Catalog No.
YHB42601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp11-Thr218
Predicted molecular weight
25.26 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O94762
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATP-dependent DNA helicase Q5, 5.6.2.4, DNA 3'-5' helicase RecQ5, DNA helicase, RecQ-like type 5, RecQ5, RecQ protein-like 5, RECQL5, RECQ5
Serum-Based Proteomic Approach to Identify Clinical Biomarkers of Radiation Exposure., PMID:40149344
Search for germline gene variants in colorectal cancer families presenting with multiple primary colorectal cancers., PMID:39654522
Senataxin and DNA-PKcs Redundantly Promote Non-Homologous End Joining Repair of DNA Double Strand Breaks During V(D)J Recombination., PMID:39386666
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication., PMID:39284827
RecQ helicase expression in patients with telomeropathies., PMID:38874681
Expression of human RECQL5 in Saccharomyces cerevisiae causes transcription defects and transcription-associated genome instability., PMID:38796829
A Recql5 mutant facilitates complex CRISPR/Cas9-mediated chromosomal engineering in mouse zygotes., PMID:38577877
RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication., PMID:38530355
BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution., PMID:38266639
USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication., PMID:38260523
Fascin actin-bundling protein 1 regulates non-small cell lung cancer progression by influencing the transcription and splicing of tumorigenesis-related genes., PMID:38077434
Gene polymorphisms associated with sudden decreases in heart rate during extensive peritoneal lavage with distilled water after gastrectomy., PMID:37969699
Functional inhibition of RECQL5 helicase elicits non-homologous end joining response and sensitivity of breast cancers to PARP inhibitor., PMID:37392863
RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice., PMID:36948261
Chemical Composition, In Silico and In Vitro Antimutagenic Activities of Ethanolic and Aqueous Extracts of Tigernut (Cyperus esculentus)., PMID:35919571
RecQ Helicase Somatic Alterations in Cancer., PMID:35782872
The deubiquitinase USP28 stabilizes the expression of RecQ family helicases and maintains the viability of triple negative breast cancer cells., PMID:34822842
Human RecQL4 as a Novel Molecular Target for Cancer Therapy., PMID:34474412
Human RecQ Helicases in DNA Double-Strand Break Repair., PMID:33718381
Human RecQ helicases in transcription-associated stress management: bridging the gap between DNA and RNA metabolism., PMID:33567180
Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitro and in Vivo., PMID:33529023
Single-molecule visualization of human RECQ5 interactions with single-stranded DNA recombination intermediates., PMID:33332547
Human RECQL5 promotes metastasis and resistance to cisplatin in non-small cell lung cancer., PMID:33217443
RECQL5 KIX domain splicing isoforms have distinct functions in transcription repression and DNA damage response., PMID:33197722
The Genetic and Physical Interactomes of the Saccharomyces cerevisiae Hrq1 Helicase., PMID:33115721
TRIM28 functions as the SUMO E3 ligase for PCNA in prevention of transcription induced DNA breaks., PMID:32900933
RECQL5 at the Intersection of Replication and Transcription., PMID:32523948
Mining the role of RECQL5 in gastric cancer and seeking potential regulatory network by bioinformatics analysis., PMID:32497619
Role of DNA Damage Response in Suppressing Malignant Progression of Chronic Myeloid Leukemia and Polycythemia Vera: Impact of Different Oncogenes., PMID:32272770
Low expression of RecQ-like helicase 5 is associated with poor prognosis in patients with gastric cancer., PMID:31897211
Functional conservation of RecQ helicase BLM between humans and Drosophila melanogaster., PMID:31772289
Fork Cleavage-Religation Cycle and Active Transcription Mediate Replication Restart after Fork Stalling at Co-transcriptional R-Loops., PMID:31759821
RECQL5 plays an essential role in maintaining genome stability and viability of triple-negative breast cancer cells., PMID:31231988
RECQL5: Another DNA helicase potentially involved in hereditary breast cancer susceptibility., PMID:30817846
Distinct prognosis of mRNA expression of the five RecQ DNA-helicase family members - RECQL, BLM, WRN, RECQL4, and RECQL5 - in patients with breast cancer., PMID:30584360
Long Non-Coding RNA Urothelial Carcinoma Associated 1 Promotes Proliferation, Migration and Invasion of Osteosarcoma Cells by Regulating microRNA-182., PMID:30481751
Increased levels of RECQ5 shift DNA repair from canonical to alternative pathways., PMID:30107528
SUMO2 conjugation of PCNA facilitates chromatin remodeling to resolve transcription-replication conflicts., PMID:30006506
Germline pathogenic variants in PALB2 and other cancer-predisposing genes in families with hereditary diffuse gastric cancer without CDH1 mutation: a whole-exome sequencing study., PMID:29706558
[Preparation, characterization and application of monoclonal antibody against RecQ helicase]., PMID:29673459
The roles of JAK2 in DNA damage and repair in the myeloproliferative neoplasms: Opportunities for targeted therapy., PMID:29627078
Molecular-genetic profiling and high-throughput in vitro drug screening in NUT midline carcinoma-an aggressive and fatal disease., PMID:29348827
KIXBASE: A comprehensive web resource for identification and exploration of KIX domains., PMID:29097748
RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis., PMID:28575661
Clinical Impact of Tumor DNA Repair Expression and T-cell Infiltration in Breast Cancers., PMID:28254786
RECQL5 plays co-operative and complementary roles with WRN syndrome helicase., PMID:28180303
Insights into the RecQ helicase mechanism revealed by the structure of the helicase domain of human RECQL5., PMID:28100692
Altered RECQL5 expression in urothelial bladder carcinoma increases cellular proliferation and makes RECQL5 helicase activity a novel target for chemotherapy., PMID:27764811
RECQ5 helicase promotes resolution of conflicts between replication and transcription in human cells., PMID:27502483
A Comparative Study of G-Quadruplex Unfolding and DNA Reeling Activities of Human RECQ5 Helicase., PMID:27332117
For research use only. Not for human or drug use.
