Catalog No.
YHN47101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys276
Predicted molecular weight
31.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96C36
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pyrroline-5-carboxylate reductase 2, P5C reductase 2, P5CR 2, 1.5.1.2, PYCR2
Metabolomic liquid biopsy dynamics predict early-stage HCC and actionable candidates of human hepatocarcinogenesis., PMID:40290517
Activation of mTOR/HK2 signaling mitigates effects of PYCR2 depletion in colorectal cells., PMID:39808866
Metabolism-related proteins as biomarkers for predicting prognosis in polycystic ovary syndrome., PMID:39702179
Comprehensive profiling of migratory primordial germ cells reveals niche-specific differences in non-canonical Wnt and Nodal-Lefty signaling in anterior vs posterior migrants., PMID:39257761
Exploration of influenza A virus PA protein-associated cellular proteins discloses its impact on mitochondrial function., PMID:38719025
Exploring metabolic alterations in PYCR2 deficiency: Unveiling pathways and clinical presentations of hypomyelinating leukodystrophy 10., PMID:38709052
Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer., PMID:38354856
Proline restores mitochondrial function and reverses aging hallmarks in senescent cells., PMID:38354087
PYCR2, induced by c-Myc, promotes the invasiveness and metastasis of breast cancer by activating AKT signalling pathway., PMID:38101533
The pan-cancer landscape of glutamate and glutamine metabolism: A comprehensive bioinformatic analysis across 32 solid cancer types., PMID:38065270
PYCR2 promotes growth and aerobic glycolysis in human liver cancer by regulating the AKT signaling pathway., PMID:37708598
Genetic etiology of progressive pediatric neurological disorders., PMID:37563452
Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Carcinogenesis by Modulating Microtubule-Associated Serine/Threonine Kinase-like/Wnt/β-Catenin Signaling., PMID:37508547
LncRNA MALAT1 regulates growth of carcinoma of the lung through modulating miR-338-3p/PYCR2 axis., PMID:37329534
Corrigendum to "African swine fever virus protein E199L promotes cell autophagy through the interaction of PYCR2" [Virol Sin 36 (2021) 196-206]., PMID:37286393
Pyrroline-5-carboxylate reductase 2 (PYCR2) deficiency causes hereditary spastic paraplaegia in late childhood., PMID:37141741
PYCR in Kidney Renal Papillary Cell Carcinoma: Expression, Prognosis, Gene Regulation Network, and Regulation Targets., PMID:36624948
Hypomyelinating Leukodystrophy 10 (HLD10)-Associated Mutations of PYCR2 Form Large Size Mitochondria, Inhibiting Oligodendroglial Cell Morphological Differentiation., PMID:36548190
Targeting PYCR2 inhibits intraperitoneal metastatic tumors of mouse colorectal cancer in a proline-independent approach., PMID:36308281
Differential Degradation of TRA2A and PYCR2 Mediated by Ubiquitin E3 Ligase E4B., PMID:35669517
Pyrroline-5-Carboxylate Reductase 1: a novel target for sensitizing multiple myeloma cells to bortezomib by inhibition of PRAS40-mediated protein synthesis., PMID:35105345
Pyrroline-5-Carboxylate Reductase-2 Promotes Colorectal Cancer Progression via Activating PI3K/AKT/mTOR Pathway., PMID:34512817
The upregulation of PYCR2 is associated with aggressive colon cancer progression and a poor prognosis., PMID:34332325
Expanding the genotypic spectrum of PYCR2 and a common ancestry in Thai patients with hypomyelinating leukodystrophy 10., PMID:34037307
African Swine Fever Virus Protein E199L Promotes Cell Autophagy through the Interaction of PYCR2., PMID:33830435
Disease variants of human Δ1-pyrroline-5-carboxylate reductase 2 (PYCR2)., PMID:33771508
Spastic paraplegia as the only symptom in two adult-onset patients carrying a novel pathogenic variant in PYCR2., PMID:32920934
PYRC2-Related Hypomyelinating Leukodystrophy: More to This Than Meets the Eye., PMID:32645307
Identification of potential cervical cancer serum biomarkers in Thai patients., PMID:32391095
Loss of PYCR2 Causes Neurodegeneration by Increasing Cerebral Glycine Levels via SHMT2., PMID:32330411
Pyrroline-5-Carboxylate Reductase 2 Deficiency: A New Case and Review of the Literature., PMID:31918782
Integrated Proteogenomic Characterization of HBV-Related Hepatocellular Carcinoma., PMID:31585088
Kindlin-2 links mechano-environment to proline synthesis and tumor growth., PMID:30783087
Spatially resolved metabolomics to discover tumor-associated metabolic alterations., PMID:30559182
Homozygous variants in pyrroline-5-carboxylate reductase 2 (PYCR2) in patients with progressive microcephaly and hypomyelinating leukodystrophy., PMID:27860360
PYCR2 Mutations cause a lethal syndrome of microcephaly and failure to thrive., PMID:27130255
PYCR1 and PYCR2 Interact and Collaborate with RRM2B to Protect Cells from Overt Oxidative Stress., PMID:26733354
Downregulation of pyrroline-5-carboxylate reductase-2 induces the autophagy of melanoma cells via AMPK/mTOR pathway., PMID:26634742
Mutations in PYCR2, Encoding Pyrroline-5-Carboxylate Reductase 2, Cause Microcephaly and Hypomyelination., PMID:25865492
Functional specialization in proline biosynthesis of melanoma., PMID:23024808
For research use only. Not for human or drug use.
