Catalog No.
YHB13201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Leu188
Predicted molecular weight
23.16 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75223
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Gamma-glutamylcyclotransferase, 4.3.2.9, Cytochrome c-releasing factor 21, GGCT, C7orf24, CRF21
Depletion of γ-glutamyl cyclotransferase suppresses the proliferation, migration and invasion of breast cancer cells accompanied by the activation of PI3K/AKT/mTOR pathway., PMID:40481104
DsGGCT2-1 involved in the detoxification of Cd and Pb through the glutathione catabolism in Dianthus spiculifolius., PMID:40344818
On the utility of immobilized phenylarsine oxide in the study of redox sensitive cardiac proteins., PMID:40319072
GGCT Inhibits Ferroptosis in PTC Cells by Upregulating p53 Through RPS15A., PMID:40044122
Host Plasma Microenvironment in Immunometabolically Impaired HIV Infection Leads to Dysregulated Monocyte Function and Synaptic Transmission Ex Vivo., PMID:40013867
Oxidative stress induced protein aggregation via GGCT produced pyroglutamic acid in drug resistant glioblastoma., PMID:39949960
GGCT participates in the malignant process of hepatocellular cancer cells by regulating the PTEN/PI3K/AKT pathway through binding to EZH2., PMID:39918720
Low-frequency variants in genes involved in glutamic acid metabolism and γ-glutamyl cycle and risk of coronary artery disease in type 2 diabetes., PMID:39538235
γ-Glutamylcyclotransferase is transcriptionally regulated by c-Jun and controls proliferation of glioblastoma stem cells through Notch1 levels., PMID:39394529
Desert Hedgehog Down-regulation Mediates Inhibition of Proliferation by γ-Glutamylcyclotransferase Knockdown in Murine Glioblastoma Stem Cells., PMID:39191500
Myc upregulates Ggct, γ-glutamylcyclotransferase to promote development of p53-deficient osteosarcoma., PMID:38924236
Genome-wide identification and analysis of the GGCT gene family in wheat., PMID:38177998
Prediction of Tumor Microenvironment Characteristics and Treatment Response in Lung Squamous Cell Carcinoma by Pseudogene OR7E47P-related Immune Genes., PMID:38015361
Development of a thyroid cancer prognostic model based on the mitophagy-associated differentially expressed genes., PMID:37707688
Identification of c-Met as a novel target of γ-glutamylcyclotransferase., PMID:37488242
Development of an activity-based chemiluminogenic probe for γ-glutamylcyclotransferase., PMID:37434538
Association of ATG7 gene polymorphisms with microscopic polyangiitis in Chinese individuals., PMID:36398269
Interaction of MRPL9 and GGCT Promotes Cell Proliferation and Migration by Activating the MAPK/ERK Pathway in Papillary Thyroid Cancer., PMID:36233293
Susceptibility Loci in SLC15A1, UGT1A3, and CWC27 Genes Associated with Bladder Cancer in the Northeast Chinese Population., PMID:36124064
Biocomputational characterisation of MBO_200107 protein of Mycobacterium tuberculosis variant caprae: a molecular docking and simulation study., PMID:36039775
Glutathione degradation activity of γ-glutamyl peptidase 1 manifests its dual roles in primary and secondary sulfur metabolism in Arabidopsis., PMID:35932489
Host-specific activation of a pathogen effector Aave_4606 from Acidovorax citrulli, the causal agent for bacterial fruit blotch., PMID:35636254
Administration of Gapmer-type Antisense Oligonucleotides Targeting γ-Glutamylcyclotransferase Suppresses the Growth of A549 Lung Cancer Xenografts., PMID:35220212
MiR-205-5p/GGCT Attenuates Growth and Metastasis of Papillary Thyroid Cancer by Regulating CD44., PMID:35213720
Fluorizoline Blocks the Interaction between Prohibitin-2 and γ-Glutamylcyclotransferase and Induces p21Waf1/Cip1 Expression in MCF7 Breast Cancer Cells., PMID:34862308
