Catalog No.
YHA90101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly240-Lys371
Predicted molecular weight
17.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60393
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Homeobox protein NOBOX, NOBOX
Reclassifying NOBOX variants in primary ovarian insufficiency cases with a corrected gene model and a novel quantitative framework., PMID:40246288
Oocyte/zygote/embryo maturation arrest: a clinical study expanding the phenotype of NOBOX variants., PMID:39871066
Molecular cloning of PRD-like homeobox genes expressed in bovine oocytes and early IVF embryos., PMID:39506635
Whole-genome de novo sequencing reveals genomic variants associated with differences of sex development in SRY negative pigs., PMID:39223676
Prenatal acetaminophen exposure and the developing ovary: Time, dose, and course consequences for fetal mice., PMID:38657942
Perinatal bisphenol S exposure exacerbates the oxidative burden and apoptosis in neonatal ovaries by suppressing the mTOR/autophagy axis., PMID:38593938
Association between polymorphisms in NOBOX and litter size traits in Xiangsu pigs., PMID:38523712
Reconstruction of ovarian follicular-like structure by recellularization of a cell-free human ovarian scaffold with mouse fetal ovarian cells., PMID:38304626
NOBOX gene variants in premature ovarian insufficiency: ethnicity-dependent insights., PMID:37921973
Dynamic role of Scd1 gene during mouse oocyte growth and maturation., PMID:37315672
Sohlh1 and Lhx8 are prominent biomarkers to estimate the primordial follicle pool in mice., PMID:37194006
Selected Genetic Factors Associated with Primary Ovarian Insufficiency., PMID:36901862
SRSF1 regulates primordial follicle formation and number determination during meiotic prophase I., PMID:36882745
Sumoylation regulates functional properties of the oocyte transcription factors SOHLH1 and NOBOX., PMID:36607631
In vivo and in vitro matured bovine oocytes present a distinct pattern of single-cell gene expression., PMID:36263617
Loss of Nobox prevents ovarian differentiation from juvenile ovaries in zebrafish., PMID:35157068
BCAS2 is involved in alternative splicing and mouse oocyte development., PMID:34972250
Genetics of ovarian insufficiency and defects of folliculogenesis., PMID:34794894
Transcriptome Analyses Identify Potential Key microRNAs and Their Target Genes Contributing to Ovarian Reserve., PMID:34639162
Bone marrow-derived mesenchymal stem cells combined with gonadotropin therapy restore postnatal oogenesis of chemo-ablated ovaries in rats via enhancing very small embryonic-like stem cells., PMID:34579781
Compound heterozygous null mutations of NOBOX in sisters with delayed puberty and primary amenorrhea., PMID:34480423
Premature ovarian insufficiency - the need for a genomic map., PMID:34308731
Long-term persistence of supernumerary B chromosomes in multiple species of Astyanax fish., PMID:33740955
Di (2-ethylhexyl) phthalate impairs primordial follicle assembly by increasing PDE3A expression in oocytes., PMID:33234378
The Potential Synergic Effect of a Complex Pattern of Multiple Inherited Genetic Variants as a Pathogenic Factor for Ovarian Dysgenesis: A Case Report., PMID:33101191
The antiandrogenic vinclozolin induces differentiation delay of germ cells and changes in energy metabolism in 3D cultures of fetal ovaries., PMID:33093579
foxl3, a sexual switch in germ cells, initiates two independent molecular pathways for commitment to oogenesis in medaka., PMID:32409601
FIGLA, LHX8 and SOHLH1 transcription factor networks regulate mouse oocyte growth and differentiation., PMID:32086523
Basal characterization and in vitro differentiation of putative stem cells derived from the adult mouse ovary., PMID:31900800
Specific activation of the hb4 gene in the Xenopus oocyte through a Nobox-binding element located at the proximal promoter sequence., PMID:31250783
Clinical and Genetic Investigation of Premature Ovarian Insufficiency Cases from Turkey., PMID:31026518
Oocyte-derived E-cadherin acts as a multiple functional factor maintaining the primordial follicle pool in mice., PMID:30770786
3D-cultured human placenta-derived mesenchymal stem cell spheroids enhance ovary function by inducing folliculogenesis., PMID:30333505
[Therapeutic potential of BMSCs for premature ovarian failure in mice]., PMID:30154285
Folliculogenic factors in photoregressed ovaries: Differences in mRNA expression in early compared to late follicle development., PMID:29317212
A novel homozygous 1-bp deletion in the NOBOX gene in two Brazilian sisters with primary ovarian failure., PMID:29067606
Observation of the influences of diosgenin on aging ovarian reserve and function in a mouse model., PMID:29047400
New MCM8 mutation associated with premature ovarian insufficiency and chromosomal instability in a highly consanguineous Tunisian family., PMID:28863940
R-spondin2, a novel target of NOBOX: identification of variants in a cohort of women with primary ovarian insufficiency., PMID:28743298
Transcription factors SOHLH1 and SOHLH2 coordinate oocyte differentiation without affecting meiosis I., PMID:28504655
Zearalenone exposure impairs ovarian primordial follicle formation via down-regulation of Lhx8 expression in vitro., PMID:28089945
A homozygous NOBOX truncating variant causes defective transcriptional activation and leads to primary ovarian insufficiency., PMID:27836978
Impaired protein stability and nuclear localization of NOBOX variants associated with premature ovarian insufficiency., PMID:27798098
Identification of Multiple Gene Mutations Accounts for a new Genetic Architecture of Primary Ovarian Insufficiency., PMID:27603904
Characterization and target genes of nine human PRD-like homeobox domain genes expressed exclusively in early embryos., PMID:27412763
TAF4b Regulates Oocyte-Specific Genes Essential for Meiosis., PMID:27341508
Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice., PMID:27050391
NOBOX is a strong autosomal candidate gene in Tunisian patients with primary ovarian insufficiency., PMID:26848058
Gap junctions are essential for murine primordial follicle assembly immediately before birth., PMID:26554027
Identification and Analysis of Regulatory Elements in Porcine Bone Morphogenetic Protein 15 Gene Promoter., PMID:26516845
For research use only. Not for human or drug use.
