Catalog No.
YHD86601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro2-Glu84
Predicted molecular weight
37.75 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30047
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GTP cyclohydrolase 1 feedback regulatory protein, GFRP, GTP cyclohydrolase I feedback regulatory protein, p35, GCHFR, GFRP
Integration of biobank-scale genetics and plasma proteomics reveals evidence for causal processes in asthma risk and heterogeneity., PMID:40187354
Duodenal inflammation in common variable immunodeficiency has altered transcriptional response to viruses., PMID:36220400
Biophysical and structural investigation of the regulation of human GTP cyclohydrolase I by its regulatory protein GFRP., PMID:33387654
A hybrid approach reveals the allosteric regulation of GTP cyclohydrolase I., PMID:33229582
Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches., PMID:26014146
Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons., PMID:25642596
The protein partners of GTP cyclohydrolase I in rat organs., PMID:22479495
A novel high-throughput screening assay for discovery of molecules that increase cellular tetrahydrobiopterin., PMID:21693765
The N-terminal peptide of mammalian GTP cyclohydrolase I is an autoinhibitory control element and contributes to binding the allosteric regulatory protein GFRP., PMID:21163945
Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog γ-tocotrienol: evidence of a role for tetrahydrobiopterin., PMID:20950957
Effect of paraquat exposure on nitric oxide-responsive genes in rat mesencephalic cells., PMID:20388547
A polymorphism of the GTP-cyclohydrolase I feedback regulator gene alters transcriptional activity and may affect response to SSRI antidepressants., PMID:20351752
GTP cyclohydrolase I phosphorylation and interaction with GTP cyclohydrolase feedback regulatory protein provide novel regulation of endothelial tetrahydrobiopterin and nitric oxide., PMID:19926872
H(2)O(2) increases de novo synthesis of (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin via GTP cyclohydrolase I and its feedback regulatory protein in vitiligo., PMID:19101819
Deficient BH4 production via de novo and salvage pathways regulates NO responses to cytokines in adult cardiac myocytes., PMID:18835915
Over-expression of GTP-cyclohydrolase 1 feedback regulatory protein attenuates LPS and cytokine-stimulated nitric oxide production., PMID:18372436
GTP cyclohydrolase feedback regulatory protein controls cofactor 6-tetrahydrobiopterin synthesis in the cytosol and in the nucleus of epidermal keratinocytes and melanocytes., PMID:16778797
A yeast 2-hybrid analysis of human GTP cyclohydrolase I protein interactions., PMID:16696853
Evidence for a tetrahydrobiopterin deficit in schizophrenia., PMID:16244500
Reduction of GTP cyclohydrolase I feedback regulating protein expression by hydrogen peroxide in vascular endothelial cells., PMID:15699573
Transcribing the cross-talk of cytokine-induced tetrahydrobiopterin synthesis in endothelial cells., PMID:15692091
Changes in tetrahydrobiopterin levels in endothelial cells and adult cardiomyocytes induced by LPS and hydrogen peroxide--a role for GFRP?, PMID:15649650
Structural basis of biopterin-induced inhibition of GTP cyclohydrolase I by GFRP, its feedback regulatory protein., PMID:15448133
The mechanism of potent GTP cyclohydrolase I inhibition by 2,4-diamino-6-hydroxypyrimidine: requirement of the GTP cyclohydrolase I feedback regulatory protein., PMID:15292175
Cerebrospinal fluid pterins and folates in Aicardi-Goutières syndrome: a new phenotype., PMID:12963755
Role of human GTP cyclohydrolase I and its regulatory protein in tetrahydrobiopterin metabolism., PMID:12607127
Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP., PMID:11818540
Bacterial lipopolysaccharide down-regulates expression of GTP cyclohydrolase I feedback regulatory protein., PMID:11799107
Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP., PMID:11580249
Preparation and crystallization of the stimulatory and inhibitory complexes of GTP cyclohydrolase I and its feedback regulatory protein GFRP., PMID:11468403
Ligand binding to the inhibitory and stimulatory GTP cyclohydrolase I/GTP cyclohydrolase I feedback regulatory protein complexes., PMID:11274478
Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS., PMID:10435048
GTP cyclohydrolase I feedback regulatory protein is expressed in serotonin neurons and regulates tetrahydrobiopterin biosynthesis., PMID:9930739
Perturbed epidermal pterin metabolism in Hermansky-Pudlak syndrome., PMID:9740249
GTP cyclohydrolase I inhibition by the prototypic inhibitor 2, 4-diamino-6-hydroxypyrimidine. Mechanisms and unanticipated role of GTP cyclohydrolase I feedback regulatory protein., PMID:9694862
Decameric GTP cyclohydrolase I forms complexes with two pentameric GTP cyclohydrolase I feedback regulatory proteins in the presence of phenylalanine or of a combination of tetrahydrobiopterin and GTP., PMID:9685352
GTP cyclohydrolase I feedback regulatory protein is a pentamer of identical subunits. Purification, cDNA cloning, and bacterial expression., PMID:9092499
Purification and cloning of the GTP cyclohydrolase I feedback regulatory protein, GFRP., PMID:8702680
For research use only. Not for human or drug use.
