Catalog No.
YHA72301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Tyr282-Ala387
Predicted molecular weight
39.13 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43603
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Galanin receptor type 2, GAL2-R, GALR-2, GALR2, GALNR2
The study of biodegradation of galanin and its N-terminal fragments in a model system in vitro., PMID:40045726
Effects of celastrol on the heart and liver galaninergic system expression in a mouse model of Western-type diet-induced obesity and metabolic dysfunction-associated steatotic liver disease and steatohepatitis., PMID:39968178
A new pharmacological strategy against treatment-resistant depression., PMID:39522791
Differential activation of six galanin receptors by the spexin peptide in yellowtail kingfish (Seriola lalandi)., PMID:39426688
Novel hypothalamic pathways for metabolic effects of spexin., PMID:39245191
Spexin and its receptors in the yellowtail kingfish (Seriola lalandi): identification, expression profiles and reproductive function., PMID:39207579
Exercise training and spexin ameliorate thyroid changes in obese type 2 diabetic rats: the possible interlaying mechanisms., PMID:39017682
Advances in research on spexin-mediated regulation of reproductive function in vertebrates., PMID:38915898
Spexin Diminishes Atrial Fibrillation Vulnerability by Acting on Galanin Receptor 2., PMID:38726666
Glyphosate-induced changes in the expression of galanin and GALR1, GALR2 and GALR3 receptors in the porcine small intestine wall., PMID:38632282
Enhanced neuronal survival and BDNF elevation via long-term co-activation of galanin 2 (GALR2) and neuropeptide Y1 receptors (NPY1R): potential therapeutic targets for major depressive disorder., PMID:38622072
Long-term enhancements in antidepressant efficacy and neurogenesis: Effects of intranasal co-administration of neuropeptide Y 1 receptor (NPY1R) and galanin receptor 2 (GALR2) agonists in the ventral hippocampus., PMID:38572811
Enhancement of neurogenesis and cognition through intranasal co-delivery of galanin receptor 2 (GALR2) and neuropeptide Y receptor 1 (NPY1R) agonists: a potential pharmacological strategy for cognitive dysfunctions., PMID:38549164
Role of Spexin in White Adipose Tissue Thermogenesis under Basal and Cold-Stimulated Conditions., PMID:38339044
Jaw size variation is associated with a novel craniofacial function for galanin receptor 2 in an adaptive radiation of pupfishes., PMID:37876194
Cortical spreading depolarization is a potential target for rat brain excitability modulation by Galanin., PMID:37827229
An update on galanin and spexin and their potential for the treatment of type 2 diabetes and related metabolic disorders., PMID:37714335
Spexin role in human granulosa cells physiology and PCOS: expression and negative impact on steroidogenesis and proliferation†., PMID:37658762
Exogenous GalR2-specific peptide agonist as a tool for treating myocardial ischemia/reperfusion injury., PMID:37249014
The role of spexin in energy metabolism., PMID:36914115
Decreased medial prefrontal cortex activity related to impaired novel object preference task performance following GALR2 and Y1R agonists intranasal infusion., PMID:36848750
GALR2 and Y1R agonists intranasal infusion enhanced adult ventral hippocampal neurogenesis and antidepressant-like effects involving BDNF actions., PMID:36599082
Investigating the potential of GalR2 as a drug target for neuropathic pain., PMID:36580831
Galanin Receptors (GALR1, GALR2, and GALR3) Immunoexpression in Enteric Plexuses of Colorectal Cancer Patients: Correlation with the Clinico-Pathological Parameters., PMID:36551197
Galanin N-terminal fragment (1-15) reduces alcohol seeking and alcohol relapse in rats: Involvement of mesocorticolimbic system., PMID:36076594
Levels of spexin and its receptors GALR2 and GALR3 in the hypothalamus and ovary of letrozole-induced polycystic ovary syndrome in rats., PMID:36055012
The GAL/GALR2 axis promotes the perineural invasion of salivary adenoid cystic carcinoma via epithelial-to-mesenchymal transition., PMID:36039037
Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface., PMID:35913979
Immortalized Bone Mesenchymal Stromal Cells With Inducible Galanin Expression Produce Controllable Pain Relief in Neuropathic Rats., PMID:35726855
[The anti-ischemic and antioxidant activity of the pharmacological agonist of galanin receptor GalR2 and carnosine in in vitro and in vivo model systems]., PMID:35717583
Treatment with spexin mitigates diet-induced hepatic steatosis in vivo and in vitro through activation of galanin receptor 2., PMID:35654225
Structural insights into galanin receptor signaling., PMID:35594396
Chimeric Agonist of Galanin Receptor GALR2 Reduces Heart Damage in Rats with Streptozotocin-Induced Diabetes., PMID:35527373
Galanin Regulates Myocardial Mitochondrial ROS Homeostasis and Hypertrophic Remodeling Through GalR2., PMID:35431947
Galanin Receptors (GalR1, GalR2, and GalR3) Expression in Colorectal Cancer Tissue and Correlations to the Overall Survival and Poor Prognosis of CRC Patients., PMID:35409094
Effects of Galp and alarin peptides on HPA axis gene expression and adrenal function: In vivo experiments., PMID:35275450
Galanin mediates tumor-induced immunosuppression in head and neck squamous cell carcinoma., PMID:35267186
Detection of galanin receptors in the spinal cord in experimental autoimmune encephalomyelitis., PMID:35147137
Spexin Promotes the Proliferation and Differentiation of C2C12 Cells In Vitro-The Effect of Exercise on SPX and SPX Receptor Expression in Skeletal Muscle In Vivo., PMID:35052420
Baicalin protects against insulin resistance and metabolic dysfunction through activation of GALR2/GLUT4 signaling., PMID:34923235
Modified N-Terminal Fragments of Galanin: Cardioprotective Properties and Mechanisms of Action., PMID:34903156
Galanin (1-15) Enhances the Behavioral Effects of Fluoxetine in the Olfactory Bulbectomy Rat, Suggesting a New Augmentation Strategy in Depression., PMID:34891163
Identification of Molecular Markers of Clozapine Action in Ketamine-Induced Cognitive Impairment: A GPCR Signaling PathwayFinder Study., PMID:34830086
Galanin(1-15) Potentiates the Antidepressant-like Effects Induced by Escitalopram in a Rat Model of Depression., PMID:34639188
Theoretical investigation of selective ligand binding mode of galanin receptors., PMID:34632940
Serotonin Heteroreceptor Complexes and Their Integration of Signals in Neurons and Astroglia-Relevance for Mental Diseases., PMID:34440670
Involvement of galanin and galanin receptor 2 in a mouse model of allergic rhinitis., PMID:34412988
Time-restricted feeding prevents metabolic diseases through the regulation of galanin/GALR1 expression in the hypothalamus of mice., PMID:34370270
Mouse Spexin: (II) Functional Role as a Satiety Factor inhibiting Food Intake by Regulatory Actions Within the Hypothalamus., PMID:34276562
Mouse Spexin: (I) NMR Solution Structure, Docking Models for Receptor Binding, and Histological Expression at Tissue Level., PMID:34276561
For research use only. Not for human or drug use.
