Catalog No.
YHB70801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser423-Ile700
Predicted molecular weight
33.57 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95644
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-ATc, NFATc, NFATC1, NFAT2, NFATC
NFATC2/SERPINE1/JAK3/STAT3 signaling feedback loop in gastric cancer: immune evasion and anti-PD-1 resistance., PMID:40512406
Synergistic Crosstalk of PACAP and Notch Signaling Pathways in Bone Development., PMID:40507899
Soluble β-Amyloid Oligomers Selectively Upregulate TRPC3 in Excitatory Neurons via Calcineurin-Coupled NFAT., PMID:40498020
Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/NFAT3 mechanism., PMID:40495950
Lobetyolin Suppressed Osteoclastogenesis and Alleviated Bone Loss in Ovariectomy-Induced Osteoporosis via Hindering p50/p65 Nuclear Translocation and Downstream NFATc1/c-Fos Expression., PMID:40486125
Therapeutic potential of Triptolide in inhibiting breast cancer-induced bone destruction - PTHrP as a therapeutic target., PMID:40444046
Network pharmacology and in-depth blood proteomics reveal the mechanism of Buqi Tongluo capsules in treating bone destruction in osteoarthritis., PMID:40435578
PIEZO1-mediated calcium signaling reinforces mechanical properties of hair follicle stem cells to promote quiescence., PMID:40435254
Kujigamberol Inhibits IFN-γ and IL-2 mRNA Expression and NFATc2 Binding to Their Promoters in Response to a Phorbol Ester and Ionomycin Stimulation., PMID:40430387
Investigation into the Mechanisms of Paeoniae Radix Rubra in the Treatment of Venous Thrombosis Using Network Pharmacology, Bioinformatics, and Molecular Docking Techniques., PMID:40417754
MafB regulates hair follicle stem cell activation and hair regeneration through NFATc1 signaling pathway., PMID:40414006
Brevilin A, a novel BNIP3 inhibitor suppresses osteoclastogenesis and prevents ovariectomy-induced bone loss via impairing mitophagy and mitochondrial metabolism., PMID:40408943
Piezo1 Is an Early Mediator During Topography-Stimulated Osteogenic Differentiation of Bone Mesenchymal Stem Cells., PMID:40405805
Polysaccharides from Psoralea corylifolia seeds suppress osteoclastogenesis and alleviate osteoporosis., PMID:40403806
Lonicerin targets ADRA1D and RSPO3 to ameliorate diabetes-induced vascular injury through Ca2+/Calcineurin/NFAT1-dependent anti-EndMT pathway., PMID:40398181
Maltol promotes osteoclastogenesis and exacerbates periodontitis via TRAF6/JNK/Nfatc1 pathway., PMID:40373380
Myocyte-Specific Enhancer Factor 2A Potentiates Osteoclastic Differentiation in Osteoporosis by Inducing Endothelin Receptor Type A., PMID:40369222
FABP4 inhibition suppresses bone resorption and protects against postmenopausal osteoporosis in ovariectomized mice., PMID:40360512
PEX5 acts as a negative regulator of RANKL-induced osteoclastogenesis in vitro and inflammatory calvarial bone destruction in vivo., PMID:40319819
Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 Drives Subchondral Bone Damage in Temporomandibular Joint Osteoarthritis through Peroxisome Proliferator-Activated Receptor γ/C-FOS-Regulated Dual Pathways: Nuclear Factor of Activated T Cells 1 Signaling and Autophagy-Related 16-Like 2-Mediated Autophagy., PMID:40316216
Role of TRPM2 in Oxidative Stress-Mediated Bone Loss in Periodontitis., PMID:40312852
Genkwanin blocks the interaction between phosphorylated JNK and NFATc1 to promote osteogenic differentiation and collagen Ⅰ α1 production., PMID:40311832
During high salt treatment myeloid p38α/MAPK fosters osteoclast activity and inflammatory macrophage responses promoting orthodontic tooth movement., PMID:40303394
