Catalog No.
YHB34501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser57-Lys467
Predicted molecular weight
48.93 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75899
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Gamma-aminobutyric acid type B receptor subunit 2, GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2, G-protein coupled receptor 51, HG20, GABBR2, GPR51, GPRC3B
TAp73α drives cancer metastasis via PPI-mediated derepression of the neuronal HDAC2/REST-GABBR2 axis., PMID:40505831
Huntingtin-Interacting Protein 1-Related (HIP1R) Regulates Rheumatoid Arthritis Synovial Fibroblast Invasiveness., PMID:40214437
Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Igfbp7 to sustain ILC3 homeostasis., PMID:40033120
Identification of KCNJ5 gene an adverse prognosis associated novel onco-ionchannel in Indian pancreatic cancer cohort., PMID:39998707
Time dependent changes in protein expression induced by intermittent theta burst stimulation in a cell line., PMID:39529622
Multi-Omics Approach Reveals Genes and Pathways Affected in Miller-Dieker Syndrome., PMID:39508990
Jejunal transcriptomic profiling of carnosine synthesis precursor-related genes and pathways in slow-growing Korat chicken., PMID:39033572
Presynaptic hyperexcitability reversed by positive allosteric modulation of a GABABR epilepsy variant., PMID:39028675
Paeonol and glycyrrhizic acid in combination ameliorate the recurrent nitroglycerin-induced migraine-like phenotype in rats by regulating the GABBR2/TRPM8/PRKACA/TRPV1 pathway., PMID:38908492
Impact of Abl2/Arg deficiency on anxiety and depressive behaviors in mice., PMID:38697301
Coordination among frequent genetic variants imparts substance use susceptibility and pathogenesis., PMID:38660223
Ligand-gated ion channels as potential biomarkers for ADT-mediated cognitive decline in prostate cancer patients., PMID:38482990
Identification of genes regulated by trait sensitivity to negative feedback and prolonged alcohol consumption in rats., PMID:38172401
Paeonol ameliorates hippocampal neuronal damage by inhibiting GRM5/GABBR2/β-arrestin2 and activating the cAMP-PKA signaling pathway in premenstrual irritability rats., PMID:38036272
GABBR2 as a Downstream Effector of the Androgen Receptor Induces Cisplatin Resistance in Bladder Cancer., PMID:37762034
HSV-1 latency-associated transcript miR-H3 and miR-H4 target STXBP1 and GABBR2 genes., PMID:37668872
γ-aminobutyric acid B2 receptor: A potential therapeutic target for cholangiocarcinoma in patients with diabetes mellitus., PMID:37576707
Machine Learning Selection of Most Predictive Brain Proteins Suggests Role of Sugar Metabolism in Alzheimer's Disease., PMID:36776048
GABBR1 monoallelic de novo variants linked to neurodevelopmental delay and epilepsy., PMID:36103875
Nongenetic and genetic predictors of haemodynamic instability induced by propofol and opioids: A retrospective clinical study., PMID:35939394
Genetic variations in GABA metabolism and epilepsy., PMID:35850019
Paroxysmal limb dystonias associated with GABBR2 pathogenic variant: A case-based literature review., PMID:35414446
Rare variants in IFFO1, DTNB, NLRC3 and SLC22A10 associate with Alzheimer's disease CSF profile of neuronal injury and inflammation., PMID:35173266
Comparative analysis of protein-protein interaction networks in metastatic breast cancer., PMID:35045088
A preliminary genetic association study of GAD1 and GABAB receptor genes in patients with treatment-resistant schizophrenia., PMID:34845648
Identification of Potential Core Genes in Parkinson's Disease Using Bioinformatics Analysis., PMID:34580608
Molecular description of meningeal solitary fibrous tumors/hemangiopericytomas compared to meningiomas: two completely separate entities., PMID:34417711
Dystonia as a prominent presenting feature in developmental and epileptic encephalopathies: A case series., PMID:34399161
A Multi-center Genome-wide Association Study of Cervical Dystonia., PMID:34320236
G Protein-coupled Receptors in Radioiodine-refractory Thyroid Cancer in the Era of Precision Medicine., PMID:34000025
Anti-spastic effect induced by waggle needling correlates with KCC2-GABAA pathway in post-stroke spasticity rats., PMID:33705929
Genetic inactivation of the sigma-1 chaperone protein results in decreased expression of the R2 subunit of the GABA-B receptor and increased susceptibility to seizures., PMID:33385516
Genetic diagnosis of infantile-onset epilepsy in the clinic: Application of whole-exome sequencing following epilepsy gene panel testing., PMID:33349918
Structural Basis for Activation of the Heterodimeric GABAB Receptor., PMID:33058878
Screening and Identification of Key Biomarkers in Melanoma: Evidence from Bioinformatic Analyses., PMID:32985909
Clustering by phenotype and genome-wide association study in autism., PMID:32807774
Regulated expression and function of the GABAB receptor in human pancreatic beta cell line and islets., PMID:32778664
ceRNA network development and tumour-infiltrating immune cell analysis of metastatic breast cancer to bone., PMID:32760644
Brain transcriptome study through CRISPR/Cas9 mediated mouse Dip2c gene knock-out., PMID:32707302
MicroRNA-330 Directs Downregulation of the GABABR2 in the Pathogenesis of Pancreatic Cancer Pain., PMID:32621101
Identification of Differentially Expressed Genes Associated with Papillary Thyroid Carcinoma., PMID:32238134
BDNF deficiency and enriched environment treatment affect neurotransmitter gene expression differently across ages., PMID:32222968
Reelin signaling modulates GABAB receptor function in the neocortex., PMID:32083308
Age-related Effects of Heroin on Gene Expression in the Hippocampus and Striatum of Cynomolgus Monkeys., PMID:31958910
Maternal Intake of n-3 Polyunsaturated Fatty Acids During Pregnancy Is Associated With Differential Methylation Profiles in Cord Blood White Cells., PMID:31708974
USP8 mutations in corticotroph adenomas determine a distinct gene expression profile irrespective of functional tumour status., PMID:31581124
GWAS of five gynecologic diseases and cross-trait analysis in Japanese., PMID:31488892
Lithium and GADL1 regulate glycogen synthase kinase-3 activity to modulate KCTD12 expression., PMID:31311980
Vigabatrin as a Targeted Treatment of GABAB Receptor-Related Epileptic Encephalopathy., PMID:31122837
Physiological Expression of Ion Channel Receptors in Human Periodontal Ligament Stem Cells., PMID:30845727
For research use only. Not for human or drug use.
