Catalog No.
YHB29801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly11-Gln311
Predicted molecular weight
36.56 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75746
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial, Araceli hiperlarga, Aralar, Aralar1, Mitochondrial aspartate glutamate carrier 1, Solute carrier family 25 member 12, SLC25A12, AGC1, ARALAR1
Alteration in Ca2+ signaling-related genes in schizophrenia., PMID:40388041
Genetic aetiologies in relation to response to the ketogenic diet in 226 children with epilepsy., PMID:40290421
OXPHOS mediators in acute myeloid leukemia patients: Prognostic biomarkers and therapeutic targets for personalized medicine., PMID:39533394
Calcium signaling in mitochondrial intermembrane space., PMID:39392359
SLC25A12 inhibits Japanese encephalitis virus replication by interacting with the NS1 and enhancing the type I interferon response., PMID:39096789
[Analysis of a child with developmental disorder and epilepsy due to a homozygous variant of SLC25A12 gene]., PMID:38946367
The mitochondrial aspartate/glutamate carrier does not transport GABA., PMID:38945283
AspSnFR: A genetically encoded biosensor for real-time monitoring of aspartate in live cells., PMID:38806058
Transcriptional and metabolic effects of aspartate-glutamate carrier isoform 1 (AGC1) downregulation in mouse oligodendrocyte precursor cells (OPCs)., PMID:38553684
Expression assay of calcium signaling related lncRNAs in autism., PMID:38265729
Capsaicin inhibits A7r5 cell senescence via the mitochondrial carrier protein Slc25a12., PMID:37995921
A pilot study on glutamate receptor and carrier gene variants and risk of childhood autism spectrum., PMID:37578654
Ketogenic Diet Treatment of Defects in the Mitochondrial Malate Aspartate Shuttle and Pyruvate Carrier., PMID:36079864
TIMM13 as a prognostic biomarker and associated with immune infiltration in skin cutaneous melanoma (SKCM)., PMID:36061054
SLC25A12 Missense Variant in Nova Scotia Duck Tolling Retrievers Affected by Cerebellar Degeneration-Myositis Complex (CDMC)., PMID:35886006
Pathogenic variants of the mitochondrial aspartate/glutamate carrier causing citrin deficiency., PMID:35725541
Genetics of autism spectrum disorder: an umbrella review of systematic reviews and meta-analyses., PMID:35705542
AGC1 Deficiency: Pathology and Molecular and Cellular Mechanisms of the Disease., PMID:35008954
SLC gene mutations and pediatric neurological disorders: diverse clinical phenotypes in a Saudi Arabian population., PMID:34797406
Citrin deficiency: Does the reactivation of liver aralar-1 come into play and promote HCC development?, PMID:34228977
Genetic risk factors for autism-spectrum disorders: a systematic review based on systematic reviews and meta-analysis., PMID:34115189
Transcriptome analysis of embryonic muscle development in Chengkou Mountain Chicken., PMID:34107874
Protein Biomarkers of Autism Spectrum Disorder Identified by Computational and Experimental Methods., PMID:33716802
Phosphoproteomics of the developing heart identifies PERM1 - An outer mitochondrial membrane protein., PMID:33549681
βOHB Protective Pathways in Aralar-KO Neurons and Brain: An Alternative to Ketogenic Diet., PMID:33087477
A Novel Nonsense Gene Variant Responsible for Early Infantile Epileptic Encephalopathy Type 39: Case Report., PMID:32700846
[Prognostic Value of SLC25A12 Expression in Patients with Acute Myeloid Leukemia Based on Integrated Analysis of Multi-dimensional Clinical Data]., PMID:32319366
Aralar Sequesters GABA into Hyperactive Mitochondria, Causing Social Behavior Deficits., PMID:32200800
The microRNAs miR-302b and miR-372 regulate mitochondrial metabolism via the SLC25A12 transporter, which controls MAVS-mediated antiviral innate immunity., PMID:31767682
Expanding Phenotypic Spectrum of Cerebral Aspartate-Glutamate Carrier Isoform 1 (AGC1) Deficiency., PMID:31766059
A Mutation in the Mitochondrial Aspartate/Glutamate Carrier Leads to a More Oxidizing Intramitochondrial Environment and an Inflammatory Myopathy in Dutch Shepherd Dogs., PMID:31594244
Maintaining cytosolic aspartate levels is a major function of the TCA cycle in proliferating cells., PMID:31528687
Deficiency of Mitochondrial Aspartate-Glutamate Carrier 1 Leads to Oligodendrocyte Precursor Cell Proliferation Defects Both In Vitro and In Vivo., PMID:31514314
Mitochondrial movement in Aralar/Slc25a12/AGC1 deficient cortical neurons., PMID:31472174
Longitudinal MRI findings in patient with SLC25A12 pathogenic variants inform disease progression and classification., PMID:31403263
Epigenetic upregulation and functional role of the mitochondrial aspartate/glutamate carrier isoform 1 in hepatocellular carcinoma., PMID:30321589
Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting., PMID:30122555
Effects of fish and krill oil on gene expression in peripheral blood mononuclear cells and circulating markers of inflammation: a randomised controlled trial., PMID:29599972
Single Nucleotide Polymorphisms in SLC19A1 and SLC25A9 Are Associated with Childhood Autism Spectrum Disorder in the Chinese Han Population., PMID:28536923
Deficient glucose and glutamine metabolism in Aralar/AGC1/Slc25a12 knockout mice contributes to altered visual function., PMID:27746674
Uncoupling Protein 2 (UCP2) Function in the Brain as Revealed by the Cerebral Metabolism of (1-13C)-Glucose., PMID:27401256
AGC1/2, the mitochondrial aspartate-glutamate carriers., PMID:27132995
L-Lactate-Mediated Neuroprotection against Glutamate-Induced Excitotoxicity Requires ARALAR/AGC1., PMID:27098689
Glutamate excitotoxicity and Ca2+-regulation of respiration: Role of the Ca2+ activated mitochondrial transporters (CaMCs)., PMID:27060251
Calcium regulation of mitochondrial carriers., PMID:27033520
Proteomic analysis for the impact of hypercholesterolemia on expressions of hepatic drug transporters and metabolizing enzymes., PMID:26887802
In Vivo Detection of Mitochondrial Dysfunction Induced by Clinical Drugs and Disease-Associated Genes Using a Novel Dye ZMJ214 in Zebrafish., PMID:26630578
Asymmetric dimethylarginine is transported by the mitochondrial carrier SLC25A2., PMID:26403849
Association between genetic variants in SLC25A12 and risk of autism spectrum disorders: An integrated meta-analysis., PMID:25921325
Role of AGC1/aralar in the metabolic synergies between neuron and glia., PMID:25889949
For research use only. Not for human or drug use.
