Catalog No.
YHN48101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg21-Arg110
Predicted molecular weight
23.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7RTV0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PHD finger-like domain-containing protein 5A, PHD finger-like domain protein 5A, Splicing factor 3B-associated 14 kDa protein, SF3b14b, PHF5A
Analysis and exploration of regulatory mechanisms and potential prognostic biomarkers in squamous cell carcinoma of the lung by expression profiling., PMID:39974402
Structure-Activity Relationship Study of Splicing Modulators on Hsh155/SF3B1 through Chemical Synthesis and Yeast Genetics., PMID:39691513
Splicing control by PHF5A is crucial for melanoma cell survival., PMID:39212334
Comprehensive analysis of PHF5A as a potential prognostic biomarker and therapeutic target across cancers and in hepatocellular carcinoma., PMID:39030507
PHF5A promotes esophageal squamous cell carcinoma progression via stabilizing VEGFA., PMID:38429756
Spliceosome component PHD finger 5A is essential for early B lymphopoiesis., PMID:38095286
In-depth analyses of lncRNA and circRNA expression in the hippocampus of LPS-induced AD mice by Byu d Mar 25., PMID:38051653
Plant homeodomain-finger protein 5A: A key player in cancer progression., PMID:37951028
Synthesis and Conformational Analysis of FR901464-Based RNA Splicing Modulators and Their Synergism in Drug-Resistant Cancers., PMID:37870431
PHF5A is a potential diagnostic, prognostic, and immunological biomarker in pan-cancer., PMID:37845358
KMT2A associates with PHF5A-PHF14-HMG20A-RAI1 subcomplex in pancreatic cancer stem cells and epigenetically regulates their characteristics., PMID:37709746
PHF5A as a new OncoTarget and therapeutic prospects., PMID:37483794
PHF5A regulates the expression of the DOCK5 variant to promote HNSCC progression through p38 MAPK activation., PMID:37434235
De novo PHF5A variants are associated with craniofacial abnormalities, developmental delay, and hypospadias., PMID:37422718
[PHF5A Promotes Proliferation and Migration of Non-Small Cell Lung Cancer
by Regulating of PI3K/AKT Pathway]., PMID:36792075
The phosphorylation of PHF5A by TrkA-ERK1/2-ABL1 cascade regulates centrosome separation., PMID:36759599
PHF5A facilitates the development and progression of gastric cancer through SKP2-mediated stabilization of FOS., PMID:36609277
Research progress and therapeutic prospect of PHF5A acting as a new target for malignant tumors., PMID:36581580
Effects of exogenous melatonin on expressional differences of immune-related genes in cashmere goats., PMID:36353099
PHF5A Contributes to the Maintenance of the Cancer Stem-like Phenotype in Non-Small Cell Lung Cancer by Regulating Histone Deacetylase 8., PMID:35777798
Construction and Validation of Prognostic Regulation Network Based on RNA-Binding Protein Genes in Lung Squamous Cell Carcinoma., PMID:34931870
SIRT7-Induced PHF5A Decrotonylation Regulates Aging Progress Through Alternative Splicing-Mediated Downregulation of CDK2., PMID:34604215
Enterotoxigenic Bacteroidesfragilis Promotes Intestinal Inflammation and Malignancy by Inhibiting Exosome-Packaged miR-149-3p., PMID:34371001
Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors., PMID:34301950
Overlapping roles of spliceosomal components SF3B1 and PHF5A in rice splicing regulation., PMID:33953336
Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition., PMID:33938017
Whole-exome sequencing analysis in 10 families of sporadic microtia with thoracic deformities., PMID:33811463
The SF3b Complex is an Integral Component of the Spliceosome and Targeted by Natural Product-Based Inhibitors., PMID:33252738
RNA Polymerase II-Associated Factor 1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions With PHF5A and DDX3., PMID:32781084
CHD4 mediates proliferation and migration of non-small cell lung cancer via the RhoA/ROCK pathway by regulating PHF5A., PMID:32228507
Exploiting Cryo-EM Structural Information and All-Atom Simulations To Decrypt the Molecular Mechanism of Splicing Modulators., PMID:31539251
Acetylation of PHF5A Modulates Stress Responses and Colorectal Carcinogenesis through Alternative Splicing-Mediated Upregulation of KDM3A., PMID:31054974
PHD finger protein 5A promoted lung adenocarcinoma progression via alternative splicing., PMID:30932358
Knockdown of PHF5A Inhibits Migration and Invasion of HCC Cells via Downregulating NF-κB Signaling., PMID:30766880
Cancer Stem Cell based molecular predictors of tumor recurrence in Oral squamous cell carcinoma., PMID:30641296
Transcriptome profiling of human oocytes experiencing recurrent total fertilization failure., PMID:30559372
MBNL1 alternative splicing isoforms play opposing roles in cancer., PMID:30456384
Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1., PMID:29864419
PHF5A Epigenetically Inhibits Apoptosis to Promote Breast Cancer Progression., PMID:29700004
Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds., PMID:29656923
PHD-finger domain protein 5A functions as a novel oncoprotein in lung adenocarcinoma., PMID:29566713
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action., PMID:29491137
Splicing modulators act at the branch point adenosine binding pocket defined by the PHF5A-SF3b complex., PMID:28541300
Opposing functions of H2BK120 ubiquitylation and H3K79 methylation in the regulation of pluripotency by the Paf1 complex., PMID:28272987
Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a., PMID:27749823
An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses., PMID:26244496
Screening of cellular proteins that interact with the classical swine fever virus non-structural protein 5A by yeast two-hybrid analysis., PMID:24499791
A spliceosome protein is essential for glioma stem cell viability., PMID:23847366
Genome-wide RNAi screens in human brain tumor isolates reveal a novel viability requirement for PHF5A., PMID:23651857
Evaluating the gene-expression profiles of HeLa cancer cells treated with activated and nonactivated poly(amidoamine) dendrimers, and their DNA complexes., PMID:20394435
For research use only. Not for human or drug use.
