Catalog No.
YHB28601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Asn371
Predicted molecular weight
43.20 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75688
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein phosphatase 1B, 3.1.3.16, Protein phosphatase 2C isoform beta, PP2C-beta, PPM1B, PP2CB
Targeted plasma proteomics reveals organ damage signatures of AIDS- and noncommunicable disease-related deaths in people with HIV., PMID:40274826
PPM1B degradation mediated by TRIM25 ubiquitination modulates cell cycle and promotes gastric cancer growth., PMID:39979355
BRISC-Mediated PPM1B-K63 Deubiquitination and Subsequent TGF-β Pathway Activation Promote High-Fat/High-Sucrose Diet-Induced Arterial Stiffness., PMID:39742393
Magnesium-dependent-protein phosphatase 1B regulates the protein arginine methyltransferase 5 through the modulation of myosin phosphatase., PMID:39706272
Icariin promotes functional recovery in rats after spinal cord injury by inhibiting YAP and regulating PPM1B ubiquitination to inhibiting the activation of reactive astrocytes., PMID:39439899
Application of large-scale and multicohort plasma proteomics data to discover novel causal proteins in gastric cancer., PMID:39422802
MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy., PMID:38783090
Epithelial-mesenchymal transition induced by tumor cell-intrinsic PD-L1 signaling predicts a poor response to immune checkpoint inhibitors in PD-L1-high lung cancer., PMID:38729997
Modulation of YBX1-mediated PANoptosis inhibition by PPM1B and USP10 confers chemoresistance to oxaliplatin in gastric cancer., PMID:38364962
Phosphatase, Mg2+/Mn2+ dependent 1B regulates the hematopoietic stem cells homeostasis via the Wnt/β-catenin signaling., PMID:38328859
RBM10 regulates the tumorigenic potential of human cancer cells by modulating PPM1B and YBX1 activities., PMID:38246397
A noncanonical function of SKP1 regulates the switch between autophagy and unconventional secretion., PMID:37831778
Overexpression of PPM1B inhibited chemoresistance to temozolomide and proliferation in glioma cells., PMID:37798941
Circ_0006251 mediates the proliferation and apoptosis of vascular smooth muscle cells in CAD via enhancing TET3 and PPM1B expression., PMID:37715433
Circ_0090231 knockdown protects vascular smooth muscle cells from ox-LDL-induced proliferation, migration and invasion via miR-942-5p/PPM1B axis during atherosclerosis., PMID:37515673
TXLNA enhances TBK1 phosphorylation by suppressing PPM1B recruitment., PMID:37506885
Pleckstrin-2-promoted PPM1B degradation plays an important role in transforming growth factor-β-induced breast cancer cell invasion and metastasis., PMID:36928924
A comprehensive overview of PPM1B: From biological functions to diseases., PMID:36863552
Landscape of pathogenic mutations in premature ovarian insufficiency., PMID:36732629
YWHAE/14-3-3ε crotonylation regulates leucine deprivation-induced autophagy., PMID:36628438
Lysine crotonylation regulates leucine-deprivation-induced autophagy by a 14-3-3ε-PPM1B axis., PMID:36543144
Protein Phosphatase PPM1B Inhibits Gastric Cancer Progression and Serves as a Favorable Prognostic Biomarker., PMID:35319516
Yes-Associated Protein Targets the Transforming Growth Factor β Pathway to Mediate High-Fat/High-Sucrose Diet-induced Arterial Stiffness., PMID:35176871
Lung transcriptome analysis for the identification of genes involved in the hypoxic adaptation of plateau pika (Ochotona curzoniae)., PMID:34861554
Exosomal miR-181a-5p reduce Mycoplasma gallisepticum (HS strain) infection in chicken by targeting PPM1B and activating the TLR2-mediated MyD88/NF-κB signaling pathway., PMID:34715577
USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade., PMID:34381028
[TRIM59 regulates invasion and migration of nasopharyngeal carcinoma cells by targeted modulation of PPM1B]., PMID:34308852
Thyroarytenoid Muscle Gene Expression in a Rat Model of Early-Onset Parkinson's Disease., PMID:34057223
PRKAA/AMPKα phosphorylation switches the role of RASAL2 from a suppressor to an activator of autophagy., PMID:33563064
Ppm1b Negatively Regulates 3-Bromopyruvate Induced Necroptosis in Breast Cancer Cells., PMID:33520691
Protein phosphatase PPM1B inhibits DYRK1A kinase through dephosphorylation of pS258 and reduces toxic tau aggregation., PMID:33380426
Beneficial actions of the [A14K] analog of the frog skin peptide PGLa-AM1 in mice with obesity and degenerative diabetes: A mechanistic study., PMID:33338546
Mechanisms of action of the antidiabetic peptide [S4K]CPF-AM1 in db/db mice., PMID:33252358
Clostridium difficile toxin B-induced colonic inflammation is mediated by the FOXO3/PPM1B pathway in fetal human colon epithelial cells., PMID:33194024
Identification of HN252 as a potent inhibitor of protein phosphatase PPM1B., PMID:33048454
Relationship between the Levels of mRNA Expression for Protein Phosphatase 1B and Proteins Involved in Cytoskeleton Remodeling in Squamous Cell Carcinoma of the Larynx and Hypopharynx., PMID:32915364
Berberine Improves Inflammatory Responses of Diabetes Mellitus in Zucker Diabetic Fatty Rats and Insulin-Resistant HepG2 Cells through the PPM1B Pathway., PMID:32908938
Metal-dependent Ser/Thr protein phosphatase PPM family: Evolution, structures, diseases and inhibitors., PMID:32650009
TRIM59 promotes tumor growth in hepatocellular carcinoma and regulates the cell cycle by degradation of protein phosphatase 1B., PMID:31875525
TBK1 Is a Synthetic Lethal Target in Cancer with VHL Loss., PMID:31810986
A heterozygous deficiency in protein phosphatase Ppm1b results in an altered ovulation number in mice., PMID:31059097
Identification of biomarkers associated with the recurrence of osteosarcoma using ceRNA regulatory network analysis., PMID:30816442
Interactome analysis of the human Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 (hMTr1) protein., PMID:30320910
Potentially critical roles of TNPO1, RAP1B, ZDHHC17, and PPM1B in the progression of coronary atherosclerosis through microarray data analysis., PMID:30269354
Infection Reveals a Modification of SIRT2 Critical for Chromatin Association., PMID:29694890
PPM1B depletion in U2OS cells supresses cell growth through RB1-E2F1 pathway and stimulates bleomycin-induced cell death., PMID:29654756
Clinical Utility of Cell-Free DNA for the Detection of ALK Fusions and Genomic Mechanisms of ALK Inhibitor Resistance in Non-Small Cell Lung Cancer., PMID:29599410
Protein phosphatase 1B dephosphorylates Rho guanine nucleotide dissociation inhibitor 1 and suppresses cancer cell migration and invasion., PMID:29307615
PREPL deficiency: delineation of the phenotype and development of a functional blood assay., PMID:28726805
NV Proteins of Fish Novirhabdovirus Recruit Cellular PPM1Bb Protein Phosphatase and Antagonize RIG-I-Mediated IFN Induction., PMID:28276468
For research use only. Not for human or drug use.
