Catalog No.
YHD16001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys17-Cys465
Predicted molecular weight
51.81 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P16233
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pancreatic triacylglycerol lipase, PL, PTL, Pancreatic lipase, 3.1.1.3, PNLIP
Gasdermin D-Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis., PMID:40439590
Combining kinetics and in silico approaches to evaluate bromhexine as an anti-pancreatic lipase agent for obesity management., PMID:40419556
Promising pancreatic lipase inhibitory activity of a novel tetrapeptide isolated from endophytic Fusarium incarnatum., PMID:40415016
Inhibition of pancreatic lipase and cholesterol by hawthorn extract: A study of binding mechanisms and inhibitor screening., PMID:40316100
Discover the Power of Lithospermic Acid as Human Carbonic Anhydrase VA and Pancreatic Lipase Inhibitor Through In Silico and In Vitro Studies., PMID:40257393
Role of pancreatic lipase inhibition in obesity treatment: mechanisms and challenges towards current insights and future directions., PMID:40016558
Effect of Silibinin on Human Pancreatic Lipase Inhibition and Gut Microbiota in Healthy Volunteers: A Randomized Controlled Trial., PMID:39684564
Identification of a pancreatic juice-specific fluorescent probe through 411 probes activated by aminopeptidases/proteases or phosphatases/phosphodiesterases., PMID:39632145
Convergent relaxation of molecular constraint in herbivores reveals the changing role of liver and kidney functions across mammalian diets., PMID:39578099
Exploring flavonoid derivatives as potential pancreatic lipase inhibitors for obesity management: An in silico and in vitro study., PMID:39394546
Fluorescence lifetime imaging of human pancreatic lipase activity using a novel probe for early diagnosis of severe acute pancreatitis., PMID:39332173
Novel Role of the ALPI Gene Associated with Constipation Caused by Complement Component 3 Deficiency., PMID:39273477
Modeling protease-sensitive human pancreatic lipase mutations in the mouse ortholog., PMID:39265662
Discovery of natural anthraquinones as potent inhibitors against pancreatic lipase: structure-activity relationships and inhibitory mechanism., PMID:39223707
Discovery of Curcuminoids as Pancreatic Lipase Inhibitors from Medicine-and-Food Homology Plants., PMID:39125445
Discovery of baicalein derivatives as novel inhibitors against human pancreatic lipase: Structure-activity relationships and inhibitory mechanisms., PMID:38945336
Exploring the enigmatic association between PNLIP variants and risk of chronic pancreatitis in a large Chinese cohort., PMID:38485544
Pancreatic lipase and its related proteins: where are we now?, PMID:38081381
Characterization of novel PNLIP variants in congenital pancreatic lipase deficiency., PMID:37926600
Meta-analysis of lean and obese RNA-seq datasets to identify genes targeting obesity., PMID:37808366
Identification of hits as anti-obesity agents against human pancreatic lipase via docking, drug-likeness, in-silico ADME(T), pharmacophore, DFT, molecular dynamics, and MM/PB(GB)SA analysis., PMID:37735906
Piper longum Constituents Induce PANC-1 Human Pancreatic Cancer Cell Death under Nutrition Starvation., PMID:37612242
Comparative transcriptomic analysis reveals the underlying molecular mechanism in high-fat diet-induced islet dysfunction., PMID:37293973
Identification of protease-sensitive but not misfolding PNLIP variants in familial and hereditary pancreatitis., PMID:37270400
A rationally engineered specific near-infrared fluorogenic substrate of human pancreatic lipase for functional imaging and inhibitor screening., PMID:37092796
Preclinical mouse model of a misfolded PNLIP variant develops chronic pancreatitis., PMID:36631248
In vitro anti-obesity activity by pancreatic lipase inhibition - Simple HPLC approach using EVOO as natural substrate., PMID:36583522
Acute systemic knockdown of Atg7 is lethal and causes pancreatic destruction in shRNA transgenic mice., PMID:35343375
Transcriptome analysis provides insight into the anti-diabetic mechanism of theaflavins in high-fat diet and streptozotocin-induced mice., PMID:35106523
Genetic analysis of pancreatic phospholipase A2 (PLA2G1B) in patients with chronic pancreatitis., PMID:35031208
Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis., PMID:35013273
Pancreatic lipase: why laboratory community does not take enough care of this clinically important test?, PMID:34533007
Missense PNLIP mutations impeding pancreatic lipase secretion cause protein misfolding and endoplasmic reticulum stress., PMID:34373204
Performance, Serum Biochemical and Immunological Parameters, and Digestive Enzyme and Intestinal Barrier-Related Gene Expression of Broiler Chickens Fed Fermented Fava Bean By-Products as a Substitute for Conventional Feed., PMID:34336981
Structure and Function of Pancreatic Lipase-Related Protein 2 and Its Relationship With Pathological States., PMID:34290745
Impact of Fermented or Enzymatically Fermented Dried Olive Pomace on Growth, Expression of Digestive Enzyme and Glucose Transporter Genes, Oxidative Stability of Frozen Meat, and Economic Efficiency of Broiler Chickens., PMID:34124216
Patients With Coronavirus Disease 2019 Interstitial Pneumonia Exhibit Pancreatic Hyperenzymemia and Not Acute Pancreatitis., PMID:34016891
Thymol nanoemulsion promoted broiler chicken's growth, gastrointestinal barrier and bacterial community and conferred protection against Salmonella Typhimurium., PMID:33833292
Lipase elevation and type 1 diabetes mellitus related to immune checkpoint inhibitor therapy - A multicentre study of 90 patients from the German Dermatooncology Group., PMID:33812141
Pancreatic lipase and α-amylase inhibitory activity of extracts from selected plant materials after gastrointestinal digestion in vitro., PMID:33773461
Inhibitory kinetics and mechanism of pentacyclic triterpenoid from endophytic Colletotrichum gigasporum against pancreatic lipase., PMID:33561462
Pancreatic lipase inhibitors: The road voyaged and successes., PMID:33515565
Effects of graded levels of microbial fermented or enzymatically treated dried brewer's grains on growth, digestive and nutrient transporter genes expression and cost effectiveness in broiler chickens., PMID:33153443
Hyperlipasemia and Potential Pancreatic Injury Patterns in COVID-19: A Marker of Severity or Innocent Bystander?, PMID:33129845
Predictive Value of Acute Pancreatitis Diagnosis Code in Diabetic Patients Is Similar to Nondiabetic Patients., PMID:33122536
Exploring Aurone Derivatives as Potential Human Pancreatic Lipase Inhibitors through Molecular Docking and Molecular Dynamics Simulations., PMID:33066044
Hydromethanolic Extracts from Adansonia digitata L. Edible Parts Positively Modulate Pathophysiological Mechanisms Related to the Metabolic Syndrome., PMID:32575811
Isolation and identification of cholesterol esterase and pancreatic lipase inhibitory peptides from brewer's spent grain by consecutive chromatography and mass spectrometry., PMID:32515459
Lipase Inhibitors for Obesity: A Review., PMID:32485574
An intact C-terminal end of albumin is required for its long half-life in humans., PMID:32313072
For research use only. Not for human or drug use.
