Catalog No.
YHA97601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu212-Gln531
Predicted molecular weight
38.38 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60678
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein arginine N-methyltransferase 3, 2.1.1.319, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 3, PRMT3, HRMT1L3
Arginine methylation patterns in LUAD: defining prognostic subtypes and relevance to immunotherapy., PMID:40399547
PRMT3 reverses HIV-1 latency by increasing chromatin accessibility to form a TEAD4-P-TEFb-containing transcriptional hub., PMID:40374607
PRMT3-Mediated H4R3me2a Promotes Primary Age-Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron., PMID:40344412
Discovery of a first-in-class protein arginine methyltransferase 1 (PRMT1) degrader for nonenzymatic functions studies., PMID:40245820
PRMT3 drives PD-L1-mediated immune escape through activating PDHK1-regulated glycolysis in hepatocellular carcinoma., PMID:40050608
PRMT3 and CARM1: Emerging Epigenetic Targets in Cancer., PMID:39964832
PRMT3 gene expression and methylation levels in arrested embryos: Implications for developmental arrest defects., PMID:39892499
The uncharacterized protein ZNF200 interacts with PRMT3 and aids its stability and nuclear translocation., PMID:39513743
Targeting PRMT3 impairs methylation and oligomerization of HSP60 to boost anti-tumor immunity by activating cGAS/STING signaling., PMID:39256398
Type I arginine methyltransferases play crucial roles in development and pathogenesis of Phytophthora capsici., PMID:39151856
Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia., PMID:39120042
Chicken PRMT3 facilitates IBDV replication., PMID:38981362
Fine mapping and candidate gene analysis of Dravet syndrome modifier loci on mouse chromosomes 7 and 8., PMID:38862622
PRMT3 methylates HIF-1α to enhance the vascular calcification induced by chronic kidney disease., PMID:38200452
A unique binding pocket induced by a noncanonical SAH mimic to develop potent and selective PRMT inhibitors., PMID:38045046
PRMT3-Mediated Arginine Methylation of METTL14 Promotes Malignant Progression and Treatment Resistance in Endometrial Carcinoma., PMID:37973560
Asymmetric arginine dimethylation of cytosolic RNA and DNA sensors by PRMT3 attenuates antiviral innate immunity., PMID:37639603
Arginine methyltransferases PRMT2 and PRMT3 are essential for biosynthesis of plant-polysaccharide-degrading enzymes in Penicillium oxalicum., PMID:37523410
Asymmetric Dimethylation of Ribosomal S6 Kinase 2 Regulates Its Cellular Localisation and Pro-Survival Function., PMID:37240151
Ribosomal Protein uS5 and Friends: Protein-Protein Interactions Involved in Ribosome Assembly and Beyond., PMID:37238722
PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer., PMID:37024475
PRMT3 regulates the progression of invasive micropapillary carcinoma of the breast., PMID:36637351
Design, synthesis and evaluation of antitumor activity of selective PRMT6 inhibitors., PMID:36566712
Protein arginine methyltransferase 3: A crucial regulator in metabolic reprogramming and gene expression in cancers., PMID:36400311
PRMT3 drives glioblastoma progression by enhancing HIF1A and glycolytic metabolism., PMID:36351894
Type I arginine methyltransferases are intervention points to unveil the oncogenic Epstein-Barr virus to the immune system., PMID:36350639
Protein arginine methyltransferase 3 inhibits renal tubulointerstitial fibrosis through asymmetric dimethylarginine., PMID:36177327
Elucidating the role of PRMTs in prostate cancer using open access databases and a patient cohort dataset., PMID:36082942
Functional Study of Leishmania braziliensis Protein Arginine Methyltransferases (PRMTs) Reveals That PRMT1 and PRMT5 Are Required for Macrophage Infection., PMID:35226477
Protein arginine methyltransferase 3 promotes glycolysis and hepatocellular carcinoma growth by enhancing arginine methylation of lactate dehydrogenase A., PMID:35090076
PRMT3 inhibitor SGC707 reduces triglyceride levels and induces pruritus in Western-type diet-fed LDL receptor knockout mice., PMID:35013582
PRMT3 promotes tumorigenesis by methylating and stabilizing HIF1α in colorectal cancer., PMID:34753906
Decreased nitric oxide content mediated by asymmetrical dimethylarginine and protein l-arginine methyltransferase 3 in macrophages induces trophoblast apoptosis: a potential cause of recurrent miscarriage., PMID:34647126
The macromolecular complexes of histones affect protein arginine methyltransferase activities., PMID:34492270
A meta-analysis of transcriptomic profiles of Huntington's disease patients., PMID:34111223
Arginine methyltransferase PRMT3 promote tumorigenesis through regulating c-MYC stabilization in colorectal cancer., PMID:33991650
Identification of a cartilage specific novel miRNA which directly targets PRMT3 in rats., PMID:36474992
PRMT3 interacts with ALDH1A1 and regulates gene-expression by inhibiting retinoic acid signaling., PMID:33495566
Iron deficiency negatively regulates protein methylation via the downregulation of protein arginine methyltransferase., PMID:33033759
Zebrafish prmt3 negatively regulates antiviral responses., PMID:32643209
Asymmetrical methyltransferase PRMT3 regulates human mesenchymal stem cell osteogenesis via miR-3648., PMID:31378783
Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer., PMID:31324208
Cisplatin-induced ototoxicity involves interaction of PRMT3 and cannabinoid system., PMID:31256211
Inhibition of PRMT3 activity reduces hepatic steatosis without altering atherosclerosis susceptibility in apoE knockout mice., PMID:30776415
Protein Arginine Methyltransferase 3 Enhances Chemoresistance in Pancreatic Cancer by Methylating hnRNPA1 to Increase ABCG2 Expression., PMID:30577570
The 40S ribosomal protein uS5 (RPS2) assembles into an extraribosomal complex with human ZNF277 that competes with the PRMT3-uS5 interaction., PMID:30530495
Inhibition of protein arginine methyltransferase 3 activity selectively impairs liver X receptor-driven transcription of hepatic lipogenic genes in vivo., PMID:29774529
Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization., PMID:29471495
mRNA expression profiling of histone modifying enzymes in pediatric acute monoblastic leukemia., PMID:29442054
[Transcription of protein arginine N-methyltransferase genes in mouse dorsal root ganglia following peripheral nerve injury]., PMID:29292255
For research use only. Not for human or drug use.
