Catalog No.
YHN48401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg122-Gln254
Predicted molecular weight
17.74 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96CS3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FAS-associated factor 2, Protein ETEA, UBX domain-containing protein 3B, UBX domain-containing protein 8, FAF2, ETEA, KIAA0887, UBXD8, UBXN3B
Silencing FAF2 mitigates alcohol-induced hepatic steatosis by modulating lipolysis and PCSK9 pathway., PMID:39969435
Quality control of ABCD3 by the VCP-FAF2 complex suppresses excessive pexophagy., PMID:39929145
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma., PMID:39820491
VCP regulates early tau seed amplification via specific cofactors., PMID:39773263
FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses., PMID:39763943
AAA+ ATPase chaperone p97/VCPFAF2 governs basal pexophagy., PMID:39472561
VCP regulates early tau seed amplification via specific cofactors., PMID:38826306
The balance between antiviral and antibacterial responses during M. tuberculosis infection is regulated by the ubiquitin ligase CBL., PMID:38798543
Exploring KRAS-mutant pancreatic ductal adenocarcinoma: a model validation study., PMID:38268915
Featured interactome of homocysteine-inducible endoplasmic reticulum protein uncovers novel binding partners in response to ER stress., PMID:37736299
VCP increases or decreases tau seeding using specific cofactors., PMID:37693404
SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage., PMID:37223481
Pathogenesis of Alcohol-Associated Liver Disease., PMID:36340300
Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma., PMID:35995997
Multiple UBX proteins reduce the ubiquitin threshold of the mammalian p97-UFD1-NPL4 unfoldase., PMID:35920641
Activation of E6AP/UBE3A-Mediated Protein Ubiquitination and Degradation Pathways by a Cyclic γ-AA Peptide., PMID:35045253
SARS-COV-2 Coronavirus Papain-like Protease PLpro as an Antiviral Target for Inhibitors of Active Site and Protein-Protein Interactions., PMID:36883182
Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner., PMID:34739333
Altered stress granule disassembly: links to neurodegenerative disease?, PMID:34429216
EVI/WLS function is regulated by ubiquitylation and is linked to ER-associated degradation by ERLIN2., PMID:34406391
Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis., PMID:34078402
Identification of novel prognostic genes of triple-negative breast cancer using meta-analysis and weighted gene co-expressed network analysis., PMID:33708832
The GTPase ARFRP1 affects lipid droplet protein composition and triglyceride release from intracellular storage of intestinal Caco-2 cells., PMID:30348522
UBXN3B positively regulates STING-mediated antiviral immune responses., PMID:29899553
Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer., PMID:29263404
Haploid Mammalian Genetic Screen Identifies UBXD8 as a Key Determinant of HMGCR Degradation and Cholesterol Biosynthesis., PMID:28882874
In focus in HCB., PMID:28721451
Hepatocyte-specific depletion of ubiquitin regulatory X domain containing protein 8 accelerates fibrosis in a mouse non-alcoholic steatohepatitis model., PMID:28421320
The opposite role of two UBA-UBX containing proteins, p47 and SAKS1 in the degradation of a single ERAD substrate, α-TCR., PMID:27785701
Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains., PMID:27295553
[Effects of microRNA-146a on Fas-associated factor 2 and inflammatory factors in human lung adenocarcinoma A549 cells under the stimulation of cigarette smoke extract]., PMID:26902276
The CLAVATA signaling pathway mediating stem cell fate in shoot meristems requires Ca(2+) as a secondary cytosolic messenger., PMID:26756833
Cellular responses to excess fatty acids: focus on ubiquitin regulatory X domain-containing protein 8., PMID:24378746
Pathogenic mutation of UBQLN2 impairs its interaction with UBXD8 and disrupts endoplasmic reticulum-associated protein degradation., PMID:24215460
Triglyceride-rich lipoproteins and cytosolic lipid droplets in enterocytes: key players in intestinal physiology and metabolic disorders., PMID:23871915
UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids., PMID:23720822
A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation., PMID:23665563
Protein segregase meddles in remodeling of mRNA-protein complexes., PMID:23651853
The p97-UBXD8 complex destabilizes mRNA by promoting release of ubiquitinated HuR from mRNP., PMID:23618873
Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover., PMID:23297223
The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis., PMID:22454508
Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets., PMID:22238364
The FANTASTIC FOUR proteins influence shoot meristem size in Arabidopsis thaliana., PMID:21176196
Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis., PMID:21115839
The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans., PMID:20160012
Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients., PMID:12372427
For research use only. Not for human or drug use.