Roles of Transmembrane Protein 119 in the Effects of Transforming Growth Factor-β on Mouse Bone Cells., PMID:40300647
Orai1 Participates in Coronary Artery Dysfunction Caused by Hypertension via Regulating Smooth Muscle Cell Phenotype Transformation., PMID:40293813
NFAT2 promotes sorafenib resistance in hepatocellular carcinoma cells by modulating calcium ion signalling., PMID:40288600
Chrysin improves endothelial inflammation via the NFAT pathway in Kawasaki disease., PMID:40285837
IL-10 alleviates aTCMR by inhibiting NFATc1 signaling pathway of T cells after kidney transplantation., PMID:40268206
[Research progress on the role of CaN/NFAT signaling pathway activated by Ca2+ overload in hypertensive cardiac hypertrophy]., PMID:40255011
Rhusflavone Modulates Osteoclastogenesis Through RANKL-Induced AKT Signaling in Bone Marrow-Derived Macrophages., PMID:40243668
RO5126766 attenuates osteoarthritis by inhibiting osteoclastogenesis and protecting chondrocytes through mediating the ERK pathway., PMID:40231159
Integrating thermal proteome profiling and virtual screening to reveal the mechanism of Bletilla striata against osteoclast-driven osteoporosis., PMID:40220420
Visualization and Quantification of NFAT1 Translocation in T Cells., PMID:40220223
Identification of anti-resorptive GPCRs by high-content imaging in human osteoclasts., PMID:40215127
ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway., PMID:40197211
Nat10-mediated N4-acetylcytidine modification enhances Nfatc1 translation to exacerbate osteoclastogenesis in postmenopausal osteoporosis., PMID:40193598
Thiotaurine inhibits melanoma progression by enhancing Ca2+ overload-induced cellular apoptosis., PMID:40189970
Targeted Dual Microdroplets for Modulating Osteoclast Differentiation and Function: A Novel Therapeutic Approach to Combat Osteoporosis., PMID:40181685
[Hypericin ameliorates stress-induced depressive-like behaviors in mice by modulating the CN-NFAT calcium signaling pathway in microglia]., PMID:40159965
Effects of low-level laser irradiation on osteoclastogenesis in prostaglandin E2-stimulated macrophages., PMID:40153082
Differential regulation of calcium-NFAT signaling pathway by Akt isoforms: unraveling effector dynamics and exhaustion of cytotoxic T lymphocytes in tumor microenvironment., PMID:40139836
STIM1 in-frame deletion of eight amino acids in a patient with moderate tubular aggregate myopathy/Stormorken syndrome., PMID:40127930
Melatonin-mediated cGAS-STING signal in senescent macrophages promote TNBC chemotherapy resistance and drive the SASP., PMID:40127867
Cardiomyocytic FoxP3 Attenuates Expression of β Isoform of Myosin Heavy Chain During Cardiac Hypertrophy and Effects of Triptolide., PMID:40123330
Inhibition of stromal MAOA leading activation of WNT5A enhance prostate cancer immunotherapy by involving the transition of cancer-associated fibroblasts., PMID:40121032
Dominant interfering CARD11 variants disrupt JNK signaling to promote GATA3 expression in T cells., PMID:40111223
3-Hydroxybutyrate Promotes Myoblast Proliferation and Differentiation through Energy Metabolism and GPR109a-Mediated Ca2+-NFAT Signaling Pathways., PMID:40099866
IRF2BP2 deficiency: An important form of common variable immunodeficiency with inflammation., PMID:40090425
Mechanical stretch promotes the neutrophil recruitment potential of fibroblasts through the Piezo/NFAT1/LIF axis., PMID:40086612
Pharmacologically targeting fatty acid synthase-mediated de novo lipogenesis alleviates osteolytic bone loss by directly inhibiting osteoclastogenesis through suppression of STAT3 palmitoylation and ROS signaling., PMID:40081616
For research use only. Not for human or drug use.
