., PMID:33643390
Structure of the catalytic core of the Integrator complex., PMID:33548203
Genome-wide DNA methylation analysis of cognitive function in middle and old-aged Chinese monozygotic twins., PMID:33131831
Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination., PMID:32966759
Biallelic INTS1 Mutations Cause a Rare Neurodevelopmental Disorder in Two Chinese Siblings., PMID:31428919
The Integrator Complex Prevents Dedifferentiation of Intermediate Neural Progenitors back into Neural Stem Cells., PMID:31018143
A pan-cancer study of copy number gain and up-regulation in human oncogenes., PMID:30243646
Human mutations in integrator complex subunits link transcriptome integrity to brain development., PMID:28542170
Pan-Cancer Mutational and Transcriptional Analysis of the Integrator Complex., PMID:28468258
Microarray-based identification of genes associated with cancer progression and prognosis in hepatocellular carcinoma., PMID:27567667
Concurrent Mutations in ATM and Genes Associated with Common γ Chain Signaling in Peripheral T Cell Lymphoma., PMID:26536348
A 4-gene panel as a marker at chromosome 8q in Asian gastric cancer patients., PMID:23722107
For research use only. Not for human or drug use.
