Catalog No.
YHN46701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr47-Glu722
Predicted molecular weight
78.21 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8IYB8
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATP-dependent RNA helicase SUPV3L1, mitochondrial, 3.6.4.13, Suppressor of var1 3-like protein 1, SUV3-like protein 1, SUPV3L1, SUV3
Spatial analysis of mitochondrial gene expression reveals dynamic translation hubs and remodeling in stress., PMID:40249810
Fast Degradation of MecciRNAs by SUPV3L1/ELAC2 Provides a Novel Opportunity to Tackle Heart Failure With Exogenous MecciRNA., PMID:39973625
A New Case of Mitochondrial RNA Helicase SUPV3L1-Associated Neurodegenerative Disease: Ataxia, Spasticity, Optic Atrophy, and Skin Hypopigmentation (ASOASH)., PMID:39596606
[SUV3 knockdown inhibits proliferation, migration, and invasion of hepatocellular carcinoma cells and induces PD-L1 expression]., PMID:39267568
RNA degradation in human mitochondria: the journey is not finished., PMID:38779774
The diagnostic yield, candidate genes, and pitfalls for a genetic study of intellectual disability in 118 middle eastern families., PMID:36344539
Leber's hereditary optic neuropathy-associated ND6 14484T > C mutation caused pleiotropic effects on the complex I, RNA homeostasis, apoptosis and mitophagy., PMID:35567411
Dimeric assembly of human Suv3 helicase promotes its RNA unwinding function in mitochondrial RNA degradosome for RNA decay., PMID:35481630
Mitochondrial RNA processing defect caused by a SUPV3L1 mutation in two siblings with a novel neurodegenerative syndrome., PMID:35023579
Translatomic profiling reveals novel self-restricting virus-host interactions during HBV infection., PMID:33621634
The plasma peptides of sepsis., PMID:32636717
Identification of immune cells and mRNA associated with prognosis of gastric cancer., PMID:32164594
Integrating transcriptome-wide study and mRNA expression profiles yields novel insights into the biological mechanism of chondropathies., PMID:31455417
Controlling the mitochondrial antisense - role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance., PMID:30525095
Mitochondrial double-stranded RNA triggers antiviral signalling in humans., PMID:30046113
Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria., PMID:29967381
Polyadenylation and degradation of structurally abnormal mitochondrial tRNAs in human cells., PMID:29518244
Human SUV3 helicase regulates growth rate of the HeLa cells and can localize in the nucleoli., PMID:28291845
Regulation of the human Suv3 helicase on DNA by inorganic cofactors., PMID:25446650
Helicase SUV3, polynucleotide phosphorylase, and mitochondrial polyadenylation polymerase form a transient complex to modulate mitochondrial mRNA polyadenylated tail lengths in response to energetic changes., PMID:24770417
Yeast and human mitochondrial helicases., PMID:23454114
Human mitochondrial RNA decay mediated by PNPase-hSuv3 complex takes place in distinct foci., PMID:23221631
LRPPRC/SLIRP suppresses PNPase-mediated mRNA decay and promotes polyadenylation in human mitochondria., PMID:22661577
Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan., PMID:22562243
RNA degradation in yeast and human mitochondria., PMID:22178375
Human Suv3 protein reveals unique features among SF2 helicases., PMID:22101826
The human Suv3 helicase interacts with replication protein A and flap endonuclease 1 in the nucleus., PMID:21846330
RNA turnover in human mitochondria: more questions than answers?, PMID:20117077
[Final doctorate competition 2009. Study of hSuv3p human helicase function]., PMID:21473039
Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse., PMID:19937380
Human mitochondrial RNA turnover caught in flagranti: involvement of hSuv3p helicase in RNA surveillance., PMID:19864255
Human mitochondrial SUV3 and polynucleotide phosphorylase form a 330-kDa heteropentamer to cooperatively degrade double-stranded RNA with a 3'-to-5' directionality., PMID:19509288
Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death., PMID:19145458
Role of SUV3 helicase in maintaining mitochondrial homeostasis in human cells., PMID:18678873
Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality., PMID:17961633
Down-regulation of human RNA/DNA helicase SUV3 induces apoptosis by a caspase- and AIF-dependent pathway., PMID:17352692
Human ATP-dependent RNA/DNA helicase hSuv3p interacts with the cofactor of survivin HBXIP., PMID:16176273
The 5' region of the human hSUV3 gene encoding mitochondrial DNA and RNA helicase: promoter characterization and alternative pre-mRNA splicing., PMID:15919122
Purified human SUV3p exhibits multiple-substrate unwinding activity upon conformational change., PMID:15096047
Localisation of the human hSuv3p helicase in the mitochondrial matrix and its preferential unwinding of dsDNA., PMID:12466530
A human putative Suv3-like RNA helicase is conserved between Rhodobacter and all eukaryotes., PMID:10453991
Assignment1 of SUPV3L1 to human chromosome band 10q22.1 by in situ hybridization., PMID:9925937
For research use only. Not for human or drug use.
