Catalog No.
YHH34302
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp55-Val342
Predicted molecular weight
35.61 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16665
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Hypoxia-inducible factor 1-alpha, HIF-1-alpha, HIF1-alpha, ARNT-interacting protein, Basic-helix-loop-helix-PAS protein MOP1, Class E basic helix-loop-helix protein 78, bHLHe78, Member of PAS protein 1, PAS domain-containing protein 8, HIF1A, BHLHE78, MOP1, PASD8
Pharmacological HIF-PH Inhibition Suppresses Myoblast Differentiation Through Continued HIF-1α Stabilization., PMID:40508217
ADAM32 Oncogene in Hepatoblastoma Is Regulated by IGF2BP2., PMID:40507253
Injectable Methylcellulose/Hyaluronic Acid/Collagen Hydrogel Loaded With Adipose-Derived Stem Cells Alleviates Skin Photoaging via Inhibition of HIF-1α: An in Vitro and in Vivo Study., PMID:40504120
Dynamic VOC fingerprinting and mechanistic exploration of medicinal edible fungus Inonotus hispidus: A combination of HS-GC-IMS/MS multivariate analysis and network-based pharmacology., PMID:40499502
Purinergic Receptor P2Y2 Activity Prevents DNA Damage in CCl4-Induced Hepatic Fibrosis., PMID:40495470
MicroRNA-6084 orchestrates angiogenesis and liver metastasis in colorectal cancer via extracellular vesicles., PMID:40493409
HIF-1α Promotes Inflammatory Responses in Aspergillus Fumigatus Keratitis by Activating Pyroptosis Through Caspase-8/GSDMD Pathway., PMID:40492985
Inhibitors of p53 Apoptosis-Stimulating Protein Mitigate Acute Kidney Injury by Modulating the HIF-1α/SLC7A11 Pathway to Suppress Ferroptosis., PMID:40492946
Identification of autophagy-related genes in intestinal ischemia-reperfusion injury and their role in immune infiltration., PMID:40491449
Sex- and subregion-specific vulnerability of the hippocampus and amygdala to intermittent hypoxia in relation to learning/memory function and anxiety tendencies of infant rats., PMID:40490588
Unveiling pharmacological targets of Rihimaside C for radiation-induced lung injury: An in silico and experimental integrated approach., PMID:40486275
Natural Flavonoids as Anticancer Agents: Targeting the HIF-1α Signaling Pathway., PMID:40484654
Comparative analysis of respiratory metabolism, blood physiology, antioxidant capacity, and hypoxia-related gene expression in Snowy White chickens raised at high and low altitudes., PMID:40483906
Senescence caused by telomerase inactivation in myeloid, mesenchymal, and endothelial cells has distinct effects on cancer progression., PMID:40482194
Unraveling anti-atherosclerosis mechanism of anthocyanins from Xinjiang wild cherry plum (Prunus divaricata Ledeb) via network pharmacology and molecular docking., PMID:40478326
Oxygen-Generating Biomimetic Nano-Herb System for Synergistic Therapy & Pain Relief in Triple-Negative Breast Cancer via HIF-1α/VEGF Pathway., PMID:40470112
Computational and Molecular Profiling of the Anticancer Properties of Thuja occidentalis L. From Southern Punjab., PMID:40468803
Hypoxia-inducible factor-1 alpha and nuclear factor erythroid 2-related factor 2 as biomarkers of renal scarring in children with congenital anomalies of the kidney and urinary tract: a prospective case-control study., PMID:40468229
Chemoproteomics reveals Ailanthone directly binds to PKM2 to inhibit the progression of Hepatocellular carcinoma., PMID:40466508
Srebf and Runx3 regulate hepatic HMG-CoA reductase and intracellular cholesterol under hypoxia., PMID:40464811
A novel oncogene, leucine-rich repeat protein 1, mediates hypoxia-induced hepatocellular carcinoma progression., PMID:40459634
Short-Term DMOG treatment rejuvenates senescent mesenchymal stem cells by enhancing mitochondrial function and mitophagy through the HIF-1α/BNIP3 pathway., PMID:40457488
Ubiquitin C-terminal hydrolase L1 promoted pro-angiogenic capacity of periodontal ligament stem cells via HIF-1α/YAP signaling in periodontitis., PMID:40457476
