Catalog No.
YHH45001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu654-Glu946
Predicted molecular weight
35.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q27J81
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Inverted formin-2, HBEBP2-binding protein C, INF2, C14orf151, C14orf173
Integrated bioinformatic analysis of immune infiltration and disulfidptosis related gene subgroups in type A aortic dissection., PMID:40258895
Cisplatin-induced disruption of mitochondrial divisome leads to enhanced cisplatin resistance in cholangiocarcinoma., PMID:40189106
Formin INF2 supplementation alleviates cytoskeleton-based mitochondria defects for oocyte quality under obesity., PMID:40180021
The activation of INF2 by Piezo1/Ca2+ is required for mesenchymal-to-amoeboid transition in confined environments., PMID:40120583
Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation., PMID:39986274
Genetic landscape of Charcot-Marie-Tooth disease in Vietnam: A prospective multicenter study., PMID:39973457
Cyclase-associated protein: an actin regulator with multiple neuronal functions., PMID:39934054
Mitochondria- and ER-associated actin are required for mitochondrial fusion., PMID:39774009
Dynll1-PI31 Interaction Enhances Proteolysis Through the Proteasome, Representing a Novel Therapeutic Target for INF2-Related FSGS., PMID:39621430
Co-occurrence of Charcot-Marie-Tooth disease type 1 and glomerulosclerosis in a patient with a de novo INF2 variant., PMID:39609740
Regulation of formin INF2 and its alteration in INF2-linked inherited disorders., PMID:39586895
INF2 mutations cause kidney disease through a gain-of-function mechanism., PMID:39536114
Altered Endoplasmic Reticulum Integrity and Organelle Interactions in Living Cells Expressing INF2 Variants., PMID:39337270
SUN2 mediates calcium-triggered nuclear actin polymerization to cluster active RNA polymerase II., PMID:39317734
INF2-mediated actin polymerization at ER-organelle contacts regulates organelle size and movement., PMID:39184068
Cyclase-associated protein (CAP) inhibits inverted formin 2 (INF2) to induce dendritic spine maturation., PMID:39154297
Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study., PMID:38972501
INF2 formin variants linked to human inherited kidney disease reprogram the transcriptome, causing mitotic chaos and cell death., PMID:38916773
Mechanisms of actin filament severing and elongation by formins., PMID:38843827
Prevalence of kidney health genetic variants in adults with sickle cell nephropathy., PMID:38735682
The DNA-dependent protein kinase catalytic subunit promotes sepsis-induced cardiac dysfunction through disrupting INF-2-dependent mitochondrial dynamics., PMID:38464839
Establishing a human-induced pluripotent stem cell line (SMUSHi003-A) from a patient with Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis., PMID:38412658
Functional genetic variants of the disulfidptosis-related INF2 gene predict survival of hepatitis B virus-related hepatocellular carcinoma., PMID:38270181
Phosphorylation of INF2 by AMPK promotes mitochondrial fission and oncogenic function in endometrial cancer., PMID:38233384
Drebrin Protects Assembled Actin from INF2-FFC-mediated Severing and Stabilizes Cell Protrusions., PMID:38158176
Characterization of Expression and Function of the Formins FHOD1, INF2, and DAAM1 in HER2-Positive Breast Cancer., PMID:37985384
Activated Drp1 Initiates the Formation of Endoplasmic Reticulum-Mitochondrial Contacts via Shrm4-Mediated Actin Bundling., PMID:37909346
Pan-cancer genetic analysis of disulfidptosis-related gene set., PMID:37879141
Phenotype-driven reanalysis reveals five novel pathogenic variants in 40 exome-negative families with Charcot-Marie-Tooth Disease., PMID:37776383
INF2 and ROBO2 gene mutation in an Indian family with end stage renal failure and follow-up of renal transplantation., PMID:37772439
Concurrent Cobalamin C and Plasminogen Deficiencies in a Patient with Chronic Thrombotic Microangiopathy., PMID:37611544
Ocular manifestations of the genetic causes of focal and segmental glomerulosclerosis., PMID:37578539
Characterization of cytoskeletal and structural effects of INF2 variants causing glomerulopathy and neuropathy., PMID:37491439
Mitochondria- and ER-associated actin are required for mitochondrial fusion., PMID:37398222
FBXO7, a tumor suppressor in endometrial carcinoma, suppresses INF2-associated mitochondrial division., PMID:37344480
The multiple links between actin and mitochondria., PMID:37277471
Genetic features and kidney morphological changes in women with X-linked Alport syndrome., PMID:37225412
Myo19 tethers mitochondria to endoplasmic reticulum-associated actin to promote mitochondrial fission., PMID:36744380
Ethanol-induced ceramide production causes neuronal apoptosis by increasing MCL-1S-mediated ER-mitochondria contacts., PMID:36689912
INF2 mutations in patients with a broad phenotypic spectrum of Charcot-Marie-Tooth disease and focal segmental glomerulosclerosis., PMID:36637069
Structure and function of the N-terminal extension of the formin INF2., PMID:36306014
INF2-mediated actin filament reorganization confers intrinsic resilience to neuronal ischemic injury., PMID:36229429
Clinical, Pathological, and Genetic Characteristics in Patients with Focal Segmental Glomerulosclerosis., PMID:36176665
Causal and putative pathogenic mutations identified in 39% of children with primary steroid-resistant nephrotic syndrome in South Africa., PMID:35920919
Quantitative proteomic landscapes of primary and recurrent glioblastoma reveal a protumorigeneic role for FBXO2-dependent glioma-microenvironment interactions., PMID:35802605
Myosin II proteins are required for organization of calcium-induced actin networks upstream of mitochondrial division., PMID:35427150
Parallel actin monomers in the 8S complex of actin-INF2., PMID:35343388
Clinical, pathological, and genetic characteristics of cases with asymptomatic proteinuria not manifesting nephrotic syndrome at onset: a single-center retrospective study., PMID:35113255
The Frequency of Genetic Mutations in Pediatric Patients Diagnosed with Nephrotic Syndrome: A Single-Center Retrospective Study in Saudi Arabia., PMID:35102923
A Closer Look at Dexamethasone and the SARS-CoV-2-Induced Cytokine Storm: In Silico Insights of the First Life-Saving COVID-19 Drug., PMID:34943719
For research use only. Not for human or drug use.
