Catalog No.
YHG91301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gly132
Predicted molecular weight
17.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14847
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LIM and SH3 domain protein 1, LASP-1, Metastatic lymph node gene 50 protein, MLN 50, LASP1, MLN50
DAB2 binds to LASP1 to participate in migration and invasion of non-small cell lung cancer through TGF-β/Smad pathway., PMID:40436729
NAT10 promotes the progression of clear cell renal cell carcinoma by regulating ac4C acetylation of NFE2L3 and activating AKT/GSK3β signaling pathway., PMID:40169553
Unique Presentation of Autoinflammatory Disease-like Symptoms and Development of Leukemic Cell Lysis Pneumopathy in Childhood KMT2A::LASP1 -positive Acute Monocytic Leukemia., PMID:39961013
LASP1 inhibits the formation of NETs and alleviates acute pancreatitis by stabilizing F-actin polymerization in neutrophils., PMID:39708397
Insights into the regulation of mRNA translation by scaffolding proteins., PMID:39641595
CircTIAM1 overexpression promotes the progression of papillary thyroid cancer by regulating the miR-338-3p/LASP1 axis., PMID:39449799
LASP1 in the nucleus accumbens modulates methamphetamine-induced conditioned place preference in mice., PMID:39419179
Flavopereirine Suppresses the Progression of Human Oral Cancer by Inhibiting the JAK-STAT Signaling Pathway via Targeting LASP1 [Letter]., PMID:39228429
miR-143-3p modulates depressive-like behaviors via Lasp1 in the mouse ventral hippocampus., PMID:39098885
E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer., PMID:38789663
lncRNA PAARH impacts liver cancer cell proliferation by engaging miR‑6512‑3p to target LASP1., PMID:38774456
Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway., PMID:38713618
[Corrigendum] Long non‑coding RNA H19 regulates LASP1 expression in osteosarcoma by competitively binding to miR‑29a‑3p., PMID:38639176
Inhibition of GLUD1 mediated by LASP1 and SYVN1 contributes to hepatitis B virus X protein-induced hepatocarcinogenesis., PMID:38587834
Focal adhesion protein Lasp1 links the Arp2/3 complex to adherens junctions and promotes motility of arthritic fibroblast-like synoviocytes., PMID:38373844
E7-mediated repression of miR-203 promotes LASP1-dependent proliferation in HPV-positive cervical cancer., PMID:38293147
Astragaloside IV regulates circ_0001615 and miR-873-5p/LASP1 axis to suppress colorectal cancer cell progression., PMID:38230773
m6A-modified circ_0124554 promotes colorectal cancer progression and radioresistance through the miR-1184/LASP1 pathway., PMID:38091882
Identification of the methotrexate resistance-related diagnostic markers in osteosarcoma via adaptive total variation netNMF and multi-omics datasets., PMID:37937197
Knockdown of long non-coding RNA LINC01123 plays a molecular sponge on miR-625-5p to inhibit the process of colorectal cancer cells via LASP1., PMID:37676533
Silenced LASP1 interacts with DNMT1 to promote TJP2 expression and attenuate articular cartilage injury in mice by suppressing TJP2 methylation., PMID:37578083
RNA-binding protein CCDC137 activates AKT signaling and promotes hepatocellular carcinoma through a novel non-canonical role of DGCR8 in mRNA localization., PMID:37542342
Acute monocytic leukemia with KMT2A::LASP1 developed 9 months after diagnosis of acute megakaryoblastic leukemia in a 2-year-old boy., PMID:37314622
Long noncoding RNA PPP1R14B-AS1 imitates microRNA-134-3p to facilitate breast cancer progression by upregulating LIM and SH3 protein 1., PMID:37303940
Exosomal circCOL1A2 from cancer cells accelerates colorectal cancer progression via regulating miR-665/LASP1 signal axis., PMID:37059374
METTL14 promotes fibroblast-like synoviocytes activation via the LASP1/SRC/AKT axis in rheumatoid arthritis., PMID:36878846
Identification of miR-1-3p, miR-143-3p and miR-145-5p association with bone metastasis of Gleason 3+4 prostate cancer and involvement of LASP1 regulation., PMID:36791996
Oridonin Induces Apoptosis in Esophageal Squamous Cell Carcinoma by Inhibiting Cytoskeletal Protein LASP1 and PDLIM1., PMID:36677861
Lasp1 Expression Is Implicated in Embryonic Development of Zebrafish., PMID:36672776
TRIM15 forms a regulatory loop with the AKT/FOXO1 axis and LASP1 to modulate the sensitivity of HCC cells to TKIs., PMID:36670097
LncRNA CBR3-AS1 predicts a poor prognosis and promotes cervical cancer progression through the miR-3163/LASP1 pathway., PMID:36591804
LASP1 in Cellular Signaling and Gene Expression: More than Just a Cytoskeletal Regulator., PMID:36497077
Hepatitis B virus X protein increases LASP1 SUMOylation to stabilize HER2 and facilitate hepatocarcinogenesis., PMID:36473530
Circular RNA hsa_circ_0003892 promotes the development of papillary thyroid carcinoma by regulating the miR-326/LASP1 axis., PMID:36394255
Circ_0001535 Facilitates Tumor Malignant Progression by miR-485-5p/LASP1 Axis in Colorectal Cancer., PMID:36172827
Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis., PMID:36091823
CERS6-AS1 Facilitates Oncogenesis and Restrains Ferroptosis in Papillary Thyroid Carcinoma by Serving as a ceRNA through miR-497-5p/LASP1 Axis., PMID:35777805
Downregulation of long noncoding RNA breast cancer anti-estrogen resistance 4 inhibits cell proliferation, invasion, and migration in esophageal squamous cell carcinoma by regulating the microRNA-181c-5p/LIM and SH3 protein 1 axis., PMID:35611706
[Retracted] MicroRNA‑133a acts as a tumour suppressor in breast cancer through targeting LASP1., PMID:35583001
LIM and SH3 protein 1 (LASP1) differentiates malignant chordomas from less malignant chondrosarcomas., PMID:35507100
miR-218-5p in endometrial microenvironment prevents the migration of ectopic endometrial stromal cells by inhibiting LASP1., PMID:35379225
Hsa_circ_0007142 contributes to cisplatin resistance in esophageal squamous cell carcinoma via miR-494-3p/LASP1 axis., PMID:35312115
Circ_0075804 Regulates the Expression of LASP1 by Targeting miR-1287-5p and Thus Affects the Biological Process of Retinoblastoma., PMID:35285372
The emergence of nebulin repeats and evolution of lasp family proteins., PMID:35224880
Circ_0072088 knockdown contributes to cisplatin sensitivity and inhibits tumor progression by miR-944/LASP1 axis in non-small cell lung cancer., PMID:35106879
Long non-coding RNA (lncRNA) CYTOR promotes hepatocellular carcinoma proliferation by targeting the microRNA-125a-5p/LASP1 axis., PMID:35081873
WTAP-mediated m6A modification of lncRNA DIAPH1-AS1 enhances its stability to facilitate nasopharyngeal carcinoma growth and metastasis., PMID:34999731
LASP1 Induces Epithelial-Mesenchymal Transition in Lung Cancer through the TGF-β1/Smad/Snail Pathway., PMID:34912481
A single-nucleotide mutation within the TBX3 enhancer increased body size in Chinese horses., PMID:34906355
LASP-1 interacts with ErbB2 in ovarian cancer cells., PMID:34881777
For research use only. Not for human or drug use.
