Catalog No.
YHC46601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser41-Gly286
Predicted molecular weight
29.95 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P0C2W1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
F-box/SPRY domain-containing protein 1, F-box only protein 45, hFbxo45, FBXO45, FBX45
SETD7 drives diabetic endothelial dysfunction through FBXO45-mediated GPX4 ubiquitylation., PMID:40275362
FBXO45 restricts HIV-1 replication by inducing SQSTM1/p62-mediated autophagic degradation of Tat., PMID:39936917
The FBXO45-GEF-H1 Axis Controls Germinal Center Formation and B-cell Lymphomagenesis., PMID:39820335
Loss of Fbxo45 in AT2 cells leads to insufficient histone supply and initiates lung adenocarcinoma., PMID:39672818
FBXO45 Knockdown Restrains the Progression of Bladder Cancer via the ERK/Cyclin D1/CDK4 Pathway., PMID:39238305
Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics in aged mice., PMID:39225086
Correlation of FBXO45 Expression Levels with Cancer Severity by ZEB1 Ubiquitin in Non-Small-Cell Lung Cancer., PMID:39016138
FBXO45 levels regulated ferroptosis renal tubular epithelial cells in a model of diabetic nephropathy by PLK1., PMID:38841177
A Predictive Model Based on the FBXO Family Reveals the Significance of Cyclin F in Hepatocellular Carcinoma., PMID:38812312
Fbxo45 facilitates the malignant progression of breast cancer by targeting Bim for ubiquitination and degradation., PMID:38773471
Establishment of a diagnostic model of endometriosis based on disulfidptosis-related genes., PMID:38644543
Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function., PMID:38289221
LncRNA MEG8 ameliorates Parkinson's disease neuro-inflammation through miR-485-3p/FBXO45 axis., PMID:37814093
Ubiquitin ligase and signalling hub MYCBP2 is required for efficient EPHB2 tyrosine kinase receptor function., PMID:37693478
Identification of F-Box/SPRY Domain-Containing Protein 1 (FBXO45) as a Prognostic Biomarker for TMPRSS2-ERG-Positive Primary Prostate Cancers., PMID:36980776
Identification of hypertrophy-modulating Cullin-RING ubiquitin ligases in primary cardiomyocytes., PMID:36969608
An optimized protocol to detect protein ubiquitination and activation by ubiquitination assay in vivo and CCK-8 assay., PMID:36964909
In vivo analysis of FBXO45-mediated fibrosis and liver tumorigenesis in a chemically induced mouse model of hepatocellular carcinoma., PMID:36853700
The E3 ligase subunit FBXO45 binds the interferon-λ receptor and promotes its degradation during influenza virus infection., PMID:36379255
Fbxo45 promotes the malignant development of esophageal squamous cell carcinoma by targeting GGNBP2 for ubiquitination and degradation., PMID:36127399
CACNA1C-AS2 inhibits cell proliferation and suppresses cell migration and invasion via targeting FBXO45 and PI3K/AKT/mTOR pathways in glioma., PMID:36038736
Fbxo45-mediated NP-STEP46 degradation via K6-linked ubiquitination sustains ERK activity in lung cancer., PMID:35838331
E3 ubiquitin ligase RBX1 drives the metastasis of triple negative breast cancer through a FBXO45-TWIST1-dependent degradation mechanism., PMID:35802537
Anticancer function of microRNA-30e is mediated by negative regulation of HELLPAR, a noncoding macroRNA, and genes involved in ubiquitination and cell cycle progression in prostate cancer., PMID:35612714
Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation., PMID:35279684
MiR-30a-5p hampers proliferation of lung squamous cell carcinoma through targeting FBXO45., PMID:35098525
Bioinformatics analysis identifying FBXO45 gene as a potential oncogene in esophageal cancer., PMID:35070395
Comprehensive Analysis of Expression, Prognostic Value, and Immune Infiltration for Ubiquitination-Related FBXOs in Pancreatic Ductal Adenocarcinoma., PMID:35046938
Elevated FBXO45 promotes liver tumorigenesis through enhancing IGF2BP1 ubiquitination and subsequent PLK1 upregulation., PMID:34779401
Diagnostic Performance of miR-485-3p in Patients with Parkinson's Disease and its Relationship with Neuroinflammation., PMID:34279788
DNAJB9 suppresses the metastasis of triple-negative breast cancer by promoting FBXO45-mediated degradation of ZEB1., PMID:33966034
IL-24 inhibits the malignancy of human glioblastoma cells via destabilization of Zeb1., PMID:33894112
Systematic analysis of the expression and prognosis relevance of FBXO family reveals the significance of FBXO1 in human breast cancer., PMID:33622332
FBXO45 is a potential therapeutic target for cancer therapy., PMID:32655893
Fbxo45 Binds SPRY Motifs in the Extracellular Domain of N-Cadherin and Regulates Neuron Migration during Brain Development., PMID:32341084
Association Study Reveals One Susceptibility Locus with Vitiligo in the Chinese Han Population., PMID:31644309
FBXO45-MYCBP2 regulates mitotic cell fate by targeting FBXW7 for degradation., PMID:31285543
The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer., PMID:31261900
m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1., PMID:30979372
Palmitoylation enables MAPK-dependent proteostasis of axon survival factors., PMID:30150401
Spinal TNF-α impedes Fbxo45-dependent Munc13-1 ubiquitination to mediate neuropathic allodynia in rats., PMID:30042425
PAM forms an atypical SCF ubiquitin ligase complex that ubiquitinates and degrades NMNAT2., PMID:29997255
Identification of aberrantly expressed F-box proteins in squamous-cell lung carcinoma., PMID:29728763
A genome-wide association study of coping behaviors suggests FBXO45 is associated with emotional expression., PMID:29665250
A Naturally Generated Decoy of the Prostate Apoptosis Response-4 Protein Overcomes Therapy Resistance in Tumors., PMID:28625975
Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis., PMID:28011490
FLASH protects ZEB1 from degradation and supports cancer cells' epithelial-to-mesenchymal transition., PMID:27526108
F-box proteins: Keeping the epithelial-to-mesenchymal transition (EMT) in check., PMID:26506454
The Dual Estrogen Receptor α Inhibitory Effects of the Tissue-Selective Estrogen Complex for Endometrial and Breast Safety., PMID:26487511
Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus., PMID:26068074
For research use only. Not for human or drug use.
