Catalog No.
YHC78801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln183
Predicted molecular weight
22.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P10114
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ras-related protein Rap-2a, 3.6.5.2, RbBP-30, RAP2A
Rap2a promotes cardiac fibrosis and exacerbates myocardial infarction through the TNIK/Merlin/YAP axis., PMID:40332594
Genome-wide identification and expression profile analysis of the Ras superfamily genes in eastern honeybee (Apis cerana)., PMID:39985837
The role of RAP2 in regulation of cell volume on bone marrow mesenchymal stem cell fate determination., PMID:39903386
BRAF regulates circPSD3/miR-526b/RAP2A axis to hinder papillary thyroid carcinoma progression., PMID:39838328
LINC00963 Represses Osteogenic Differentiation of hBMSCs via the miR-10b-5p/RAP2A/AKT Axis., PMID:39068933
Elucidating sleep disorders: a comprehensive bioinformatics analysis of functional gene sets and hub genes., PMID:38919616
Influence of stocking density on the growth, immune and physiological responses, and cultivation environment of white-leg shrimp (Litopenaeus vannamei) in biofloc systems., PMID:38750082
Interplay of RAP2 GTPase and the cytoskeleton in Hippo pathway regulation., PMID:38574891
Artemisia carvifolia Buch silver nanoparticles downregulate the Rap2A gene in liver cancer., PMID:38057542
Three-dimensional chromatin landscapes in hepatocellular carcinoma associated with hepatitis B virus., PMID:37925679
Transcriptomic analyses of ovarian clear-cell carcinoma with concurrent endometriosis., PMID:37621654
Altered G-Protein Transduction Protein Gene Expression in the Testis of Infertile Patients with Nonobstructive Azoospermia., PMID:37610843
Loss of RAP2A Aggravates Cartilage Degradation in TMJOA via YAP Signaling., PMID:36366779
Circ_0001667 Promotes Adriamycin Resistance and Malignant Progression via Targeting the miR-193a-5p/Rap2A Molecular Axis in Breast Cancer., PMID:36289041
miR-33a-5p Targets RAP2A to Mediate the Sensitivity of Gastric Cancer Cells to 5-FU., PMID:36046374
Potential synbiotic effects of a Bacillus mixture and chitosan on growth, immune responses and VP(AHPND) resistance in Pacific white shrimp (Litopenaeus vannamei, Boone, 1931)., PMID:35835382
TGF-β1-induced RAP2 regulates invasion in pancreatic cancer., PMID:35538031
ArhGEF12 activates Rap1A and not RhoA in human dermal microvascular endothelial cells to reduce tumor necrosis factor-induced leak., PMID:35294066
Ubiquitylation by Rab40b/Cul5 regulates Rap2 localization and activity during cell migration., PMID:35293963
Simulated Microgravity Increases the Permeability of HUVEC Monolayer through Up-Regulation of Rap1GAP and Decreased Rap2 Activation., PMID:35054818
β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity., PMID:34847077
Bioinformatics Analysis Using ATAC-seq and RNA-seq for the Identification of 15 Gene Signatures Associated With the Prediction of Prognosis in Hepatocellular Carcinoma., PMID:34760691
Tumor suppressive role of miR-33a-5p in pancreatic ductal adenocarcinoma cells by directly targeting RAP2A., PMID:34090323
RAP2A promotes apoptosis resistance of hepatocellular carcinoma cells via the mTOR pathway., PMID:34018090
A comprehensive analysis of RAS-effector interactions reveals interaction hotspots and new binding partners., PMID:33930461
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics., PMID:33514835
lncRNA FLVCR1‑AS1 drives colorectal cancer progression via modulation of the miR‑381/RAP2A axis., PMID:33313944
Abnormal expression of Rap2A as a prognostic marker for human breast cancer., PMID:33015796
Metformin Decreases Insulin Resistance in Type 1 Diabetes Through Regulating p53 and RAP2A in vitro and in vivo., PMID:32606605
Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling., PMID:32321834
MiR-140 targets RAP2A to enable the proliferation of insulin-treated ovarian granulosa cells., PMID:32024547
Neratinib degrades MST4 via autophagy that reduces membrane stiffness and is essential for the inactivation of PI3K, ERK1/2, and YAP/TAZ signaling., PMID:31912905
Knockdown of RAP2A gene expression suppresses cisplatin resistance in gastric cancer cells., PMID:31897147
Genome Scan for Genomic Regions and Genes Associated with Growth Trait in Pacific White Shrimp Litopeneaus vannamei., PMID:30887268
Both knock-down and overexpression of Rap2a small GTPase in macrophages result in impairment of NF-κB activity and inflammatory gene expression., PMID:30851634
Inflammation-dependent ISG15 upregulation mediates MIA-induced dendrite damages and depression by disrupting NEDD4/Rap2A signaling., PMID:30826466
Role of JAM-A tyrosine phosphorylation in epithelial barrier dysfunction during intestinal inflammation., PMID:30625033
RAP2 mediates mechanoresponses of the Hippo pathway., PMID:30135582
Phosphorylation of synaptic GTPase-activating protein (synGAP) by polo-like kinase (Plk2) alters the ratio of its GAP activity toward HRas, Rap1 and Rap2 GTPases., PMID:30049443
TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis., PMID:29940807
Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains., PMID:29706584
Ras-related protein Rap2c promotes the migration and invasion of human osteosarcoma cells., PMID:29552178
Insights into exchange factor directly activated by cAMP (EPAC) as potential target for cancer treatment., PMID:29417338
Disrupting CD147-RAP2 interaction abrogates erythrocyte invasion by Plasmodium falciparum., PMID:29352039
Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer., PMID:29309643
Dysregulation of junctional adhesion molecule-A contributes to ethanol-induced barrier disruption in intestinal epithelial cell monolayers., PMID:29208693
Rufy3 is an adapter protein for small GTPases that activates a Rac guanine nucleotide exchange factor to control neuronal polarity., PMID:29089386
Rap2a serves as a potential prognostic indicator of renal cell carcinoma and promotes its migration and invasion through up-regulating p-Akt., PMID:28747626
Guanine nucleotide exchange factor Epac2-dependent activation of the GTP-binding protein Rap2A mediates cAMP-dependent growth arrest in neuroendocrine cells., PMID:28546426
Regulation of glioma migration and invasion via modification of Rap2a activity by the ubiquitin ligase Nedd4-1., PMID:28405688