Catalog No.
YHB49601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met16-Asp338
Predicted molecular weight
39.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94953
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lysine-specific demethylase 4B, 1.14.11.66, JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B, [histone H3]-trimethyl-L-lysine(9) demethylase 4B, KDM4B, JHDM3B, JMJD2B, KIAA0876
Role and regulatory mechanism of DLX5 in rhabdomyosarcoma tumorigenesis., PMID:40258575
FBXO22 deficiency defines a pleiotropic syndrome of growth restriction and multi-system anomalies associated with a unique epigenetic signature., PMID:40215970
KDM4B modulates autocrine IL6 in erythroblasts to prevent ineffective erythropoiesis., PMID:40074853
Ribosomal S6 kinase (RSK) plays a critical role in DNA damage response via the phosphorylation of histone lysine demethylase KDM4B., PMID:39434131
H3K9me3 demethylation by JMJD2B is regulated by pirfenidone resulting in improved NASH., PMID:39433954
Fumarate Restrains Alveolar Bone Restoration via Regulating H3K9 Methylation., PMID:39394783
KDM4B Histone Demethylase Inhibition Attenuates Tumorigenicity of Malignant Melanoma Cells by Overriding the p53-Mediated Tumor Suppressor Pathway., PMID:39358852
Super-enhancer-driven LncRNA PPARα-seRNA exacerbates glucolipid metabolism and diabetic cardiomyopathy via recruiting KDM4B., PMID:38950776
KDM4B mutations in human cancers., PMID:38878505
Deubiquitinase UCHL1 stabilizes KDM4B to augment VEGF signaling and confer bevacizumab resistance in clear cell renal cell carcinoma., PMID:38743986
[The Regulatory Effect of RNA m6 A Methylation Modification on KDM4B Gene Expression in t (8;21) AML Cells by MeRIP-qPCR]., PMID:38660840
Targeting KDM4 family epigenetically triggers antitumour immunity via enhancing tumour-intrinsic innate sensing and immunogenicity., PMID:38390756
The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer., PMID:38317241
Genotype-phenotype correlation study of structural abnormalities in a fetal brain caused by a novel KDM4B variant., PMID:38270710
Methylation of the JMJD2B epigenetic regulator differentially affects its ability to coactivate the ETV1 and JUN transcription factors., PMID:38213775
Genome-Wide Association Studies of 3 Distinct Recovery Phenotypes in Mild Ischemic Stroke., PMID:38181310
Histone demethylase KDM4B accelerates the progression of glioblastoma via the epigenetic regulation of MYC stability., PMID:38093312
KDM4B: A promising oncology therapeutic target., PMID:37923555
Differential second messenger signaling via dopamine neurons bidirectionally regulates memory retention., PMID:37639608
Human phenotype caused by biallelic KDM4B frameshift variant., PMID:37526414
Overcoming the H4K20me3 epigenetic barrier improves somatic cell nuclear transfer reprogramming efficiency in mice., PMID:37322828
Epigenetic Histone Methylation of PPARγ and CPT1A Signaling Contributes to Betahistine Preventing Olanzapine-Induced Dyslipidemia., PMID:37298094
KDM4B down-regulation facilitated breast cancer cell stemness via PHGDH upregulation in H3K36me3-dependent manner., PMID:37249813
Echinomycin as a promising therapeutic agent against KSHV-related malignancies., PMID:37143124
HIF1α-mediated transactivation of WTAP promotes AML cell proliferation via m6A-dependent stabilization of KDM4B mRNA., PMID:37087529
Multi-CpG linear regression models to accurately predict paclitaxel and docetaxel activity in cancer cell lines., PMID:36990534
Histone demethylase KDM4B contributes to advanced clear cell renal carcinoma and association with copy number variations and cell cycle progression., PMID:36952476
Proteome-Wide Analysis Reveals TFEB Targets for Establishment of a Prognostic Signature to Predict Clinical Outcomes of Colorectal Cancer., PMID:36765702
Changes in N6-methyladenosine RNA methylomes of human periodontal ligament cells in response to inflammatory conditions., PMID:36733232
[Effect of Morus alba extract sanggenon C on growth and proliferation of glioblastoma cells]., PMID:36725273
Therapeutic targeting of histone lysine demethylase KDM4B blocks the growth of castration-resistant prostate cancer., PMID:36495660
Mapping brain gene coexpression in daytime transcriptomes unveils diurnal molecular networks and deciphers perturbation gene signatures., PMID:36265442
Histone H3K9 demethylase JMJD2B/KDM4B promotes osteogenic differentiation of bone marrow-derived mesenchymal stem cells by regulating H3K9me2 on RUNX2., PMID:36217382
Intermittent hypoxia enhances the expression of hypoxia inducible factor HIF1A through histone demethylation., PMID:36174675
Epigenetic regulation of Cebpb activation by pY19-Caveolin-2 at the nuclear periphery in association with the nuclear lamina., PMID:36165916
New Transmission-Selective Antimalarial Agents through Hit-to-Lead Optimization of 2-([1,1'-Biphenyl]-4-carboxamido)benzoic Acid Derivatives., PMID:36106425
JmjC Family of Histone Demethylases Form Nuclear Condensates., PMID:35887017
JIB-04, a Pan-Inhibitor of Histone Demethylases, Targets Histone-Lysine-Demethylase-Dependent AKT Pathway, Leading to Cell Cycle Arrest and Inhibition of Cancer Stem-Like Cell Properties in Hepatocellular Carcinoma Cells., PMID:35887001
Targeting KDM4 for treating PAX3-FOXO1-driven alveolar rhabdomyosarcoma., PMID:35857643
Epigenetic Regulation of NGF-Mediated Osteogenic Differentiation in Human Dental Mesenchymal Stem Cells., PMID:35728620
Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer., PMID:35534851
Loss of KDM4B impairs osteogenic differentiation of OMSCs and promotes oral bone aging., PMID:35525910
KDM4B, a potential prognostic biomarker revealed by large-scale public databases and clinical samples in uterine corpus endometrial carcinoma., PMID:35485290
Histone H3.3 phosphorylation promotes heterochromatin formation by inhibiting H3K9/K36 histone demethylase., PMID:35451487
The Diverse Roles of Histone Demethylase KDM4B in Normal and Cancer Development and Progression., PMID:35186950
CircKDM4B suppresses breast cancer progression via the miR-675/NEDD4L axis., PMID:35145234
A protocol for high-throughput screening of histone lysine demethylase 4 inhibitors using TR-FRET assay., PMID:34485934
Effects of demethylase KDM4B on the biological characteristics and function of yak cumulus cells in vitro., PMID:34425304
Detection of fusion gene transcripts in the blood samples of prostate cancer patients., PMID:34417538
LncRNA AERRIE Is Required for Sulfatase 1 Expression, but Not for Endothelial-to-Mesenchymal Transition., PMID:34360851
For research use only. Not for human or drug use.