The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response., PMID:40455982
Enhancement of endometrial receptivity by Bushen Zhuyun Decoction via cryptotanshinone-mediated TRIM28 induction and HIF-1α suppression., PMID:40449692
FTVI promotes osteogenic differentiation of bone marrow mesenchymal stem cells through LncRNA HIF1A-AS2., PMID:40448168
Computational investigation and experimental validation of the molecular mechanism of Solanecio mannii aqueous roots extract against cervical cancer., PMID:40446016
Differences in the Blood Levels of HIF-1α and VNN1 and Expression of HIF1A and NFKB1 in Leukocytes in Cardiological Patients with Risk of Postoperative Complications., PMID:40445541
Reduced iron bioavailability drives acute high‑altitude lung injury through HIF1α activation and mitophagy., PMID:40444479
Analysis of Specific MicroRNAs Expressed after Intake of Cobalt and Xenon Preparations for Anti-Doping Control., PMID:40442471
RNF20 links the DNA damage response and metabolic rewiring in lung cancer through HIF1α., PMID:40436847
Inactivation of the PHD3-FOXO3 axis blunts the type I interferon response in microglia and ameliorates Alzheimer's disease progression., PMID:40435260
Correlation between changes in haemorheology and the HIF-1/EPO pathway in children with Mycoplasma pneumoniae pneumonia., PMID:40434092
Role of Digoxin in Preventing Cigarette Smoke-Induced COPD via HIF-1α Inhibition in a Mouse Model., PMID:40433398
A Study on the Levels of Selected Proangiogenic Proteins in Human Tissues and Plasma in Relation to Brain Glioma., PMID:40429943
Characterization of Extrachromosomal Circular DNA in Primary and Cisplatin-Resistant High-Grade Serous Ovarian Cancer., PMID:40428339
HIF1A Regulates Rhbg Expression to Enhance Ammonia Excretion in Amur Ide (Leuciscus waleckii) Under Extreme Alkaline Conditions., PMID:40427687
CA9-Positive Keloid Fibroblasts: Modulator of Local Inflammation Induced by the Hypoxic and Glycolysis-enhanced Microenvironment., PMID:40425327
ASAP1 protein macromolecule promotes the growth and development of gastric cancer cells and the remodeling of F-actin cytoskeleton: Expression of VEGF and HIF-1 α proteins., PMID:40424906
TAMs-derived SPP1, regulated by HIF-1α/STAT3 signaling pathway, influences colorectal cancer malignant progression by activation of EMT via integrin αvβ3., PMID:40424660
Rotenoids from the Roots of Vicia faba L. (Fabaceae): Structural Characterization, Cytotoxic Effects, and Molecular Docking., PMID:40418826
Mechanistic study of the association between microRNA-126 and hypertension in obstructive sleep apnea-hypopnea syndrome., PMID:40418154
Mechanism Analysis of Zuogui and Yougui Pills on Diabetic Nephropathy Through Transcriptional Regulatory Networks of HIF1A and PPARA., PMID:40417738
[Curcumin inhibits lipid metabolism in non-small cell lung cancer by downregulating the HIF-1α pathway]., PMID:40415436
[Eye acupuncture improves neural function in rats with cerebral ischemia-reperfusion injury by promoting angiogenesis via upregulating METTL3-mediated m6A methylation]., PMID:40415423
Hypoxia-inducible factor-1α promotes tubulointerstitial fibrosis via the upregulation of Muc4., PMID:40415252
Microplastic exposure induces preeclampsia-like symptoms via HIF-1α/TFRC-mediated ferroptosis in placental trophoblast cells., PMID:40414414
Unraveling the metabolic gene expression and energetic patterns of the seasonally acclimatized gilthead seabream., PMID:40411699
Exosomal PD-L1 derived from hypoxia nasopharyngeal carcinoma cell exacerbates CD8+ T cell suppression by promoting PD-L1 upregulation in macrophages., PMID:40411570
Carbonic anhydrase IX downregulation linked to disruption of HIF-1, NFκB and STAT3 pathways as a new mechanism of ibuprofen anti-cancer effect., PMID:40408503
For research use only. Not for human or drug use.
