Catalog No.
YHN47401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met22-His181
Predicted molecular weight
20.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q86VP3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Phosphofurin acidic cluster sorting protein 2, PACS-2, PACS1-like protein, PACS2, KIAA0602, PACS1L
Arecoline regulates glycolipid and endoplasmic reticulum metabolisms in adult grass carp (Ctenopharyngodon idella)., PMID:40510831
PACS deficiency disrupts Golgi architecture and causes cytokinesis failures and seizure-like phenotype in Drosophila melanogaster., PMID:39999877
PACS2, PACS1, and VACTERL: A Clinical Overlap., PMID:39911171
Understanding PACS2 syndrome's pathomechanism by studying E209K and E211K mutations., PMID:39738582
PACS2/CPT1A/DHODH signaling promotes cardiomyocyte ferroptosis in diabetic cardiomyopathy., PMID:39633391
Renal denervation improves mitochondrial oxidative stress and cardiac hypertrophy through inactivating SP1/BACH1-PACS2 signaling., PMID:39173402
PACS-1 variant protein is aberrantly localized in Caenorhabditis elegans model of PACS1/PACS2 syndromes., PMID:39031646
PACS-1 variant protein is aberrantly localized in C. elegans model of PACS1/PACS2 syndromes., PMID:38712144
The PACS-2 protein and trafficking motifs in CCHFV Gn and Gc cytoplasmic domains govern CCHFV assembly., PMID:38661085
A missense variant in the PACS2 gene cause Epileptic Encephalopathy and seizures in Saudi family., PMID:38545008
Characteristics of Developmental and Epileptic Encephalopathy Associated with PACS2 p.Glu209Lys Pathogenic Variant-Our Experience and Systematic Review of the Literature., PMID:38540691
Inhibitory protein-protein interactions of the SIRT1 deacetylase are choreographed by post-translational modification., PMID:38533551
Did mitophagy follow the origin of mitochondria?, PMID:38361280
MAPK1 Mediates MAM Disruption and Mitochondrial Dysfunction in Diabetic Kidney Disease via the PACS-2-Dependent Mechanism., PMID:38169625
PACS2 pathogenic variant associated with malformation of cortical development and epilepsy., PMID:38031819
PACS-2 deficiency aggravates tubular injury in diabetic kidney disease by inhibiting ER-phagy., PMID:37794057
Long-Term Outcome of Neonatal Seizure with PACS2 Mutation: Case Series and Literature Review., PMID:37189870
Inhibition of Mitochondrial Fission Alleviates Zearalenone-Induced Mitochondria-Associated Endoplasmic Reticulum Membrane Dysfunction in Piglet Sertoli Cells., PMID:37104191
Mitochondria-associated membrane protein PACS2 maintains right cardiac function in hypobaric hypoxia., PMID:36968068
Zearalenone induces mitochondria-associated endoplasmic reticulum membranes dysfunction in piglet Sertoli cells based on endoplasmic reticulum stress., PMID:36950988
Pyridoxine supplementation in PACS2-related encephalopathy: A case report of possible precision therapy., PMID:36645998
PACS gene family-related neurological diseases: limited genotypes and diverse phenotypes., PMID:36645641
Ferulic acid attenuates high glucose-induced MAM alterations via PACS2/IP3R2/FUNDC1/VDAC1 pathway activating proapoptotic proteins and ameliorates cardiomyopathy in diabetic rats., PMID:36481261
The Phosphofurin Acidic Cluster Sorting Protein 2 (PACS-2) E209K Mutation Responsible for PACS-2 Syndrome Increases Susceptibility to Apoptosis., PMID:36188273
Rare Gene Mutations in Romanian Hypoacusis Patients: Case Series and a Review of the Literature., PMID:36143929
PACS-2 deficiency in tubular cells aggravates lipid-related kidney injury in diabetic kidney disease., PMID:36138342
Molecular Basis of the Schuurs-Hoeijmakers Syndrome: What We Know about the Gene and the PACS-1 Protein and Novel Therapeutic Approaches., PMID:36077045
Knockdown of circ_0002194 protects against oxidized low-density lipoprotein-induced cell damage via the regulation of the miR-637/PACS2 axis in human vascular endothelial cells., PMID:35951762
Icariin inhibits the formation of mitochondria-associated membranes (MAMs) and improves erectile function in rats treated with prostate radiation., PMID:35765205
Low androgen status inhibits erectile function by upregulating the expression of proteins of mitochondria-associated membranes in rat corpus cavernosum., PMID:35466583
Activation of endoplasmic reticulum-mitochondria coupling drives copper-induced autophagy in duck renal tubular epithelial cells., PMID:35339877
Potential role of mitochondria-associated endoplasmic reticulum membrane proteins in diseases., PMID:35314166
PACS2-TRPV1 axis is required for ER-mitochondrial tethering during ER stress and lung fibrosis., PMID:35212819
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy., PMID:35133431
Dysfunctional Endoplasmic Reticulum-Mitochondrion Coupling Is Associated with Endoplasmic Reticulum Stress-Induced Apoptosis and Neurological Deficits in a Rodent Model of Severe Head Injury., PMID:35018820
Vein of Galen aneurysm, dilated cardiomyopathy, and slender habitus in a patient with a recurrent pathogenic variant in PACS2., PMID:34894068
PACS-2 attenuates diabetic kidney disease via the enhancement of mitochondria-associated endoplasmic reticulum membrane formation., PMID:34836936
WDR37 syndrome: identification of a distinct new cluster of disease-associated variants and functional analyses of mutant proteins., PMID:34642815
[Clinical and genetic analysis of PACS2 gene variant in two child patients with developmental and epileptic encephalopathy 66]., PMID:34625934
High-fat diet exacerbated decabromodiphenyl ether-induced hepatocyte apoptosis via intensifying the transfer of Ca2+ from endoplasmic reticulum to mitochondria., PMID:34624399
[Early infantile epileptic encephalopathy caused by PACS2 gene variation: three cases report and literature review]., PMID:34405643
New case with the recurrent c.625G>A pathogenic variant in the PACS2 gene: expanding the phenotype., PMID:34253499
[Genotype and phenotype analysis of neonates with neonatal encephalopathy complicated with perinatal hypoxic event]., PMID:33775046
MAMs Protect Against Ectopic Fat Deposition and Lipid-Related Kidney Damage in DN Patients., PMID:33679616
Coloboma may be a shared feature in a spectrum of disorders caused by mutations in the WDR37-PACS1-PACS2 axis., PMID:33369122
Clinical variations of epileptic syndrome associated with PACS2 variant., PMID:33243487
Chromosome 14 deletions, rings, and epilepsy genes: A riddle wrapped in a mystery inside an enigma., PMID:33205446
PACS-2: A key regulator of mitochondria-associated membranes (MAMs)., PMID:32673704
A further contribution to the delineation of epileptic phenotype in PACS2-related syndrome., PMID:32416568
Mechanistic Connections between Endoplasmic Reticulum (ER) Redox Control and Mitochondrial Metabolism., PMID:31547228
For research use only. Not for human or drug use.
