Catalog No.
YHD58702
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser342-Leu588
Predicted molecular weight
29.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P23508
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Colorectal mutant cancer protein, Protein MCC, MCC
Effect of temperature and protein concentration on the protein types within the ultracentrifugation supernatant of liquid micellar casein concentrate., PMID:37641294
Two germline mutations can serve as genetic susceptibility screening makers for a lung adenocarcinoma family., PMID:36781503
MCC is a centrosomal protein that relocalizes to non-centrosomal apical sites during intestinal cell differentiation., PMID:36217793
Viscosity changes and gel formation during storage of liquid micellar casein concentrates., PMID:34531054
Association of VAMP5 and MCC genetic polymorphisms with increased risk of Hirschsprung disease susceptibility in Southern Chinese children., PMID:29695640
The Sign of Nuclear Magnetic Resonance Chemical Shift Difference as a Determinant of the Origin of Binding Selectivity: Elucidation of the Position Dependence of Phosphorylation in Ligands Binding to Scribble PDZ1., PMID:29144123
'MCC' protein interacts with E-cadherin and β-catenin strengthening cell-cell adhesion of HCT116 colon cancer cells., PMID:29035389
Therapeutic Inhibition of miR-4260 Suppresses Colorectal Cancer via Targeting MCC and SMAD4., PMID:28638476
[A novel compound heterozygous mutation causing 3-methylcrotonyl-CoA carboxylase deficiency]., PMID:27577216
Allele-specific expression of mutated in colorectal cancer (MCC) gene and alternative susceptibility to colorectal cancer in schizophrenia., PMID:27226254
Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-catenin(Y654) are associated with breast carcinoma: Clinical and prognostic significance., PMID:27208794
Proteogenomic Analysis Identifies a Novel Human SHANK3 Isoform., PMID:25997006
Exome-wide Sequencing Shows Low Mutation Rates and Identifies Novel Mutated Genes in Seminomas., PMID:25597018
[Follow up and gene mutation analysis in cases suspected as 3-methylcrotonyl-coenzyme A carboxylase deficiency by neonatal screening]., PMID:25190158
MCC inhibits beta-catenin transcriptional activity by sequestering DBC1 in the cytoplasm., PMID:24824780
MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer., PMID:23913442
Endogenous retrotransposition activates oncogenic pathways in hepatocellular carcinoma., PMID:23540693
The PDZ-binding motif of MCC is phosphorylated at position -1 and controls lamellipodia formation in colon epithelial cells., PMID:22480440
Mutated in colorectal cancer protein modulates the NFκB pathway., PMID:22213290
p31comet-mediated extraction of Mad2 from the MCC promotes efficient mitotic exit., PMID:22100920
Association of APC and MCC polymorphisms with increased breast cancer risk in an Indian population., PMID:21279955
C terminus of Nce102 determines the structure and function of microdomains in the Saccharomyces cerevisiae plasma membrane., PMID:20581291
Furrow-like invaginations of the yeast plasma membrane correspond to membrane compartment of Can1., PMID:19638406
MCC, a new interacting protein for Scrib, is required for cell migration in epithelial cells., PMID:19555689
Mutated in colorectal cancer, a putative tumor suppressor for serrated colorectal cancer, selectively represses beta-catenin-dependent transcription., PMID:18591935
A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway., PMID:14743216
[Genotyping of multiple genetic alterations of intrahepatic cholangiocarcinoma]., PMID:11798885
[Identification of a novel MCC-homologue, MCC2, which interacts with PDZ-domain protein AIE-75]., PMID:11766388
Interaction of MCC2, a novel homologue of MCC tumor suppressor, with PDZ-domain Protein AIE-75., PMID:11311560
Three submicroscopic deletions at the APC locus and their rapid detection by quantitative-PCR analysis., PMID:10482959
Localization of MCC (mutated in colorectal cancer) in various tissues of mice and its involvement in cell differentiation., PMID:10449536
Absence of APC gene mutation in the mutation cluster region in hepatocellular carcinoma., PMID:10381126
Antigen-pulsed CD8alpha+ dendritic cells generate an immune response after subcutaneous injection without homing to the draining lymph node., PMID:9927521
A 33 bp minisatellite repeat upstream of the 'mutated in colon cancer' gene at chromosome 5q21., PMID:9694282
Duplication of an approximately 1.5 Mb DNA segment at chromosome 5q22 indicates the locus of a new tumour gene in nonpapillary renal cell carcinomas., PMID:9070658
Genetic evidence for the multicentric origin of synchronous multiple gastric carcinoma., PMID:9121123
Somatic mutations of the APC gene in sporadic hepatoblastomas., PMID:8764128
MCC, a cytoplasmic protein that blocks cell cycle progression from the G0/G1 to S phase., PMID:8626604
[Characterization of the MCC gene product]., PMID:8920660
MaeIII polymorphism in sequence encoding 3' untranslated region of the MCC gene., PMID:1347926
Detection of multiallele polymorphisms within gene sequences by GC-clamped denaturing gradient gel electrophoresis., PMID:1539594
Insertion/deletion polymorphism and other restriction fragment length polymorphisms in the MCC gene., PMID:1347524
Colon cancer. Consider the coiled coil..., PMID:1645848
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers., PMID:1848370
For research use only. Not for human or drug use.
