Catalog No.
YHD41601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser122-Gly360
Predicted molecular weight
27.84 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P20749
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
BCL-3, B-cell lymphoma 3 protein, Proto-oncogene BCL3, BCL4, BCL3, D19S37
Therapeutic Insights Into a Case-Control Approach to B-cell Lymphoma 3 (BCL3)-Encoded Protein by Exploring Immune Modulation and Clinical Strategies in Oral Carcinomas., PMID:40486320
Bcl-3 depletion prevent autoimmune hepatitis of mice through CXCR4/CXCL12 pathway., PMID:40435820
Integrative Transcriptomic Profiling Identifies TNF and IL1B as Candidate Key Early-Response Genes in Macrophages Infected with Smooth Brucella Using a Comprehensive Bioinformatic Approach., PMID:40427768
Regulation and Function of the Atypical IκBs-Bcl-3, IκBNS, and IκBζ-in Lymphocytes and Autoimmunity., PMID:40359334
Liver-specific Bcl3 Knockout Alleviates Acetaminophen-induced Liver Injury by Activating Nrf2 Pathway in Male Mice., PMID:40015625
Immune checkpoint protein PD-L1 promotes transcription of angiogenic and oncogenic proteins IL-8, Bcl3, and STAT1 in ovarian cancer cells., PMID:39988077
An optimised Bcl-3 inhibitor for melanoma treatment., PMID:39943627
Determination of IL-17, BCL-3 and IκBζ expression levels in the gingival crevicular fluid of psoriasis patients., PMID:39786665
Identification of BCL3 as a biomarker for chondrocyte programmed cell death in osteoarthritis., PMID:39676743
BCL3, GBP1, IFI16, and CCR1 as potential brain-derived biomarkers for parietal grey matter lesions in multiple sclerosis., PMID:39557900
METTL3 facilitates kidney injury through promoting IRF4-mediated plasma cell infiltration via an m6A-dependent manner in systemic lupus erythematosus., PMID:39501302
Enhancing cell death in B-cell malignancies through targeted inhibition of Bcl-3., PMID:39327470
The effect of the HMGB1/RAGE/TLR4/NF-κB signalling pathway in patients with idiopathic epilepsy and its relationship with toxoplasmosis., PMID:39046369
Molecular landscape of mature B-cell lymphoproliferative disorders with BCL3-translocation: A Groupe Francophone de Cytogénétique Hématologique (GFCH)/French Innovative Leukemia Organization (FILO) study., PMID:38817040
Loss of Bcl-3 regulates macrophage polarization by promoting macrophage glycolysis., PMID:38804132
The atypical IκB family member Bcl3 determines differentiation and fate of intestinal RORγt+ regulatory T-cell subsets., PMID:38663461
LTBP2 regulates cisplatin resistance in GC cells via activation of the NF-κB2/BCL3 pathway., PMID:38577985
The water-soluble subfraction from Artemisia argyi alleviates LPS-induced inflammatory responses via multiple pathways and targets in vitro and in vivo., PMID:38380576
Porcine β-Defensin 114: Creating a Dichotomous Response to Inflammation., PMID:38256090
Discovery of a small molecule that inhibits Bcl-3-mediated cyclin D1 expression in melanoma cells., PMID:38238702
Multifaceted roles for BCL3 in cancer: a proto-oncogene comes of age., PMID:38195591
Role of the redox state of the Pirin-bound cofactor on interaction with the master regulators of inflammation and other pathways., PMID:38033031
Novel identification of t(14;18)(q32;q21)/IGH::MALT1 in chronic lymphocytic leukaemia., PMID:38031233
Knockdown of BCL-3 Attenuates Inflammatory Response in Intracerebral Hemorrhage Through an rBMECs/MGs Microenvironment., PMID:38006962
Solvent-free synthesis and in-silico molecular docking study of (E)-3-(β-C-glycosylmethylidene)-N-aryl/alkyl succinimides., PMID:37982163
Bcl-3 regulates T cell function through energy metabolism., PMID:37794349
B-cell-derived IL-10 promotes allergic sensitization in asthma regulated by Bcl-3., PMID:37653127
Kidney Damage in Long COVID: Studies in Experimental Mice., PMID:37626956
IĸB Protein BCL3 as a Controller of Osteogenesis and Bone Health., PMID:37410754
IFNγ induces Bcl3 expression by JAK1/STAT1/p65 signaling, resulting in increased IL-8 expression in ovarian cancer cells., PMID:37151134
Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR-1343-3p/Bcl-3 axis through TGFβ/Smad3/EMT signaling., PMID:37132942
Melanoma Clinical Decision Support System: An Artificial Intelligence-Based Tool to Diagnose and Predict Disease Outcome in Early-Stage Melanoma Patients., PMID:37046835
Structures of NF-κB p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation., PMID:36779700
Identification of methylation-driven genes, circulating miRNAs and their potential regulatory mechanisms in gestational diabetes mellitus., PMID:36777869
Restoring Age-Related Cognitive Decline through Environmental Enrichment: A Transcriptomic Approach., PMID:36497123
Knockdown of Bcl-3 alleviates psoriasis and dyslipidemia comorbidity by regulating Akt pathway., PMID:36335454
Draft Genome Sequence of Alkalihalobacillus clausii Strain AXA-BCL3, Isolated from the Sahastradhara Springs of Uttarakhand, India., PMID:36326499
NF kappa B regulator Bcl3 controls development and function of classical dendritic cells required for resistance to Toxoplasma gondii., PMID:36318581
Bcl-3 regulates the function of Th17 cells through raptor mediated glycolysis metabolism., PMID:36159779
Atypical IκB Bcl3 enhances the generation of the NF-κB p52 homodimer., PMID:35990614
Multiple roles for Bcl-3 in mammary gland branching, stromal collagen invasion, involution and tumor pathology., PMID:35681213
Hepatocyte Bcl-3 protects from death-receptor mediated apoptosis and subsequent acute liver failure., PMID:35641486
The immune regulation of BCL3 in glioblastoma with mutated IDH1., PMID:35488886
EGFR ligands synergistically increase IL-17A-induced expression of psoriasis signature genes in human keratinocytes via IκBζ and Bcl3., PMID:35411943
Bcl-3: A Double-Edged Sword in Immune Cells and Inflammation., PMID:35355979
LPS/Bcl3/YAP1 signaling promotes Sox9+HNF4α+ hepatocyte-mediated liver regeneration after hepatectomy., PMID:35351855
Neuroprotective effects of carvacrol against cadmium-induced neurotoxicity in rats: role of oxidative stress, inflammation and apoptosis., PMID:35316447
Ferroptosis-Related APOE, BCL3 and ALOX5AP Gene Polymorphisms are Associated with the Risk of Thyroid Cancer., PMID:35241926
BCL3 expression is strongly associated with the occurrence of breast cancer relapse under tamoxifen treatment in a retrospective cohort study., PMID:35020071
The enhancer rare germline variation rs548071605 contributes to lung cancer development., PMID:34859522
For research use only. Not for human or drug use.
