Catalog No.
YHB84701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr11-Lys94
Predicted molecular weight
37.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P00167
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cytochrome b5, Microsomal cytochrome b5 type A, MCB5, CYB5A, CYB5
Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer., PMID:40253525
CYB5A promotes osteogenic differentiation of MC3T3-E1 cells through autophagy mediated by the AKT/mTOR/ULK1 signaling pathway., PMID:40246926
Two families, two pathways: a case series of 46, XY DSD with 17α-hydroxylase deficiency and isolated 17,20-lyase deficiency due to novel CYB5A variant., PMID:40123165
Genetic insights into visceral obesity with health conditions, from disease susceptibility to therapeutic intervention., PMID:39835424
OXPHOS mediators in acute myeloid leukemia patients: Prognostic biomarkers and therapeutic targets for personalized medicine., PMID:39533394
Defects in CYB5A and CYB5B impact sterol-C4 oxidation in cholesterol biosynthesis and demonstrate regulatory roles of dimethyl sterols., PMID:39489939
From bioinformatics to clinical applications: a novel prognostic model of cuproptosis-related genes based on single-cell RNA sequencing data in hepatocellular carcinoma., PMID:39251909
The Multienzyme Complex Nature of Dehydroepiandrosterone Sulfate Biosynthesis., PMID:38396748
Prioritising genetic findings for drug target identification and validation., PMID:38325120
Adrenal steroid metabolites and bone status in patients with adrenal incidentalomas and hypercortisolism., PMID:37543511
Abnormal DNA methylation within genes of the steroidogenesis pathway two years after paediatric critical illness and association with stunted growth in height further in time., PMID:37468957
The association between CYB5A gene rs1790834 polymorphism and clinical improvement after 6 months of leflunomide treatment in women with rheumatoid arthritis., PMID:37289314
Comparative proteomics reveals genetic mechanisms of body weight in Hu sheep and Dorper sheep., PMID:35995385
Regulating Effect of Cytochrome b5 Overexpression on Human Breast Cancer Cells., PMID:35889429
Cytochrome B5 type A alleviates HCC metastasis via regulating STOML2 related autophagy and promoting sensitivity to ruxolitinib., PMID:35851063
An alternative CYB5A transcript is expressed in aneuploid ALL and enriched in relapse., PMID:35436854
Identification and validation of a cigarette smoke-related five-gene signature as a prognostic biomarker in kidney renal clear cell carcinoma., PMID:35140327
Redox-Regulation of α-Globin in Vascular Physiology., PMID:35052663
Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity., PMID:35043601
Morphologic and Molecular Characterization of Adrenals and Adrenal Rest Affected by Congenital Adrenal Hyperplasia., PMID:34616364
Lack of association between CYB5A gene rs1790834 polymorphism and the response to leflunomide in women with rheumatoid arthritis., PMID:34160668
Successful Delivery in 17,20-Lyase Deficiency., PMID:33824988
Isolated 17, 20 Lyase Deficiency Secondary to a Novel CYB5A Variant: Comparison of Steroid Metabolomic Findings with Published Cases Provides Diagnostic Guidelines and Greater Insight into Its Biological Role., PMID:33626548
Tandem Mass Tag-Based Proteomic Analysis of Potential Biomarkers for Hepatocellular Carcinoma Differentiation., PMID:33603407
The Age-Dependent Changes of the Human Adrenal Cortical Zones Are Not Congruent., PMID:33524149
Targeted mRNA demethylation using an engineered dCas13b-ALKBH5 fusion protein., PMID:32356894
Effect of mutations in porcine CYB5A and CYP17A1 on the metabolism of pregnenolone., PMID:31509771
Crystal structures of the naturally fused CS and cytochrome b5 reductase (b5R) domains of Ncb5or reveal an expanded CS fold, extensive CS-b5R interactions and productive binding of the NAD(P)+ nicotinamide ring., PMID:31282472
Label-Free LC-MS/MS Proteomics Analyses Reveal Proteomic Changes Accompanying MSTN KO in C2C12 Cells., PMID:31073529
11-Oxygenated C19 Steroids Do Not Decline With Age in Women., PMID:30753518
Forms of selenium in vitamin-mineral mixes differentially affect the expression of genes responsible for prolactin, ACTH, and α-MSH synthesis and mitochondrial dysfunction in pituitaries of steers grazing endophyte-infected tall fescue., PMID:30476104
SPR-Based study of affinity of cytochrome P450s / redox partners interactions modulated by steroidal substrates., PMID:30468857
[The sequence coverage in different methods of mass spectrometry data analysis obtained on model proteins]., PMID:29080871
Isatin-induced increase in the affinity of human ferrochelatase and adrenodoxin reductase interaction., PMID:28905435
Kinetic processivity of the two-step oxidations of progesterone and pregnenolone to androgens by human cytochrome P450 17A1., PMID:28684414
Efficient Reduction of Vertebrate Cytoglobins by the Cytochrome b5/Cytochrome b5 Reductase/NADH System., PMID:28671819
[The effect of isatin on protein-protein interactions between cytochrome b5 and cytochromes P450]., PMID:28414290
Thermodynamics of interactions between mammalian cytochromes P450 and b5., PMID:28238672
Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate., PMID:27623070
2,3,7,8 Tetrachlorodibenzo-p-dioxin-induced RNA abundance changes identify Ackr3, Col18a1, Cyb5a and Glud1 as candidate mediators of toxicity., PMID:27136898
Combined steroidogenic characters of fetal adrenal and Leydig cells in childhood adrenocortical carcinoma., PMID:26940356
Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic., PMID:26862015
Unraveling the complexity of autophagy: Potential therapeutic applications in Pancreatic Ductal Adenocarcinoma., PMID:26408419
CYB5A polymorphism increases androgens and reduces risk of rheumatoid arthritis in women., PMID:25890314
Genetic variation in CYB5R3 is associated with methemoglobin levels in preterm infants receiving nitric oxide therapy., PMID:25521918
Differential expression of CYB5A in Chinese and European pig breeds due to genetic variations in the promoter region., PMID:25516134
Polymorphisms in the carcinogen detoxification genes CYB5A and CYB5R3 and breast cancer risk in African American women., PMID:25225034
Protein interactomics based on direct molecular fishing on paramagnetic particles: practical realization and further SPR validation., PMID:25044858
3βHSD and CYB5A double positive adrenocortical cells during adrenal development/aging., PMID:24832628
CYB5A and autophagy-mediated cell death in pancreatic cancer., PMID:24448000
For research use only. Not for human or drug use.
