Catalog No.
YHB63301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Phe542
Predicted molecular weight
62.01 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O95394
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Phosphoacetylglucosamine mutase, PAGM, 5.4.2.3, Acetylglucosamine phosphomutase, N-acetylglucosamine-phosphate mutase, Phosphoglucomutase-3, PGM 3, PGM3, AGM1
Fluorescence melting curve analysis for genotyping of c.1396G > A (rs473267) of phosphoglucomutase-3 gene., PMID:40409221
Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth., PMID:40249802
Direct detection of 3-nitrotyrosine reveals the nitration of proteins in laboratory exposure and ambient aerosols., PMID:40246517
Hyper IgE Syndrome: Bridging the Gap Between Immunodeficiency, Atopy, and Allergic Diseases., PMID:40082265
PGM3 insufficiency: a glycosylation disorder causing a notable T cell defect., PMID:39776909
Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing., PMID:39381601
Effects of L-Leu-L-Leu peptide on growth, proliferation, and apoptosis in broiler intestinal epithelial cells., PMID:38457989
Tumor-Associated and Systemic Autoimmunity in Pre-Clinical Breast Cancer among Post-Menopausal Women., PMID:38002248
Hyper IgE syndrome-related disease treated with dupilumab: A case report., PMID:37720709
The role of glycosylation in clinical allergy and immunology., PMID:37717626
A Systematic Review of Polycyclic Aromatic Hydrocarbon Derivatives: Occurrences, Levels, Biotransformation, Exposure Biomarkers, and Toxicity., PMID:37703436
ERBIN and phosphoglucomutase 3 deficiency., PMID:37369151
Multitranscript analysis reveals an effect of 2-deoxy-d-glucose on gene expression linked to unfolded protein response and integrated stress response in primary human monocytes and monocyte-derived macrophages., PMID:37290716
PGM3 inhibition shows cooperative effects with erastin inducing pancreatic cancer cell death via activation of the unfolded protein response., PMID:37260977
Multi-Omics Profiling in PGM3 and STAT3 Deficiencies: A Tale of Two Patients., PMID:36768728
Proteomics and bioinformatics analysis of cardiovascular related proteins in offspring exposed to gestational diabetes mellitus., PMID:36277748
Severe Protein Loss in a 6-month-old Exclusively Breastfed Infant with Atopic Dermatitis., PMID:36254543
A novel variant in GNPNAT1 gene causing a spondylo-epi-metaphyseal dysplasia resembling PGM3-Desbuquois like dysplasia., PMID:36097642
RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection., PMID:35883652
PGM3 regulates beta-catenin activity to promote colorectal cancer cell progression., PMID:35723049
A De Novo Cause of PGM3 Deficiency Treated with Hematopoietic Stem Cell Transplantation., PMID:35040011
Targeting PGM3 as a Novel Therapeutic Strategy in KRAS/LKB1 Co-Mutant Lung Cancer., PMID:35011738
Profound differences in IgE and IgG recognition of micro-arrayed allergens in hyper-IgE syndromes., PMID:34653276
Skeletal and Bone Mineral Density Features, Genetic Profile in Congenital Disorders of Glycosylation: Review., PMID:34441372
Inborn errors of IL-6 family cytokine responses., PMID:34044328
Promyelocytic Leukemia Antigen Expression: a Histological Marker for Primary Biliary Cholangitis Diagnosis?, PMID:33850801
Dust exposure and pulmonary inflammation in Standardbred racehorses fed dry hay or haylage: A pilot study., PMID:33840486
Two Novel Homozygous Mutations in Phosphoglucomutase 3 Leading to Severe Combined Immunodeficiency, Skeletal Dysplasia, and Malformations., PMID:33534079
Heterozygous PGM3 Variants Are Associated With Idiopathic Focal Epilepsy With Incomplete Penetrance., PMID:33193641
Novel PGM3 compound heterozygous variants with IgE-related dermatitis, lymphopenia, without syndromic features., PMID:33098103
The Child with Elevated IgE and Infection Susceptibility., PMID:32830295
Hexosamine pathway inhibition overcomes pancreatic cancer resistance to gemcitabine through unfolded protein response and EGFR-Akt pathway modulation., PMID:32235891
Compound Heterozygous PGM3 Mutations in a Thai Patient with a Specific Antibody Deficiency Requiring Monthly IVIG Infusions., PMID:31707513
Clinical Utility Gene Card for: PGM3 defective congenital disorder of glycosylation., PMID:31231132
CDG and immune response: From bedside to bench and back., PMID:31095764
Detection of 3-Nitrotyrosine in Atmospheric Environments via a High-performance Liquid Chromatography-electrochemical Detector System., PMID:30774123
Defective glycosylation leads to defective gp130-dependent STAT3 signaling in PGM3-deficient patients., PMID:30578875
The clinical and mechanistic intersection of primary atopic disorders and inborn errors of growth and metabolism., PMID:30565252
An Update on Syndromes with a Hyper-IgE Phenotype., PMID:30466772
Hyper IgE syndromes: clinical and molecular characteristics., PMID:30264496
Eleven percent intact PGM3 in a severely immunodeficient patient with a novel splice-site mutation, a case report., PMID:30157810
Human hyper-IgE syndrome: singular or plural?, PMID:30094507
Hyper-IgE in the allergy clinic--when is it primary immunodeficiency?, PMID:30043993
Multiplexed detection of DOCK8, PGM3 and STAT3 proteins for the diagnosis of Hyper-Immunoglobulin E syndrome using gold nanoparticles-based immunosensor array platform., PMID:30005381
The effect of geographical and climatic properties on grass pollen and Phl p 5 allergen release., PMID:29626255
Inhibition of the Hexosamine Biosynthetic Pathway by targeting PGM3 causes breast cancer growth arrest and apoptosis., PMID:29515119
Sequence-structure relationships, expression profiles, and disease-associated mutations in the paralogs of phosphoglucomutase 1., PMID:28837627
A founder mutation underlies a severe form of phosphoglutamase 3 (PGM3) deficiency in Tunisian patients., PMID:28704707
A Novel PGM3 Mutation Is Associated With a Severe Phenotype of Bone Marrow Failure, Severe Combined Immunodeficiency, Skeletal Dysplasia, and Congenital Malformations., PMID:28543917
For research use only. Not for human or drug use.
