Catalog No.
YHA76301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser403-Arg554
Predicted molecular weight
20.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43734
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 ubiquitin ligase TRAF3IP2, 2.3.2.27, Adapter protein CIKS, Connection to IKK and SAPK/JNK, E3 ubiquitin-protein ligase CIKS, Nuclear factor NF-kappa-B activator 1, ACT1, TRAF3-interacting protein 2, TRAF3IP2, C6orf2, C6orf4, C6orf5, C6orf6
Exosomal miR-202-5p derived from iPSC-MSCs protects against myocardial infarction through inhibition of cardiomyocyte pyroptosis., PMID:40462173
Trichomonas vaginalis extracellular vesicles activate the NLRP3 inflammasome and TLR3-mediated inflammatory cascades in host cells., PMID:40455858
Downregulated TRAF3IP2-AS1 promotes hepatocellular carcinoma progression through the miR-374a-5p/SEL1L1/RPL6 axis to enhance DNA damage repair., PMID:40385018
Exploring the potential anti-COPD ingredients and mechanisms of the Qingfei decoction based on UHPLC-HRMS, network pharmacology and transcriptomic analysis., PMID:39700691
EF24, a Curcumin Analog, Reverses Interleukin-18-Induced miR-30a or miR-342-Dependent TRAF3IP2 Expression, RECK Suppression, and the Proinflammatory Phenotype of Human Aortic Smooth Muscle Cells., PMID:39451191
Rapidly Progressive Primary Cutaneous Gamma Delta T-Cell Lymphoma With FYN Gene Alteration., PMID:39412302
MLN4924 alleviates autoimmune myocarditis by promoting Act1 degradation and blocking Act1-mediated mRNA stability., PMID:39038386
Act1 drives chemoresistance via regulation of antioxidant RNA metabolism and redox homeostasis., PMID:38861022
Psoriasis and Psoriatic Arthritis-Associated Genes, Cytokines, and Human Leukocyte Antigens., PMID:38792999
Large-scale DNA sequencing identifies rare variants associated with Systemic Lupus Erythematosus susceptibility in known risk genes., PMID:38360126
TRAF3IP2 drives mesenchymal stem cell senescence via regulation of NAMPT-mediated NAD biosynthesis., PMID:37809895
Identification of lncRNAs associated with the progression of acute lymphoblastic leukemia using a competing endogenous RNAs network., PMID:37303492
A deep transcriptome meta-analysis reveals sex differences in multiple sclerosis., PMID:37023829
NF-κB Activator 1 downregulation in macrophages activates STAT3 to promote adenoma-adenocarcinoma transition and immunosuppression in colorectal cancer., PMID:36978108
A Familial Novel Putative-Pathogenic Mutation Identified in Plaque-Psoriasis by a Multigene Panel Analysis., PMID:36902182
Therapeutic effects and mechanisms of Ku-Gan formula on atopic dermatitis: A pilot clinical study and modular pharmacology analysis with animal validation., PMID:36716903
IncRNA TRAF3IP2-AS1 Restrains Cervical Cancer Progression by Sponging miR-3677-3p and Acts As a Diagnostic Marker in Cervical Cancer., PMID:36374810
TRAF3IP2-IL-17 Axis Strengthens the Gingival Defense against Pathogens., PMID:36281065
Targeting TRAF3IP2 inhibits angiogenesis in glioblastoma., PMID:36046049
5mC and H3K9me3 of TRAF3IP2 promoter region accelerates the progression of translocation renal cell carcinoma., PMID:35897085
A multilocus genetic study evidences the association of autoimmune-related genes with Psoriatic Arthritis in Italian patients., PMID:35642993
Dihydrosanguinarine based RNA-seq approach couple with network pharmacology attenuates LPS-induced inflammation through TNF/IL-17/PI3K/AKT pathways in mice liver., PMID:35490666
TRAF3IP2 regulated by FOXO4 affects fibroblast proliferation, migration, and extracellular matrix deposition in keloid through the TGF-β1/Smad pathway., PMID:35441794
