Catalog No.
YHK97501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln22-Asn505
Predicted molecular weight
56.76 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96RQ9
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
L-amino-acid oxidase, LAAO, LAO, 1.4.3.2, 1.4.3.25, Interleukin-4-induced protein 1, IL4-induced protein 1, hIL4I1, Protein Fig-1, hFIG1, IL4I1, FIG1, UNQ636/PRO1265
Identification of potential IL4I1 inhibitors through structure-based virtual screening and molecular dynamics simulations., PMID:40411435
IL4I1 knockdown inhibits the epithelial-mesenchymal transition process in glioma via downregulation of the JAK2/STAT3 signaling pathway., PMID:40353627
Immunohistochemical Profiling of IDO1 and IL4I1 in Head and Neck Squamous Cell Carcinoma: Interplay for Metabolic Reprogramming?, PMID:40332319
Differential Effects of IL4I1 Protein on Lymphocytes From Healthy and Multiple Sclerosis Patients., PMID:40102177
Monocyte-lineage tumor infiltration predicts immunoradiotherapy response in advanced pretreated soft-tissue sarcoma: phase 2 trial results., PMID:40097400
Spatial Metabolomics and Transcriptomics Reveal Metabolic Reprogramming and Cellular Interactions in Nasopharyngeal Carcinoma with High PD-1 Expression and Therapeutic Response., PMID:40083932
Macrophage-mediated activation of the IL4I1/AhR axis is a key player in allergic rhinitis., PMID:40080924
Regulating macrophage phenotypes with IL4I1-mimetic nanoparticles in IDD treatment., PMID:40050923
Genomically Selected Genes Associated with a High Rate of Egg Production in Puan Panjiang Black-Bone Chickens., PMID:39943134
Knockout IL4I1 affects macrophages to improve poor efficacy of CD19 CAR-T combined with PD-1 inhibitor in relapsed/refractory diffuse large B-cell lymphoma., PMID:39844281
Renal remodeling by CXCL10-CXCR3 axis-recruited mesenchymal stem cells and subsequent IL4I1 secretion in lupus nephritis., PMID:39557841
IL-4-Induced Gene 1: A Potential Player in Myocardial Infarction., PMID:39355609
Integrated metabolic-transcriptomic network identifies immunometabolic modulations in human macrophages., PMID:39276347
Targeting amino acid-metabolizing enzymes for cancer immunotherapy., PMID:39211039
Proteomics and Metabolic Characteristics of Boar Seminal Plasma Extracellular Vesicles Reveal Biomarker Candidates Related to Sperm Motility., PMID:39067049
Distinct functions of wild-type and R273H mutant Δ133p53α differentially regulate glioblastoma aggressiveness and therapy-induced senescence., PMID:38937431
Obesity enhances the response to neoadjuvant anti-PD1 therapy in oral tongue squamous cell carcinoma., PMID:38923758
Central memory CD4+ T cells play a protective role against immune checkpoint inhibitor-associated myocarditis., PMID:38850163
Male infertility and perfluoroalkyl and poly-fluoroalkyl substances: evidence for alterations in phosphorylation of proteins and fertility-related functional attributes in bull spermatozoa†., PMID:38847481
Pan-cancer analysis of prognostic and immunological role of IL4I1 in human tumors: a bulk omics research and single cell sequencing validation., PMID:38691253
New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis., PMID:38605962
Upregulation of IL4-induced gene 1 enzyme by B2 cells during melanoma progression impairs their antitumor properties., PMID:38400692
Interleukin-4 induced 1-mediated resistance to an immune checkpoint inhibitor through suppression of CD8+ T cell infiltration in melanoma., PMID:38258342
IL4I1 in M2-like macrophage promotes glioma progression and is a promising target for immunotherapy., PMID:38250074
Transcriptomic and Translatomic Analyses Reveal Insights into the Signaling Pathways of the Innate Immune Response in the Spleens of SPF Chickens Infected with Avian Reovirus., PMID:38140587
Extracellular vesicles derived from nasopharyngeal carcinoma induce the emergence of mature regulatory dendritic cells using a galectin-9 dependent mechanism., PMID:38117000
Tryptophan metabolism enzymes are potential targets in ovarian clear cell carcinoma., PMID:38062922
Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy., PMID:37963637
The complex biology of aryl hydrocarbon receptor activation in cancer and beyond., PMID:37696456
Mechanical confinement promotes heat resistance of hepatocellular carcinoma via SP1/IL4I1/AHR axis., PMID:37478857
High expression of IL4I1 is correlated with poor prognosis and immune infiltration in thyroid cancer., PMID:37434155
Expression Pattern and Prognostic Analysis of Branched-Chain Amino Acid Catabolism-Related Genes in Non-Small Cell Lung Cancer., PMID:37395022
Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes., PMID:37344101
Fatty acids metabolism affects the therapeutic effect of anti-PD-1/PD-L1 in tumor immune microenvironment in clear cell renal cell carcinoma., PMID:37221577
IL4i1 and IDO1: Oxidases that control a tryptophan metabolic nexus in cancer., PMID:37196768
Expression of Tryptophan Metabolism Enzymes in Patients with Diffuse Large B-cell Lymphoma and NK/T-cell Lymphoma., PMID:37148546
RNA-Seq Profiling between Commercial and Indigenous Iranian Chickens Highlights Differences in Innate Immune Gene Expression., PMID:37107551
Novel Potential Mechanisms of Regulatory B Cell-Mediated Immunosuppression., PMID:37068869
CCL17 acts as an antitumor chemokine in micromilieu-driven immune skewing., PMID:37001380
Knockdown of IL4I1 Improved High Glucose-evoked Insulin Resistance in HepG2 Cells by Alleviating Inflammation and Lipotoxicity Through AHR Activation., PMID:36913096
Human Chorionic Gonadotropin-Stimulated Interleukin-4-Induced-1 (IL4I1) Promotes Human Decidualization via Aryl Hydrocarbon Receptor., PMID:36834576
Inhibitors of Interleukin 4 Induced Protein 1 (IL4I1) as Potential Treatment for Cancer., PMID:36793430
Cluster of resistance-inducing genes in MCF-7 cells by estrogen, insulin, methotrexate and tamoxifen extracted via NMF., PMID:36738509
Metabolomics and Lipidomics Screening Reveal Reprogrammed Signaling Pathways toward Cancer Development in Non-Alcoholic Steatohepatitis., PMID:36613653
JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced acute lung injury via H3K27 and H3K4 demethylation., PMID:36537648
Identification of fatty acid metabolism-related molecular subtype biomarkers and their correlation with immune checkpoints in cutaneous melanoma., PMID:36466837
Expression profile of immunoregulatory factors in canine tumors., PMID:36327941
Tryptophan metabolism and disposition in cancer biology and immunotherapy., PMID:36286592
IL4I1 binds to TMPRSS13 and competes with SARS-CoV-2 spike., PMID:36131918
IL4I1 enhances PD-L1 expression through JAK/STAT signaling pathway in lung adenocarcinoma., PMID:36056935
For research use only. Not for human or drug use.
