Catalog No.
YHA72901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys237-Leu452
Predicted molecular weight
27.29 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43615
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mitochondrial import inner membrane translocase subunit TIM44, TIMM44, MIMT44, TIM44
Endogenous interactomes of MFN1 and MFN2 provide novel insights into interorganelle communication and autophagy., PMID:39675054
A first-in-class TIMM44 blocker inhibits bladder cancer cell growth., PMID:38467612
Hepatic palmitoyl-proteomes and acyl-protein thioesterase protein proximity networks link lipid modification and mitochondria., PMID:37925639
Heart failure in patients is associated with downregulation of mitochondrial quality control genes., PMID:37403271
The mitochondrial protein TIMM44 is required for angiogenesis in vitro and in vivo., PMID:37147302
TIMM44 is a potential therapeutic target of human glioma., PMID:36438483
Super-resolution microscopy reveals the arrangement of inner membrane protein complexes in mammalian mitochondria., PMID:34313317
ALS/FTD mutations in UBQLN2 are linked to mitochondrial dysfunction through loss-of-function in mitochondrial protein import., PMID:33891006
HuR Promotes Ovarian Cancer Cell Proliferation by Regulating TIMM44 mRNA Stability., PMID:32901414
Enhanced Mitophagy Activity in Prion-Infected Cultured Cells and Prion-Infected Experimental Mice via a Pink1/Parkin-Dependent Mitophagy Pathway., PMID:32049477
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange., PMID:31618756
Resolvin D1 reduces mitochondrial damage to photoreceptors of primary retinal cells exposed to high glucose., PMID:31612492
A new mutation-independent approach to cancer therapy: Inhibiting oncogenic RAS and MYC, by targeting mitochondrial biogenesis., PMID:29080556
Effects of proton beam irradiation on mitochondrial biogenesis in a human colorectal adenocarcinoma cell line., PMID:28713989
Identification of a fluorescent small-molecule enhancer for therapeutic autophagy in colorectal cancer by targeting mitochondrial protein translocase TIM44., PMID:27849558
Read-through transcripts in normal human lung parenchyma are down-regulated in lung adenocarcinoma., PMID:27058892
Stimulatory Effects of Balanced Deep Sea Water on Mitochondrial Biogenesis and Function., PMID:26068191
Translocase of inner mitochondrial membrane 44 alters the mitochondrial fusion and fission dynamics and protects from type 2 diabetes., PMID:25749183
Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy., PMID:23255365
Diabetic retinopathy and damage to mitochondrial structure and transport machinery., PMID:22003103
Interaction of the Tim44 C-terminal domain with negatively charged phospholipids., PMID:19863062
The reducible complexity of a mitochondrial molecular machine., PMID:19717453
Altered proteome biology of cardiac mitochondria under stress conditions., PMID:18484766
Structure of the human Tim44 C-terminal domain in complex with pentaethylene glycol: ligand-bound form., PMID:18084070
Novel germline variants identified in the inner mitochondrial membrane transporter TIMM44 and their role in predisposition to oncocytic thyroid carcinomas., PMID:17088905
Crystal structure of yeast mitochondrial peripheral membrane protein Tim44p C-terminal domain., PMID:16647716
A genomewide analysis of genes for the heat shock protein 70 chaperone system in the ascidian Ciona intestinalis., PMID:16572726
Therapeutic approach for diabetic nephropathy using gene delivery of translocase of inner mitochondrial membrane 44 by reducing mitochondrial superoxide production., PMID:16510762
Gene delivery of Tim44 reduces mitochondrial superoxide production and ameliorates neointimal proliferation of injured carotid artery in diabetic rats., PMID:16186389
Functional consequences of thyroid hormone-induced changes in the mitochondrial protein import pathway., PMID:12388124
Probing the membrane topology of a subunit of the mitochondrial protein translocase, Tim44, with biotin maleimide., PMID:12054602
Rapid regulation of steroidogenesis by mitochondrial protein import., PMID:11986670
Renal gene expression in embryonic and newborn diabetic mice., PMID:11937760
The mitochondrial import machinery for preproteins., PMID:11450972
Isoform-specific localization of A-RAF in mitochondria., PMID:10848612
Genetic and structural characterization of the human mitochondrial inner membrane translocase., PMID:10339406
Characterization of the initial steps of precursor import into rat liver mitoplasts., PMID:9756630
Identification of the protein import components of the rat mitochondrial inner membrane, rTIM17, rTIM23, and rTIM44., PMID:9538267
Characterization of mammalian translocase of inner mitochondrial membrane (Tim44) isolated from diabetic newborn mouse kidney., PMID:9419343
For research use only. Not for human or drug use.
