Catalog No.
YHB30802
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln140
Predicted molecular weight
18.47 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75791
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GRB2-related adapter protein 2, Adapter protein GRID, GRB-2-like protein, GRB2L, GRBLG, GRBX, Grf40 adapter protein, Grf-40, Growth factor receptor-binding protein, Hematopoietic cell-associated adapter protein GrpL, P38, Protein GADS, SH3-SH2-SH3 adapter Mona, GRAP2, GADS, GRB2L, GRID
GCIP and SIRT6 cooperatively suppress ITGAV gene expression by modulating c-myc transcription ability., PMID:39955062
Value of altered methylation patterns of genes RANBP3, LCP2 and GRAP2 in cfDNA in breast cancer diagnosis., PMID:39139156
Anti-inflammatory potential of delta-9-tetrahydrocannabinol in hyperinsulinemia: an experimental study., PMID:36239881
GRAP2 is a prognostic biomarker and correlated with immune infiltration in lung adenocarcinoma., PMID:36181310
Involvement of MicroRNA-27a-3p in the Licorice-Induced Alteration of Cd28 Expression in Mice., PMID:35885926
Identification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas., PMID:34790823
Genome-Wide Association Study of Growth Performance and Immune Response to Newcastle Disease Virus of Indigenous Chicken in Rwanda., PMID:34745207
Itk Promotes the Integration of TCR and CD28 Costimulation through Its Direct Substrates SLP-76 and Gads., PMID:33931484
Identification of Hub Genes and Pathways of Triple Negative Breast Cancer by Expression Profiles Analysis., PMID:33688252
Grap2 cyclin D interacting protein negatively regulates CREB‑binding protein, inhibiting fibroblast‑like synoviocyte growth., PMID:33576455
T-cell receptors provide potential prognostic signatures for breast cancer., PMID:33527533
Identification of prognosis-related genes in the cervical cancer immune microenvironment., PMID:32946928
MEK2 is a critical modulating mechanism to down-regulate GCIP stability and function in cancer cells., PMID:31907980
Bridging the Gap: Modulatory Roles of the Grb2-Family Adaptor, Gads, in Cellular and Allergic Immune Responses., PMID:31402911
Cooperative assembly of a four-molecule signaling complex formed upon T cell antigen receptor activation., PMID:30510001
Expression of T-cell receptor signalling pathway components in extranodal NK/T-cell lymphoma., PMID:30102799
T Cell Costimulation by CD6 Is Dependent on Bivalent Binding of a GADS/SLP-76 Complex., PMID:28289074
Evidence for genetic regulation of the human parieto-occipital 10-Hz rhythmic activity., PMID:27306141
Validation of an oligo-gene signature for the prognostic stratification of ductal carcinoma in situ (DCIS)., PMID:27250000
Expression of GADS enhances FLT3-induced mitogenic signaling., PMID:26895103
Recurrent activating mutations of CD28 in peripheral T-cell lymphomas., PMID:26719098
The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells., PMID:26214742
miR-9 Modulates Osteosarcoma Cell Growth by Targeting the GCIP Tumor Suppressor., PMID:26107195
A peptide-functionalized polymer as a minimal scaffold protein to enhance cluster formation in early T cell signal transduction., PMID:25663649
GADS is required for TCR-mediated calcium influx and cytokine release, but not cellular adhesion, in human T cells., PMID:25636200
Modulation of TCR responsiveness by the Grb2-family adaptor, Gads., PMID:25452106
Intracellular TCR-signaling pathway: novel markers for lymphoma diagnosis and potential therapeutic targets., PMID:25118816
GCIP functions as a tumor suppressor in non-small cell lung cancer by suppressing Id1-mediated tumor promotion., PMID:24970809
Quantitative analysis by surface plasmon resonance of CD28 interaction with cytoplasmic adaptor molecules Grb2, Gads and p85 PI3K., PMID:24475931
Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia., PMID:23399893
RT-qPCR study on post-mortem brain samples from patients with major psychiatric disorders: reference genes and specimen characteristics., PMID:21704324
The phenotype of recurrent 10q22q23 deletions and duplications., PMID:21248748
Histidine domain-protein tyrosine phosphatase interacts with Grb2 and GrpL., PMID:21179510
Varying expression of four genes sharing a common regulatory sequence may differentiate rheumatoid arthritis from ageing effects on the CD4(+) lymphocytes., PMID:20738421
SH2 domain containing leukocyte phosphoprotein of 76-kDa (SLP-76) feedback regulation of ZAP-70 microclustering., PMID:20534575
Dynamics of subsynaptic vesicles and surface microclusters at the immunological synapse., PMID:20460647
T cell activation at the immunological synapse: vesicles emerge for LATer signaling., PMID:20460646
A novel senescence-evasion mechanism involving Grap2 and Cyclin D interacting protein inactivation by Ras associated with diabetes in cancer cells under doxorubicin treatment., PMID:20460530
Generating a panel of highly specific antibodies to 20 human SH2 domains by phage display., PMID:20164216
The Bcr-Abl kinase regulates the actin cytoskeleton via a GADS/Slp-76/Nck1 adaptor protein pathway., PMID:20079431
Expression of the Grb2-related RET adapter protein Grap-2 in human medullary thyroid carcinoma., PMID:19027225
Immunohistochemical expression of GCIP in breast carcinoma: relationship with tumour grade, disease-free survival, mucinous differentiation and response to chemotherapy., PMID:18983464
Expression of aquaporin 5 (AQP5) promotes tumor invasion in human non small cell lung cancer., PMID:18478076
CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription., PMID:18295596
Structural features of the full-length adaptor protein GADS in solution determined using small-angle X-ray scattering., PMID:17993503
Ribosomal phosphoprotein P0 interacts with GCIP and overexpression of P0 is associated with cellular proliferation in breast and liver carcinoma cells., PMID:17621266
Human GCIP interacts with CT847, a novel Chlamydia trachomatis type III secretion substrate, and is degraded in a tissue-culture infection model., PMID:17532760
A case-control association study between the GRID1 gene and schizophrenia in the Chinese Northern Han population., PMID:17490860
Efficient T-cell receptor signaling requires a high-affinity interaction between the Gads C-SH3 domain and the SLP-76 RxxK motif., PMID:17235283
Crystal structure of the C-terminal SH3 domain of the adaptor protein GADS in complex with SLP-76 motif peptide reveals a unique SH3-SH3 interaction., PMID:17010654
For research use only. Not for human or drug use.
