Catalog No.
YHA73901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser31-Thr181
Predicted molecular weight
20.18 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43665
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Regulator of G-protein signaling 10, RGS10, RGS10
RGS10 attenuates systemic immune dysregulation induced by chronic inflammatory stress., PMID:39994765
Genetic variants of accessory proteins and G proteins in human genetic disease., PMID:39743506
Biological sex, microglial signaling pathways, and radiation exposure shape cortical proteomic profiles and behavior in mice., PMID:39677060
RGS10 Attenuates Systemic Immune Dysregulation Induced by Chronic Inflammatory Stress., PMID:39554164
A Phenotypic High-Throughput Screen Identifies Small Molecule Modulators of Endogenous RGS10 in BV-2 Cells., PMID:39547663
RGS10 Deficiency Alleviated Intestinal Mucosal Inflammation Through Suppression of Th1/Th17 Cell Immune Responses in Ulcerative Colitis., PMID:39428350
Responsiveness of anti-VEGF treatment for polypoidal choroidal vasculopathy based on aqueous humour proteomics: A preliminary study., PMID:39420792
Distinct and overlapping RGS14 and RGS12 actions regulate NPT2A-mediated phosphate transport., PMID:39293332
RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer., PMID:39145770
RGS10 mitigates high glucose-induced microglial inflammation via the reactive oxidative stress pathway and enhances synuclein clearance in microglia., PMID:38812790
Epigenetic insights into Familial Mediterranean Fever: Increased RGS10 expression and histone modifications accompanies inflammation in familial Mediterranean fever disease., PMID:38331118
Deciphering Immune-related Gene Signatures in Diabetic Retinopathy: Insights from In silico Analysis and In vitro Experiment., PMID:38310446
RGS10 inhibits proliferation and migration of pulmonary arterial smooth muscle cell in pulmonary hypertension via AKT/mTORC1 signaling., PMID:37879890
RGS10 negatively regulates apical periodontitis via TFEB-mediated autophagy in BABL/c mice model and in vitro., PMID:37092953
Genetic Variants Associated with Suicide Risk in the Mexican Population: A Systematic Literature Review., PMID:36772904
Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis., PMID:36384958
Inhibition of RGS10 Aggravates Periapical Periodontitis via Upregulation of the NF-κB Pathway., PMID:36041584
RGS10 suppression by DNA methylation is associated with low survival rates in colorectal carcinoma., PMID:35810565
Pycard and BC017158 Candidate Genes of Irm1 Locus Modulate Inflammasome Activation for IL-1β Production., PMID:35799794
Inhibition of Rgs10 aggravates periodontitis with collagen-induced arthritis via the nuclear factor-κB pathway., PMID:35122384
RGS10 Reduces Lethal Influenza Infection and Associated Lung Inflammation in Mice., PMID:34912341
miR-199b-5p mediates adriamycin-induced podocyte apoptosis by inhibiting the expression of RGS10., PMID:34737809
Experimental colitis promotes sustained, sex-dependent, T-cell-associated neuroinflammation and parkinsonian neuropathology., PMID:34412704
Metabolic acidosis regulates RGS16 and G protein signaling in osteoblasts., PMID:34396788
PI3K/ NF-κB-dependent TNF-α and HDAC activities facilitate LPS-induced RGS10 suppression in pulmonary macrophages., PMID:34339853
Short stature and combined immunodeficiency associated with mutations in RGS10., PMID:34315806
Identification of a five-gene signature of the RGS gene family with prognostic value in ovarian cancer., PMID:33845140
Inhibition of regulator of G protein signaling 10, aggravates rheumatoid arthritis progression by promoting NF-κB signaling pathway., PMID:33836352
RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia., PMID:33705894
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis., PMID:33387485
A broad analysis in clinical and in vitro models on regulator of G-protein signalling 10 regulation that is associated with ovarian cancer progression and chemoresistance., PMID:33354811
Regulator of G protein signaling 10: Structure, expression and functions in cellular physiology and diseases., PMID:32882407
WGCNA reveals key gene modules regulated by the combined treatment of colon cancer with PHY906 and CPT11., PMID:32812032
Tetrandrine partially reverses multidrug resistance of human laryngeal cancer cells., PMID:32776811
RGS10 and RGS18 differentially limit platelet activation, promote platelet production, and prolong platelet survival., PMID:32542378
RGS Proteins as Critical Regulators of Motor Function and Their Implications in Parkinson's Disease., PMID:32015009
Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling., PMID:31828304
Gene-level genome-wide association analysis of suicide attempt, a preliminary study in a psychiatric Mexican population., PMID:31578828
The Presence of High Levels of Circulating Trimethylamine N-Oxide Exacerbates Central and Peripheral Inflammation and Inflammatory Hyperalgesia in Rats Following Carrageenan Injection., PMID:31489527
Maternal Choline Supplementation Alters Basal Forebrain Cholinergic Neuron Gene Expression in the Ts65Dn Mouse Model of Down Syndrome., PMID:31120189
Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias., PMID:30538250
RGS10 shapes the hemostatic response to injury through its differential effects on intracellular signaling by platelet agonists., PMID:30150297
P2X7 Receptors Mediate CO-Induced Alterations in Gene Expression in Cultured Cortical Astrocytes-Transcriptomic Study., PMID:30105670
RGS10 Regulates the Expression of Cyclooxygenase-2 and Tumor Necrosis Factor Alpha through a G Protein-Independent Mechanism., PMID:30049816
Depletion of regulator-of-G-protein signaling-10 in mice exaggerates high-fat diet-induced insulin resistance and inflammation, and this effect is mitigated by dietary green tea extract., PMID:30032988
"Disruptor" residues in the regulator of G protein signaling (RGS) R12 subfamily attenuate the inactivation of Gα subunits., PMID:29895615
The antiepileptogenic effect of low-frequency stimulation on perforant path kindling involves changes in regulators of G-protein signaling in rat., PMID:28320185
Regulator of G Protein Signaling 10 (Rgs10) Expression Is Transcriptionally Silenced in Activated Microglia by Histone Deacetylase Activity., PMID:28031332
RGS10 Negatively Regulates Platelet Activation and Thrombogenesis., PMID:27829061
The First Pilot Genome-Wide Gene-Environment Study of Depression in the Japanese Population., PMID:27529621
For research use only. Not for human or drug use.