The Immunogenetics of Psoriasis., PMID:35286693
m6A-related lncRNAs predict prognosis and indicate immune microenvironment in acute myeloid leukemia., PMID:35110624
Biallelic TRAF3IP2 variants causing chronic mucocutaneous candidiasis in a child harboring a STAT1 variant., PMID:34289170
Targeting TRAF3IP2 alleviates high glucose-induced cardiomyocyte inflammation and apoptosis., PMID:34260107
The long non-coding RNA βFaar regulates islet β-cell function and survival during obesity in mice., PMID:34183666
Fusion transcripts FYN-TRAF3IP2 and KHDRBS1-LCK hijack T cell receptor signaling in peripheral T-cell lymphoma, not otherwise specified., PMID:34140493
HDAC8 Activates AKT through Upregulating PLCB1 and Suppressing DESC1 Expression in MEK1/2 Inhibition-Resistant Cells., PMID:34064422
Calcitonin gene-related peptide regulates spinal microglial activation through the histone H3 lysine 27 trimethylation via enhancer of zeste homolog-2 in rats with neuropathic pain., PMID:34020664
Identification of a Long Noncoding RNA TRAF3IP2-AS1 as Key Regulator of IL-17 Signaling through the SRSF10-IRF1-Act1 Axis in Autoimmune Diseases., PMID:33941656
FYN-TRAF3IP2 induces NF-κB signaling-driven peripheral T cell lymphoma., PMID:33928261
A Novel TRAF3IP2 Mutation Causing Chronic Mucocutaneous Candidiasis., PMID:33825088
Low expression of TRAF3IP2-AS1 promotes progression of NONO-TFE3 translocation renal cell carcinoma by stimulating N6-methyladenosine of PARP1 mRNA and downregulating PTEN., PMID:33741027
ACT1 Is Required for Murine IL-23-Induced Psoriasiform Inflammation Potentially Independent of E3 Ligase Activity., PMID:33548244
Detection of selection signatures for response to Aleutian mink disease virus infection in American mink., PMID:33536540
Gene expression in the striatum of cynomolgus monkeys after chronic administration of cocaine and heroin., PMID:33404192
Two patients with chronic mucocutaneous candidiasis caused by TRAF3IP2 deficiency., PMID:33359359
IL-17 promotes proliferation, inflammation and inhibits apoptosis of HaCaT cells via interacting with the TRAF3 interacting protein 2., PMID:33273977
The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion., PMID:33160017
TRAF3IP2 (TRAF3 Interacting Protein 2) Mediates Obesity-Associated Vascular Insulin Resistance and Dysfunction in Male Mice., PMID:32829657
[Construction of ACT-1 human undifferentiated thyroid cancer cell line with knockout of axis inhibition protein 1 (AXIN1) gene using CRISPR/Cas9]., PMID:32696754
Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop., PMID:32696476
Overexpression of SNTG2, TRAF3IP2, and ITGA6 transcripts is associated with osteoporotic vertebral fracture in elderly women from community., PMID:32602654
Minocycline reverses IL-17A/TRAF3IP2-mediated p38 MAPK/NF-κB/iNOS/NO-dependent cardiomyocyte contractile depression and death., PMID:32553549
Targeting TRAF3IP2, Compared to Rab27, is More Effective in Suppressing the Development and Metastasis of Breast Cancer., PMID:32483202
The differential response to anti IL-6 treatment in COVID-19: the genetic counterpart., PMID:32452345
A novel TRAF3IP2 variant causing familial scarring alopecia with mixed features of discoid lupus erythematosus and folliculitis decalvans., PMID:32350852
Ellipticine blocks synergistic effects of IL-17A and TNF-α in epithelial cells and alleviates severe acute pancreatitis-associated acute lung injury., PMID:32335141
For research use only. Not for human or drug use.
