Catalog No.
YHA76701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp13-Lys196
Predicted molecular weight
23.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43745
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calcineurin B homologous protein 2, Hepatocellular carcinoma-associated antigen 520, CHP2, HCA520
The HP1 hinge region: more than just a linker for heterochromatin., PMID:40152110
Characterization of the Swi6/HP1 binding motif in its partner protein reveals the basis for the functional divergence of the HP1 family proteins in fission yeast., PMID:39945308
CHP2 Modifies Chronic Pseudomonas aeruginosa Airway Infection Risk in Cystic Fibrosis., PMID:39746161
Multiple Machine Learning Models, Molecular Subtyping and Singlecell Analysis Identify PANoptosis-related Core Genes and their Association with Subtypes in Crohn's Disease., PMID:39440782
The Structure of Spiroplasma Virus 4: Exploring the Capsid Diversity of the Microviridae., PMID:39066266
Chromone-embedded peptidomimetics and furopyrimidines as highly potent SARS-CoV-2 infection inhibitors: docking and MD simulation study., PMID:37735703
Cooperative DNA-binding activities of Chp2 are critical for its function in heterochromatin assembly., PMID:37400983
Establishment of a BRAF V595E-mutant canine prostate cancer cell line and the antitumor effects of MEK inhibitors against canine prostate cancer., PMID:36745053
Transplantation in CML in the TKI era: who, when, and how?, PMID:36485123
Artificial Neural Network Analysis-Based Immune-Related Signatures of Primary Non-Response to Infliximab in Patients With Ulcerative Colitis., PMID:34992592
Genome-wide association study in patients with pulmonary Mycobacterium avium complex disease., PMID:33542050
[The malignant phenotype of calcineurin B homologous protein 2 in gastric cancer and its clinical significance]., PMID:33342147
Involvement of CHP2 in the Development of Non-Small Cell Lung Cancer and Patients' Poor Prognosis., PMID:33030853
Calcium affects CHP1 and CHP2 conformation and their interaction with sodium/proton exchanger 1., PMID:31912575
Differential functional patterns of memory CD4+ and CD8+ T-cells from volunteers immunized with Ty21a typhoid vaccine observed using a recombinant Escherichia coli system expressing S. Typhi proteins., PMID:31629569
Overlapping Roles in Chromosome Segregation for Heterochromatin Protein 1 (Swi6) and DDK in Schizosaccharomyces pombe., PMID:31000521
Isolation and identification of iron-chelating peptides from casein hydrolysates., PMID:30993279
Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1., PMID:30808655
Heterochromatin suppresses gross chromosomal rearrangements at centromeres by repressing Tfs1/TFIIS-dependent transcription., PMID:30652128
Composition characterization of oyster polysaccharides from Crassostrea hongkongensis and their protective effect against H2O2-induced oxidative damage in IEC-6 cells., PMID:30452991
The binding of Chp2's chromodomain to methylated H3K9 is essential for Chp2's role in heterochromatin assembly in fission yeast., PMID:30110338
CHP2 Promotes Cell Proliferation in Breast Cancer via Suppression of FOXO3a., PMID:29967111
Self-selection of plant bioactive compounds by sheep in response to challenge infection with Haemonchus contortus., PMID:29906471
Biochemical Basis for Distinct Roles of the Heterochromatin Proteins Swi6 and Chp2., PMID:28942089
Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription., PMID:28682306
Gene-Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-Based Microarray Analysis., PMID:26136121
CHP2 gene expression and quantitation in Egyptian patients with acute leukemia., PMID:25606416
The rv1184c locus encodes Chp2, an acyltransferase in Mycobacterium tuberculosis polyacyltrehalose lipid biosynthesis., PMID:25331437
Biosynthesis and translocation of unsulfated acyltrehaloses in Mycobacterium tuberculosis., PMID:25124040
A new 12-gene diagnostic biomarker signature of melanoma revealed by integrated microarray analysis., PMID:23638386
Calcineurin homologous protein: a multifunctional Ca2+-binding protein family., PMID:22189947
Identification, sequencing and molecular analysis of Chp4, a novel chlamydiaphage of Chlamydophila abortus belonging to the family Microviridae., PMID:21450942
Nuclear accumulation of calcineurin B homologous protein 2 (CHP2) results in enhanced proliferation of tumor cells., PMID:21392185
Asf1/HIRA facilitate global histone deacetylation and associate with HP1 to promote nucleosome occupancy at heterochromatic loci., PMID:21211723
Combinatorial, site-specific requirement for heterochromatic silencing factors in the elimination of nucleosome-free regions., PMID:20675407
A chromodomain switch mediated by histone H3 Lys 4 acetylation regulates heterochromatin assembly., PMID:20299449
[Tumor associated antigen CHP2 promotes intraperitoneal metastasis of HEK293 cells in nude mice]., PMID:19829666
Diverse roles of HP1 proteins in heterochromatin assembly and functions in fission yeast., PMID:19443688
HP1 proteins form distinct complexes and mediate heterochromatic gene silencing by nonoverlapping mechanisms., PMID:19111658
CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells., PMID:18815128
Balance between distinct HP1 family proteins controls heterochromatin assembly in fission yeast., PMID:18809570
[Expression of a tumor related gene chp2 in leukemia cells]., PMID:18718049
Behind the chlamydial cloak: the replication cycle of chlamydiaphage Chp2, revealed., PMID:18570973
Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform., PMID:18321853
Overexpression of CHP2 enhances tumor cell growth, invasion and metastasis in ovarian cancer., PMID:17708351
Intracellular parasitism of chlamydiae: specific infectivity of chlamydiaphage Chp2 in Chlamydophila abortus., PMID:17468245
Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation., PMID:16710297
Crystallization and preliminary crystallographic analysis of the human calcineurin homologous protein CHP2 bound to the cytoplasmic region of the Na+/H+ exchanger NHE1., PMID:16511206
SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast., PMID:16168376
Chlamydiaphage Chp2, a skeleton in the phiX174 closet: scaffolding protein and procapsid identification., PMID:15516569
For research use only. Not for human or drug use.
