Catalog No.
YHN47301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly57-Lys370
Predicted molecular weight
38.41 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96L34
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MAP/microtubule affinity-regulating kinase 4, 2.7.11.1, MAP/microtubule affinity-regulating kinase-like 1, MARK4, KIAA1860, MARKL1
Structure-guided discovery of microtubule affinity-regulating kinase 4 inhibitory potential of Harmane: towards therapeutic targeting of Alzheimer's disease., PMID:40504258
The Role of Kinases in Neurodegenerative Diseases: From Pathogenesis to Treatment., PMID:40464332
Impact of Type 1 Diabetes on Testicular Microtubule Dynamics, Sperm Physiology, and Male Reproductive Health in Rat., PMID:40429724
Increased Myocardial MARK4 Expression in Patients with Heart Failure and Sleep-Disordered Breathing., PMID:40332117
Microtubule-Associated Proteins (MAPs) Are Multifunctional Cytoskeletal Proteins in the Testis That Regulate Spermatogenesis., PMID:40301267
Mechanistic insights into the inhibition of microtubule affinity-regulating kinase 4 by Syringic acid: A computational and experimental study., PMID:40216145
Experimental and theoretical studies on structural changes in the microtubule affinity-regulating kinase 4 (MARK4) protein induced by N-hetarenes: a new class of therapeutic candidates for Alzheimer's disease., PMID:40177269
Topological influence of immediate-early genes in brain genetic networks and their link to Alzheimer's disease., PMID:40158459
Improving vulnerable Calbindin1- neurons in the ventral hippocampus rescues tau-induced impairment of episodic memory., PMID:40038800
Tauopathy in AD: Therapeutic Potential of MARK-4., PMID:39931856
4,6-Disubstituted pyrimidine-based microtubule affinity-regulating kinase 4 (MARK4) inhibitors: synthesis, characterization, in-vitro activity and in-silico studies., PMID:39902071
Role of MARK4 in methamphetamine-induced acute kidney injury., PMID:39311784
MARK4 promotes the malignant phenotype of gastric cancer through the MAPK/ERK signaling pathway., PMID:39079384
Exploring the most promising anti - Depressant drug targeting Microtubule Affinity Receptor Kinase 4 involved in Alzheimer's Disease through molecular docking and molecular dynamics simulation., PMID:39052643
Virtual screening and molecular dynamics simulation of natural compounds as potential inhibitors of serine/threonine kinase 16 for anticancer drug discovery., PMID:39031289
Vanillin-Isatin Hybrid-Induced MARK4 Inhibition As a Promising Therapeutic Strategy against Hepatocellular Carcinoma., PMID:38911744
Design, synthesis, molecular docking and anti-proliferative activity of novel phenothiazine containing imidazo[1,2-a]pyridine derivatives against MARK4 protein., PMID:38911173
MARK4 aggravates cardiac dysfunction in mice with STZ-induced diabetic cardiomyopathy by regulating ACSL4-mediated myocardial lipid metabolism., PMID:38839927
Ropinirole reverses the effects of neuroinflammation, and cellular demise by downregulating the MARK4-NFκβ signaling system in Alzheimer's disease., PMID:38759860
Mark4 ablation attenuates pathological phenotypes in a mouse model of tauopathy., PMID:38712317
Immediate-Early Genes as Influencers in Genetic Networks and their Role in Alzheimer's Disease., PMID:38585978
Qingzhuan dark tea Theabrownin alleviates hippocampal injury in HFD-induced obese mice through the MARK4/NLRP3 pathway., PMID:38455533
Harnessing memantine in Alzheimer's disease therapy through inhibition of microtubule affinity-regulating kinase: Mechanistic insights., PMID:38342269
Microtubule-affinity regulating kinase family members distinctively affect tau phosphorylation and promote its toxicity in a Drosophila model., PMID:38329182
Interaction of Sp1 and Setd8 promotes vascular smooth muscle cells apoptosis by activating Mark4 in vascular calcification., PMID:38301049
Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke., PMID:38181310
Enhancing productivity of Chinese hamster ovary (CHO) cells: synergistic strategies combining low-temperature culture and mTORC1 signaling engineering., PMID:38076428
Gain-of-function MARK4 variant associates with pediatric neurodevelopmental disorder and dysmorphism., PMID:38041405
A cell-penetrating peptide derived from SARS-CoV-2 protein Orf9b allosterically inhibits MARK4 activity and mitigates tau toxicity., PMID:37884211
Preparation of nanoformulation of 5-fluorouracil to improve anticancer efficacy: integrated spectroscopic, docking, and MD simulation approaches., PMID:37850451
Mechanistic insights into MARK4 inhibition by galantamine toward therapeutic targeting of Alzheimer's disease., PMID:37795023
Therapeutic targeting of microtubule affinity-regulating kinase 4 in cancer and neurodegenerative diseases., PMID:37661636
A Novel Interaction between MFN2/Marf and MARK4/PAR-1 Is Implicated in Synaptic Defects and Mitochondrial Dysfunction., PMID:37550059
Exploratory genome-wide analyses of cortical inhibition, facilitation, and plasticity in late-life depression., PMID:37391420
Investigating MARK4 inhibitory potential of Bacopaside II: Targeting Alzheimer's disease., PMID:37315665
In silico investigation and potential therapeutic approaches of isoquinoline alkaloids for neurodegenerative diseases: computer-aided drug design perspective., PMID:37184133
Inhibition of microtubule affinity regulating kinase 4 by an acetylcholinesterase inhibitor, Huperzine A: Computational and experimental approaches., PMID:36870649
Profiling the male germline genome to unravel its reproductive potential., PMID:36379263
Role of lisinopril in the therapeutic management of cardiovascular disease by targeting microtubule affinity regulating kinase 4: molecular docking and molecular dynamics simulation approaches., PMID:36376029
Targeting inhibition of microtubule affinity regulating kinase 4 by Harmaline: Strategy to combat Alzheimer's disease., PMID:36257368
MARK2 and MARK4 Regulate Sertoli Cell BTB Dynamics Through Microtubule and Actin Cytoskeletons., PMID:35971301
Microtubule-affinity regulating kinase 4: A potential drug target for cancer therapy., PMID:35961526
Multitargeting the Action of 5-HT6 Serotonin Receptor Ligands by Additional Modulation of Kinases in the Search for a New Therapy for Alzheimer's Disease: Can It Work from a Molecular Point of View?, PMID:35955902
A Network-Guided Approach to Discover Phytochemical-Based Anticancer Therapy: Targeting MARK4 for Hepatocellular Carcinoma., PMID:35936719
Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches., PMID:35889524
Inhibition of MARK4 by serotonin as an attractive therapeutic approach to combat Alzheimer's disease and neuroinflammation., PMID:35814926
Sleep and Late-Onset Alzheimer's Disease: Shared Genetic Risk Factors, Drug Targets, Molecular Mechanisms, and Causal Effects., PMID:35656316
KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling., PMID:35449131
MARK2/4 promotes Warburg effect and cell growth in non-small cell lung carcinoma through the AMPKα1/mTOR/HIF-1α signaling pathway., PMID:35192892
Microtubule Affinity-Regulating Kinase 4 Promotes Oxidative Stress and Mitochondrial Dysfunction by Activating NF-κB and Inhibiting AMPK Pathways in Porcine Placental Trophoblasts., PMID:35052845
For research use only. Not for human or drug use.
