Catalog No.
YHD60901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg123-Gly208
Predicted molecular weight
23.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23942
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Peripherin-2, Retinal degeneration slow protein, Tetraspanin-22, Tspan-22, PRPH2, PRPH, RDS, TSPAN22
Clinical Spectrum and Molecular Characteristics of Inherited Ocular Diseases in a Cohort of Pediatric Patients With Infantile Nystagmus Syndrome., PMID:40232708
PARP inhibition preserves cone photoreceptors in rd2 retina., PMID:40170065
Inherited retinal degeneration in Malay and Indian populations of Singapore and Malaysia: a prospective multicentre study., PMID:40101946
The PRPH2 D2 Loop: Biochemical Insights and Implications in Disease., PMID:39930215
Phenotypic and Genetic Heterogeneity of a Pakistani Cohort of 15 Consanguineous Families Segregating Variants in Leber Congenital Amaurosis-Associated Genes., PMID:39766915
Clinical and Imaging Characteristics of PRPH2 Retinopathies in a Longitudinal Cohort and Diagnostic Implications., PMID:39693084
Epiretinal Membrane: Correlations Among Clinical, Immunohistochemical, and Biochemical Features and Their Prognostic Implications., PMID:39661356
Phenotypic and Genetic Spectrum in 309 Consecutive Pediatric Patients with Inherited Retinal Disease., PMID:39596324
Optimization of HITI-Mediated Gene Insertion for Rhodopsin and Peripherin-2 in Mouse Rod Photoreceptors: Targeting Dominant Retinitis Pigmentosa., PMID:39556087
PRPH2-ASSOCIATED RETINAL DISEASES: A SYSTEMATIC REVIEW OF PHENOTYPIC FINDINGS., PMID:39515456
Current and Future Directions in Developing Effective Treatments for PRPH2-Associated Retinal Diseases: A Workshop Report., PMID:39382871
A new mouse model for PRPH2 pattern dystrophy exhibits functional compensation prior and subsequent to retinal degeneration., PMID:39231530
Using Multimodal Imaging to Refine the Phenotype of PRPH2-associated Retinal Degeneration., PMID:39089460
HBS1L deficiency causes retinal dystrophy in a child and in a mouse model associated with defective development of photoreceptor cells., PMID:38966981
NR2E3 inhibits the inflammation and apoptosis in diabetic retinopathy by regulating the AHR/IL-17A signaling pathway., PMID:38884674
Downregulation of rhodopsin is an effective therapeutic strategy in ameliorating peripherin-2-associated inherited retinal disorders., PMID:38834544
Sex Distributions in Non-ABCA4 Autosomal Macular Dystrophies., PMID:38700873
[Role of endosomal pathway in the ciliary transport and the membrane organization of outer segment disc membrane in photoreceptors]., PMID:38684400
Towards Uncovering the Role of Incomplete Penetrance in Maculopathies through Sequencing of 105 Disease-Associated Genes., PMID:38540785
PRPH2-Related Retinal Dystrophies: Mutational Spectrum in 103 Families from a Spanish Cohort., PMID:38474159
Novel heterozygous PRPH2 variant identified in a patient with spinocerebellar ataxia type 14 and macular dystrophy., PMID:38419591
Genetics of Retinitis Pigmentosa and Other Hereditary Retinal Disorders in Western Switzerland., PMID:38160664
Identification and cellular localization in Xenopus laevis photoreceptors of three Peripherin-2 family members, Prph2, Rom1 and Gp2l, which arose from gene duplication events in the common ancestors of jawed vertebrates., PMID:38158174
Structure-function correlation of retinal photoreceptors in PRPH2-associated central areolar choroidal dystrophy patients assessed by high-resolution scanning laser imaging and microperimetry., PMID:38041245
ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims., PMID:37991486
Prph2 knock-in mice recapitulate human central areolar choroidal dystrophy retinal degeneration and exhibit aberrant synaptic remodeling and microglial activation., PMID:37914688
ROM1 is redundant to PRPH2 as a molecular building block of photoreceptor disc rims., PMID:37693615
Novel IMPG2 variant causing adult macular vitelliform dystrophy: A case report., PMID:37661650
Re: Heath Jeffery et al.: Analysis of the outer retinal bands in ABCA4-associated and PRPH2-associated retinopathy using OCT (Opthalmol Retina. 2023 May 18;S2468-6530(23)00209-9. doi: 10.1016/j.oret.2023.05.010. Online ahead of print.)., PMID:37642630
Primary versus Secondary Elevations in Fundus Autofluorescence., PMID:37569703
Choroidal neovascularization associated with butterfly-shaped pattern dystrophy - a case report., PMID:37522013
Comparative study of PRPH2 D2 loop mutants reveals divergent disease mechanism in rods and cones., PMID:37466729
The Role of Peripherin-2/ROM1 Complexes in Photoreceptor Outer Segment Disc Morphogenesis., PMID:37440045
Generation of an Avian Myeloblastosis Virus (AMV) Reverse Transcriptase Prime Editor., PMID:37440022
Analysis of the Outer Retinal Bands in ABCA4 and PRPH2-Associated Retinopathy using OCT., PMID:37209970
Clinical Heterogeneity in Two Siblings Harbouring a Heterozygous PRPH2 Pathogenic Variant., PMID:37164409
New Insight into the Genotype-Phenotype Correlation of PRPH2-Related Diseases Based on a Large Chinese Cohort and Literature Review., PMID:37047703
PRPH2 mutation c.582-1G>A causing adult-onset macular dystrophy with a benign concentric annular macular dystrophy phenotype in a family., PMID:39298723
Sub-cellular level resolution of common genetic variation in the photoreceptor layer identifies continuum between rare disease and common variation., PMID:36848389
PRPH2-Associated Retinopathy: Novel Variants and Genotype-Phenotype Correlations., PMID:36563963
Cryo-EM structures of peripherin-2 and ROM1 suggest multiple roles in photoreceptor membrane morphogenesis., PMID:36351012
Ca2+ and Mg2+ Influence the Thermodynamics of Peptide-Membrane Interactions., PMID:36115657
PRPF31 interacts with PRPH2 confirmed by co-immunoprecipitation and co-localization., PMID:36088804
Two cases of unilateral cone-rod dysfunction presenting in adult females., PMID:36070159
Clinical-genetic findings in a group of subjects with macular dystrophies due to mutations in rare inherited retinopathy genes., PMID:35947183
Genome-wide CRISPR knockout screening identified G protein pathway suppressor 2 as a novel tumor suppressor for uveal melanoma metastasis., PMID:35941228
Photoreceptor and Retinal Pigment Epithelium Relationships in Eyes With Vitelliform Macular Dystrophy Revealed by Multimodal Adaptive Optics Imaging., PMID:35900727
Delineating the Clinical Phenotype of Patients With the c.629C>G, p.Pro210Arg Mutation in Peripherin-2., PMID:35861669
For research use only. Not for human or drug use.
