Catalog No.
YHA71201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu33-Glu175
Predicted molecular weight
18.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43567
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3 ubiquitin-protein ligase RNF13, 2.3.2.27, RING finger protein 13, RNF13, RZF
RNF13 variants L311S and L312P associated with developmental epileptic encephalopathy alter dendritic organization in hippocampal neurons., PMID:40276023
[Genetic analysis of a pedigree affected with Intellectual disability due to variants of two different genes]., PMID:39528279
RNF13 protects neurons against ischemia-reperfusion injury via stabilizing p62-mediated Nrf2/HO-1 signaling pathway., PMID:39511649
AP-1 contributes to endosomal targeting of the ubiquitin ligase RNF13 via a secondary and novel non-canonical binding motif., PMID:39206621
E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP-1 Proteasomal Degradation., PMID:39031743
Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases., PMID:38785043
The mouse retinal pigment epithelium mounts an innate immune defense response following retinal detachment., PMID:38528525
Galectin 9 restricts viral replication in teleost via autophagy-antiviral pathway and polarizes M2 macrophages for anti-inflammatory response: New insights into functional properties of fish Galectin-9 from Planiliza haematocheilus., PMID:37858785
RING finger protein 13 protects against nonalcoholic steatohepatitis by targeting STING-relayed signaling pathways., PMID:37857628
RNF13 protects against pathological cardiac hypertrophy through p62-NRF2 pathway., PMID:37852547
Heterozygous gain of function variants in a critical region of RNF13 cause congenital microcephaly, epileptic encephalopathy, blindness, and failure to thrive., PMID:37668308
Molecular Characterization of Esophageal Squamous Cell Carcinoma Using Quantitative Proteomics., PMID:37444412
Recurrent PAK2 rearrangements in poroma with folliculo-sebaceous differentiation., PMID:37199682
Identification of RNF13 as cause of recessively inherited ALS in a multi-case pedigree., PMID:35879052
Crosstalk between the innate immune system and selective autophagy in hepatitis B virus infection., PMID:35380913
From Drosophila to Human: Biological Function of E3 Ligase Godzilla and Its Role in Disease., PMID:35159190
Galectin-9 restricts hepatitis B virus replication via p62/SQSTM1-mediated selective autophagy of viral core proteins., PMID:35087074
RNF13 Dileucine Motif Variants L311S and L312P Interfere with Endosomal Localization and AP-3 Complex Association., PMID:34831286
Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2., PMID:34465340
MiR-32-3p Regulates Myocardial Injury Induced by Microembolism and Microvascular Obstruction by Targeting RNF13 to Regulate the Stability of Atherosclerotic Plaques., PMID:34185281
Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2., PMID:33714261
Integrated differential DNA methylation and gene expression of formalin-fixed paraffin-embedded uveal melanoma specimens identifies genes associated with early metastasis and poor prognosis., PMID:33387485
The Regulation of circRNA RNF13/miRNA-1224-5p Axis Promotes the Malignant Evolution in Acute Myeloid Leukemia., PMID:33083473
β-Elemene Inhibits the Proliferation and Migration of Human Glioblastoma Cell Lines via Suppressing Ring Finger Protein 135., PMID:32953408
Silencing RNF13 Alleviates Parkinson's Disease - Like Problems in Mouse Models by Regulating the Endoplasmic Reticulum Stress-Mediated IRE1α-TRAF2-ASK1-JNK Pathway., PMID:32617872
The effects of environmental stressors on candidate aging associated genes., PMID:32344118
Heterozygous RNF13 Gain-of-Function Variants Are Associated with Congenital Microcephaly, Epileptic Encephalopathy, Blindness, and Failure to Thrive., PMID:30595371
Genomic Analysis of Pigmented Epithelioid Melanocytomas Reveals Recurrent Alterations in PRKAR1A, and PRKCA Genes., PMID:28796000
IRE1α Signaling Pathways Involved in Mammalian Cell Fate Determination., PMID:26910807
Enhanced metastasis in RNF13 knockout mice is mediated by a reduction in GM-CSF levels., PMID:26197965
Accelerated regeneration of the skeletal muscle in RNF13-knockout mice is mediated by macrophage-secreted IL-4/IL-6., PMID:24563216
Temporal profile of the vascular anatomy evaluated by 9.4-T magnetic resonance angiography and histopathological analysis in mice lacking RNF213: a susceptibility gene for moyamoya disease., PMID:24440776
Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization., PMID:24387786
RNF13 protein regulates endoplasmic reticulum stress induced apoptosis in dopaminergic SH-SY5Y cells by enhancing IRE1α stability., PMID:24303962
RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1α)/c-Jun NH2-terminal kinase pathway., PMID:23378536
E3 ubiquitin ligase RNF13 involves spatial learning and assembly of the SNARE complex., PMID:22890573
RNF13: an emerging RING finger ubiquitin ligase important in cell proliferation., PMID:21078127
Trafficking and proteolytic processing of RNF13, a model PA-TM-RING family endosomal membrane ubiquitin ligase., PMID:21078126
Nuclear targeting of an endosomal E3 ubiquitin ligase., PMID:20230530
The myostatin-induced E3 ubiquitin ligase RNF13 negatively regulates the proliferation of chicken myoblasts., PMID:20015074
The PA-TM-RING protein RING finger protein 13 is an endosomal integral membrane E3 ubiquitin ligase whose RING finger domain is released to the cytoplasm by proteolysis., PMID:19292867
RNF13: a novel RING-type ubiquitin ligase over-expressed in pancreatic cancer., PMID:18794910
For research use only. Not for human or drug use.
