Catalog No.
YHN48801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg17-Gly141
Predicted molecular weight
16.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9H0M0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NEDD4-like E3 ubiquitin-protein ligase WWP1, 2.3.2.26, Atrophin-1-interacting protein 5, AIP5, HECT-type E3 ubiquitin transferase WWP1, TGIF-interacting ubiquitin ligase 1, Tiul1, WW domain-containing protein 1, WWP1
Estradiol inhibits endometrial injury by promoting the stability of the KLF15 protein and the recovery of mitochondrial function., PMID:40513792
[WW domain-containing ubiquitin E3 ligase 1 regulates immune infiltration in tumor microenvironment of ovarian cancer]., PMID:40415439
Depletion of WWP1 Increases Adrb3 Expression and Lipolysis in White Adipose Tissue of Obese Mice., PMID:40362456
YY1 induced USP13 transcriptional activation drives the malignant progression of hepatocellular carcinoma by deubiquitinating WWP1., PMID:40319251
WWP1-SHARP1-C/EBPβ positive feedback loop modulates development of metabolic dysfunction-associated steatotic liver disease., PMID:40280477
WWP1 mediates the ubiquitination and degradation of HIPK3 in bladder cancer cells., PMID:40280416
HSP90 regulates dCK stability and inhibits ionizing radiation-induced ferroptosis in cervical cancer cells., PMID:40263268
P53 Puzzle: WWP1 and PARC Immunohistochemistry Illuminate New Pathways for Serous Ovarian Cancer., PMID:40248870
Bioinformatics analysis of oxidative phosphorylation-related differentially expressed genes in osteoporosis., PMID:40241169
Portrait of WWP1: the current state in human cancer., PMID:39949609
[WWP1 plays a positive role in ameloblast differentiation and enamel formation in mice]., PMID:39743363
WWP1 inhibition suppresses the proliferation of pancreatic cancer cells by regulating the PI3K-AKT pathway., PMID:39656237
WWP1 targeting PTEN for polyubiquitination to promote bone metastasis of luminal breast cancer., PMID:39622957
The effects of WWP1 overexpression on the golgi apparatus stress response and proteoglycan production in adipocytes., PMID:39578509
GPRC5A promotes lung colonization of esophageal squamous cell carcinoma., PMID:39550386
N-butanol extract of Broussonetia papyrifera (L.) L'Hér. ex Vent root bark alleviates atopic dermatitis by targeting E3 ubiquitin ligase WWP1 to promote NLRP3 degradation., PMID:39405906
Thioredoxin-interacting protein (TXNIP) is a substrate of the NEDD4-like E3 ubiquitin-protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells., PMID:39364720
Expanding the inhibitor space of the WWP1 and WWP2 HECT E3 ligases., PMID:39223706
Presynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated Ca2+ channels., PMID:39172783
CYYR1 promotes the degradation of the E3 ubiquitin ligase WWP1 and is associated with favorable prognosis in breast cancer., PMID:39059493
Gallium complex K6 inhibits colorectal cancer by increasing ROS levels to induce DNA damage and enhance phosphatase and tensin homolog activity., PMID:39049965
WWP1 inhibition increases SHP2 inhibitor efficacy in colorectal cancer., PMID:39014007
Extrachromosomal circular DNA promotes prostate cancer progression through the FAM84B/CDKN1B/MYC/WWP1 axis., PMID:38997648
Exosomal miR-17-5p derived from epithelial cells is involved in aberrant epithelium-fibroblast crosstalk and induces the development of oral submucosal fibrosis., PMID:38897993
Immunohistochemical Expression and Clinical Significance of WWP1 Protein in Nasopharyngeal Cancer., PMID:38804681
The R436Q missense mutation in WWP1 disrupts autoinhibition of its E3 ubiquitin ligase activity, leading to self-degradation and loss of function., PMID:38561589
The role of WWP1 and WWP2 in bone/cartilage development and diseases., PMID:38252355
WWP1 E3 ligase at the crossroads of health and disease., PMID:38129384
Biomimetic composite hydrogel promotes new bone formation in rat bone defects through regulation of miR-19b-3p/WWP1 axis by loaded extracellular vesicles., PMID:38037135
Molecular mechanism of WWP1-mediated ubiquitination modification affecting proliferation and invasion/migration of liver cancer cells., PMID:37997542
Modulation of Krüppel-like factors (KLFs) interaction with their binding partners in cancers through acetylation and phosphorylation., PMID:37992989
LINC02253 promote the malignant phenotype of Colon adenocarcinoma cells by up-regulating WWP1-mediated SMAD3 ubiquitination., PMID:37597669
Cruciferous vegetable-derived indole-3-carbinol prevents coronavirus cell egression mechanisms in tracheal and intestinal 3D in vitro models., PMID:37169138
Systemic depletion of WWP1 improves insulin sensitivity and lowers triglyceride content in the liver of obese mice., PMID:37032433
PGNneo: A Proteogenomics-Based Neoantigen Prediction Pipeline in Noncoding Regions., PMID:36899918
The E3 ubiquitin ligases regulate inflammation in cardiovascular diseases., PMID:36872193
ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold., PMID:36168627
The effects of β-catenin on cardiomyogenesis via Islet-1 and MLIP ubiquitination., PMID:36112854
Bone marrow mesenchymal stem cell-derived extracellular vesicles facilitate endometrial injury repair by carrying the E3 ubiquitin ligase WWP1., PMID:36043683
LncRNA nuclear-enriched abundant transcript 1 aggravates cerebral ischemia/reperfusion injury through activating early growth response-1/RNA binding motif protein 25 axis., PMID:35997641
Attenuation of HECT-E3 ligase expression rescued memory deficits in 3xTg-AD mice., PMID:35966798
E2UbcH5B-derived peptide ligands target HECT E3-E2 binding site and block the Ub-dependent SARS-CoV-2 egression: A computational study., PMID:35751189
Identification of healthspan-promoting genes in Caenorhabditis elegans based on a human GWAS study., PMID:35748965
YTHDF1 alleviates sepsis by upregulating WWP1 to induce NLRP3 ubiquitination and inhibit caspase-1-dependent pyroptosis., PMID:35508474
Research progress of Nedd4L in cardiovascular diseases., PMID:35429991
WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma., PMID:35264565
α-Catulin promotes cancer stemness by antagonizing WWP1-mediated KLF5 degradation in lung cancer., PMID:35154481
Dysregulation of the miR-16-WWP1 signalling pathway leads to colorectal tumorigenesis., PMID:35083873
Transcriptome Analysis of Large to Giant Congenital Melanocytic Nevus Reveals Cell Cycle Arrest and Immune Evasion: Identifying Potential Targets for Treatment., PMID:34912899
WWP1 inactivation enhances efficacy of PI3K inhibitors while suppressing their toxicities in breast cancer models., PMID:34907909
For research use only. Not for human or drug use.
