Catalog No.
YHA95101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu53-Pro245
Predicted molecular weight
24.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60573
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Eukaryotic translation initiation factor 4E type 2, eIF-4E type 2, eIF4E type 2, Eukaryotic translation initiation factor 4E homologous protein, Eukaryotic translation initiation factor 4E-like 3, eIF4E-like protein 4E-LP, mRNA cap-binding protein 4EHP, h4EHP, mRNA cap-binding protein type 3, EIF4E2, EIF4EL3
EIF4E1B interacts with HSPA1A and PPP2CA and is involved in mouse oocyte maturation and early embryonic development., PMID:40139147
PARP inhibitor radiosensitization enhances anti-PD-L1 immunotherapy through stabilizing chemokine mRNA in small cell lung cancer., PMID:40038278
Hypoxia-induced translation of collagen-modifying enzymes PLOD2 and P4HA1 is dependent on RBM4 and eIF4E2 in human colon cancer HCT116 cells., PMID:39710969
Dysregulated RBM24 phosphorylation impairs APOE translation underlying psychological stress-induced cardiovascular disease., PMID:39580475
Adolescent exposure to organophosphate insecticide malathion induces spermatogenesis dysfunction in mice by activating the HIF-1/MAPK/PI3K pathway., PMID:39476999
Edited eukaryotic translation initiation factors confer resistance against maize lethal necrosis., PMID:39403866
Stress-Induced Eukaryotic Translational Regulatory Mechanisms., PMID:39364184
Stress-induced Eukaryotic Translational Regulatory Mechanisms., PMID:38745702
α1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation., PMID:37798282
The SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression., PMID:37732428
Interaction of Solanum tuberosum L. translation initiation factors eIF4E with potato virus Y VPg: Apprehend and avoid., PMID:37562705
Identification of m7G-related hub biomarkers and m7G regulator expression pattern in immune landscape during the progression of osteoarthritis., PMID:37549488
SARS-CoV-2 viral protein Nsp2 stimulates translation under normal and hypoxic conditions., PMID:36998012
Evaluation of Krill Meal in Commercial Diets for Juvenile Swimming Crab (Portunus trituberculatus)., PMID:36860462
METTL16 promotes translation and lung tumorigenesis by sequestering cytoplasmic eIF4E2., PMID:36840945
Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP., PMID:36650535
Effects of Compound Feed Attractants on Growth Performance, Feed Utilization, Intestinal Histology, Protein Synthesis, and Immune Response of White Shrimp (Litopenaeus Vannamei)., PMID:36230291
Roles and interactions of the specialized initiation factors EIF4E2, EIF4E5, and EIF4E6 in Trypanosoma brucei: EIF4E2 maintains the abundances of S-phase mRNAs., PMID:36056730
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation., PMID:35878012
Interplay between SERCA, 4E-BP, and eIF4E in the Drosophila heart., PMID:35588119
Mammalian eIF4E2-GSK3β maintains basal phosphorylation of p53 to resist senescence under hypoxia., PMID:35568694
Mechanistic insights of key host proteins and potential repurposed inhibitors regulating SARS-CoV-2 pathway., PMID:35535951
Effect of bovine lactoferricin on the growth performance, digestive capacity, immune responses and disease resistance in Pacific white shrimp, Penaeus vannamei., PMID:35306176
CRISPR-based knock-out of eIF4E2 in a cherry tomato background successfully recapitulates resistance to pepper veinal mottle virus., PMID:35151441
Kaposi's sarcoma herpesvirus activates the hypoxia response to usurp HIF2α-dependent translation initiation for replication and oncogenesis., PMID:34965440
Circular RNA-associated ceRNA network involved in HIF-1 signalling in triple-negative breast cancer: circ_0047303 as a potential key regulator., PMID:34791795
eIF4E-homologous protein (4EHP): a multifarious cap-binding protein., PMID:34758096
Translational repression of NMD targets by GIGYF2 and EIF4E2., PMID:34665823
VPg of Potato Virus Y and Potato Cap-Binding eIF4E Factors: Selective Interaction and Its Supposed Mechanism., PMID:34565316
Translation Initiation Regulated by RNA-Binding Protein in Mammals: The Modulation of Translation Initiation Complex by Trans-Acting Factors., PMID:34359885
capCLIP: a new tool to probe translational control in human cells through capture and identification of the eIF4E-mRNA interactome., PMID:34255842
RNA Binding Proteins As Regulators of Oxidative Stress Identified by a Targeted CRISPR-Cas9 Single Guide RNA Library., PMID:34096786
Global alternative splicing landscape of skeletal muscle atrophy induced by hindlimb unloading., PMID:33987341
eIF4E3 forms an active eIF4F complex during stresses (eIF4FS) targeting mTOR and re-programs the translatome., PMID:33893802
High EIF4E2 expression is an independent prognostic risk factor for poor overall survival and recurrence-free survival in uveal melanoma., PMID:33785306
microRNA-induced translational control of antiviral immunity by the cap-binding protein 4EHP., PMID:33581076
Hypoxia-inducible Factor-1α Suppression in Ovarian Clear-cell Carcinoma Cells by Silibinin Administration., PMID:33288572
The eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior., PMID:33225984
4EHP and GIGYF1/2 Mediate Translation-Coupled Messenger RNA Decay., PMID:33053355
The current landscape of coronavirus-host protein-protein interactions., PMID:32811513
EDF1 coordinates cellular responses to ribosome collisions., PMID:32744497
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control., PMID:32726578
Autoantibody profiling identifies predictive biomarkers of response to anti-PD1 therapy in cancer patients., PMID:32483460
DEAD Box Protein Family Member DDX28 Is a Negative Regulator of Hypoxia-Inducible Factor 2α- and Eukaryotic Initiation Factor 4E2-Directed Hypoxic Translation., PMID:31907278
The Zebrafish Xenograft Platform-A Novel Tool for Modeling KSHV-Associated Diseases., PMID:31861850
Knock-out mutation of eukaryotic initiation factor 4E2 (eIF4E2) confers resistance to pepper veinal mottle virus in tomato., PMID:31622792
Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells., PMID:31336098
A complex eIF4E locus impacts the durability of va resistance to Potato virus Y in tobacco., PMID:31115167
A threonyl-tRNA synthetase-mediated translation initiation machinery., PMID:30902983
hnRNPM induces translation switch under hypoxia to promote colon cancer development., PMID:30852162
For research use only. Not for human or drug use.
