Catalog No.
YHE84301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly2-Lys86
Predicted molecular weight
38.03 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51636
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Caveolin-2, CAV2
CACNA1A loss-of-function affects neurogenesis in human iPSC-derived neural models., PMID:40514452
Spinal Cord Stimulation Alleviates Sensitization of Neuropathic Pain by Upregulating G Protein-Coupled Receptors to Inhibit Overexpression of Cav2.2 and Its Downstream Excitatory Neurotransmitters., PMID:40496674
R and S enantiomers of CBD3063, a CaV2.2 N-type calcium channel modulator, alleviate capsaicin-induced inflammatory pain., PMID:40487899
Disrupting lipid homeostasis with CAV2 in OSCC triggers apoptosis, lipolysis, and mitochondrial dysfunction by transcriptional repression of PPARγ., PMID:40369665
Presynaptic α2δs specify synaptic gain, not synaptogenesis, in the mammalian brain., PMID:40367942
A rich conformational palette underlies human CaV2.1-channel availability., PMID:40268901
The Leucine-Rich Repeat Kinase 2 Variant LRRK2G2019S Up-Regulates L-Type (CaV1.3) Calcium Channel via the CaVβ3 Subunit: Possible Role in the Pathogenesis of Parkinson's Disease., PMID:40244042
Caveolae: Metabolic Platforms at the Crossroads of Health and Disease., PMID:40243482
Imaging Synapse Ultrastructure and Organization with STED Microscopy., PMID:40220098
Targeted Ganglion Delivery of CaV2.2-Mediated Peptide by DNA Nanoflowers for Relieving Myocardial Infarction and Neuropathic Pain., PMID:40128122
CaV2.1 mediates presynaptic dysfunction induced by amyloid β oligomers., PMID:40127100
Interaction between CaV2.1 and Junctophilin3/4 depends on the II-III loop of CaV2.1 and on the α-helical region of Junctophilin3/4., PMID:40118452
Terahertz waves promote Ca2+ transport in the Cav2.1 channel., PMID:40112754
Phenotypic variability in cases with CACNA1A mutation., PMID:40111503
Caveolin 1 and 2 enhance the proliferative capacity of BCAM-positive corneal progenitors., PMID:39994275
Resilience to Endoplasmic Reticulum Stress Mitigates Calcium-Dependent Membrane Hyperexcitability Underlying Late Disease Onset in SCA6., PMID:39975408
The N-type calcium channel rises from the ashes., PMID:39959970
Five-Gene Expression Signature Associated With Acquired FOLFIRI Resistance and Survival in Metastatic Colorectal Cancer., PMID:39954853
Specific presynaptic functions require distinct Drosophila Cav2 splice isoforms., PMID:39951027
CaV2.3 channels in the mouse central medial thalamic nucleus are essential for thalamocortical oscillations and spike wave discharges., PMID:39929891
Complex regulation of Cav2.2 N-type Ca2+ channels by Ca2+ and G-proteins., PMID:39919080
Inactivation of CaV1 and CaV2 channels., PMID:39883005
GABAB Receptor Modulation of Membrane Excitability in Human Pluripotent Stem Cell-Derived Sensory Neurons by Baclofen and α-Conotoxin Vc1.1., PMID:39871624
Exploring the association between familial hemiplegic migraine genes (CACNA1A, ATP1A2 and SCN1A) with migraine and epilepsy: A UK Biobank exome-wide association study., PMID:39781574
Autism-Linked Mutations in α2δ-1 and α2δ-3 Reduce Protein Membrane Expression but Affect Neither Calcium Channels nor Trans-Synaptic Signaling., PMID:39770450
The Neuroprotective Effect of the X Protein of Orthobornavirus Bornaense Type 1 in Amyotrophic Lateral Sclerosis., PMID:39684507
In vitro human ion channel assays predictive of drug-induced seizure., PMID:39661496
C2230, a preferential use- and state-dependent CaV2.2 channel blocker, mitigates pain behaviors across multiple pain models., PMID:39656529
COP5/HKR1 changes ciliary beat pattern and biases cell steering during chemotaxis in Chlamydomonas reinhardtii., PMID:39639079
Pin1 promotes human CaV2.1 channel polyubiquitination by RNF138: pathophysiological implication for episodic ataxia type 2., PMID:39609819
Molecules That Have Rarely Been Studied in Lymphatic Endothelial Cells., PMID:39596293
A structural analysis of the splice-specific functional impact of the pathogenic familial hemiplegic migraine type 1 S218L mutation on Cav2.1 P/Q-type channel gating., PMID:39568055
Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons., PMID:39556620
Peripheral CaV2.2 Channels in the Skin Regulate Prolonged Heat Hypersensitivity during Neuroinflammation., PMID:39433408
Low level exposure to BDE-47 facilitates the development of prostate cancer through TOP2A/LDHA/lactylation positive feedback circuit., PMID:39362459
N-Terminal Capping of the αO-Conotoxin Analogue GeX-2 Improves the Serum Stability and Selectivity toward the Human α9α10 Nicotinic Acetylcholine Receptor., PMID:39361522
Mint/X11 PDZ domains from non-bilaterian animals recognize and bind CaV2 calcium channel C-termini in vitro., PMID:39284887
Voltage-dependent G-protein regulation of CaV2.2 (N-type) channels., PMID:39259796
Silver Nanoparticles (AgNPs) Uptake by Caveolae-Dependent Endocytosis is Responsible for Their Selective Effect Towards Castration Resistant Prostate Cancer., PMID:39258003
Host restriction factor Rab11a limits Porcine deltacoronavirus invasion of cells via fusion peptide-mediated membrane fusion., PMID:39244909
Uncoupling the CRMP2-CaV2.2 Interaction Reduces Pain-Like Behavior in a Preclinical Joint-Pain Model., PMID:39233208
Host restriction factor Rab11a limits porcine epidemic diarrhea virus invasion of cells via fusion peptide-mediated membrane fusion., PMID:39233171
Presynaptic neurons self-tune by inversely coupling neurotransmitter release with the abundance of CaV2 voltage-gated Ca2+ channels., PMID:39172783
A biallelic mutation in CACNA2D2 associated with developmental and epileptic encephalopathy affects calcium channel-dependent as well as synaptic functions of α2δ-2., PMID:39161180
Distinct active zone protein machineries mediate Ca2+ channel clustering and vesicle priming at hippocampal synapses., PMID:39160372
LGI1 Autoantibodies Enhance Synaptic Transmission by Presynaptic Kv1 Loss and Increased Action Potential Broadening., PMID:39141878
Determinants of interactions of a novel next-generation gabapentinoid NVA1309 and mirogabalin with the Cavα2δ-1 subunit., PMID:39113108
Caveolin-2 controls preadipocyte survival in the mitotic clonal expansion for adipogenesis., PMID:39038612
Peptide and Peptidomimetic Inhibitors Targeting the Interaction of Collapsin Response Mediator Protein 2 with the N-Type Calcium Channel for Pain Relief., PMID:39022365
The intracellular C-terminus confers compartment-specific targeting of voltage-gated calcium channels., PMID:38996073
For research use only. Not for human or drug use.