[The expression of GGCT in the bladder urothelial cell carcinoma and its clinical significance]., PMID:34794221
Identification and Validation of a PPP1R12A-Related Five-Gene Signature Associated With Metabolism to Predict the Prognosis of Patients With Prostate Cancer., PMID:34484299
Ggct (γ-glutamyl cyclotransferase) plays an important role in erythrocyte antioxidant defense and red blood cell survival., PMID:34409610
Distribution of alleles, genotypes and haplotypes of the CYP2B6 (rs3745274; rs2279343) and CYP3A4 (rs2740574) genes in the Malian population: Implication for pharmacogenetics., PMID:34398016
γ-Glutamylcyclotransferase, a novel regulator of HIF-1α expression, triggers aerobic glycolysis., PMID:33402732
Characterization of the mechanism of thioredoxin-dependent activation of γ-glutamylcyclotransferase, RipAY, from Ralstonia solanacearum., PMID:31948763
Alterations of Brain Quantitative Proteomics Profiling Revealed the Molecular Mechanisms of Diosgenin against Cerebral Ischemia Reperfusion Effects., PMID:31940440
γ-Glutamyl cyclotransferase contributes to endometrial carcinoma malignant progression and upregulation of PD-L1 expression during activation of epithelial-mesenchymal transition., PMID:31757677
Effects of the programmed cell death 1 (PDCD1) polymorphisms in susceptibility to systemic lupus erythematosus., PMID:31565862
Depletion of gamma-glutamylcyclotransferase inhibits cancer cell growth by activating the AMPK-FOXO3a-p21 axis., PMID:31345573
Inhibition of EP2/EP4 prostanoid receptor-mediated signaling suppresses IGF-1-induced proliferation of pancreatic cancer BxPC-3 cells via upregulating γ-glutamyl cyclotransferase expression., PMID:31217077
Pro-GA, a Novel Inhibitor of γ-Glutamylcyclotransferase, Suppresses Human Bladder Cancer Cell Growth., PMID:30952730
Comprehensive investigation of the gene expression system regulated by an Aspergillus oryzae transcription factor XlnR using integrated mining of gSELEX-Seq and microarray data., PMID:30621576
iTRAQ-Based Quantitative Proteomics Approach Identifies Novel Diagnostic Biomarkers That Were Essential for Glutamine Metabolism and Redox Homeostasis for Gastric Cancer., PMID:30485682
Association of vascular endothelial growth factor expression and polymorphisms with the risk of gestational diabetes mellitus., PMID:30350881
Depletion of gamma-glutamylcyclotransferase in cancer cells induces autophagy followed by cellular senescence., PMID:29736310
γ-Glutamyl cyclotransferase contributes to tumor progression in high grade serous ovarian cancer by regulating epithelial-mesenchymal transition via activating PI3K/AKT/mTOR pathway., PMID:29429592
Prohibitin-2 is a novel regulator of p21WAF1/CIP1 induced by depletion of γ-glutamylcyclotransferase., PMID:29307834
Polymorphisms of DNA repair genes XRCC1 and LIG4 and idiopathic male infertility., PMID:28991497
Targeting redox homeostasis in rhabdomyosarcoma cells: GSH-depleting agents enhance auranofin-induced cell death., PMID:28981107
Proteomics analysis of human placenta reveals glutathione metabolism dysfunction as the underlying pathogenesis for preeclampsia., PMID:28705740
ChaC2, an Enzyme for Slow Turnover of Cytosolic Glutathione., PMID:27913623
The Ralstonia solanacearum type III effector RipAY targets plant redox regulators to suppress immune responses., PMID:27768829
Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation., PMID:27658708
Role of γ-glutamyl cyclotransferase as a therapeutic target for colorectal cancer based on the lentivirus-mediated system., PMID:27500968
For research use only. Not for human or drug use.
