Catalog No.
YHA62301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Trp161-Pro418
Predicted molecular weight
31.28 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43283
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mitogen-activated protein kinase kinase kinase 13, 2.7.11.25, Leucine zipper-bearing kinase, Mixed lineage kinase, MLK, MAP3K13, LZK
Nitrate activates an MKK3-dependent MAPK module via NLP transcription factors in Arabidopsis., PMID:39962336
Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors., PMID:39933019
Exploring MAP3K genes in gastric cancer: biomarkers, tumor microenvironment dynamics, and chemotherapy resistance., PMID:39901302
The MKK3 module integrates nitrate and light signals to modulate secondary dormancy in Arabidopsis thaliana., PMID:39298469
Association of Germline Variation in Driver Genes with Breast Cancer Risk in Chilean Population., PMID:38003265
Multi-staged gene expression profiling reveals potential genes and the critical pathways in kidney cancer., PMID:35508649
A Critical Role for DLK and LZK in Axonal Repair in the Mammalian Spinal Cord., PMID:35361703
Clinical significance of mitogen-activated protein kinase kinase kinases in hepatitis B virus -related hepatocellular carcinoma and underlying mechanism exploration., PMID:35311629
Head and Neck Malignant Paragangliomas: Experience from a Single Institution., PMID:34654328
LINC01287 facilitates proliferation, migration, invasion and EMT of colon cancer cells via miR-4500/MAP3K13 pathway., PMID:34229645
New Therapeutic Opportunities for the Treatment of Squamous Cell Carcinomas: A Focus on Novel Driver Kinases., PMID:33799513
Weighted gene co-expression network analysis of the salt-responsive transcriptomes reveals novel hub genes in green halophytic microalgae Dunaliella salina., PMID:33452393
Epigenomic, Transcriptomic, and Protective Effect of Carotenoid Fucoxanthin in High Glucose-Induced Oxidative Stress in Mes13 Kidney Mesangial Cells., PMID:33448797
lnc-MAP3K13-7:1 Inhibits Ovarian GC Proliferation in PCOS via DNMT1 Downregulation-Mediated CDKN1A Promoter Hypomethylation., PMID:33212300
Impact of genetic alterations on outcomes of patients with stage I nonsmall cell lung cancer: An analysis of the cancer genome atlas data., PMID:32857918
Identification of prognostic alternative splicing signatures in hepatitis B or/and C viruses related hepatocellular carcinoma., PMID:32525024
A novel neurodegenerative spectrum disorder in patients with MLKL deficiency., PMID:32358523
Small RNA sequencing of pectoral muscle tissue reveals microRNA-mediated gene modulation in chicken muscle growth., PMID:31957920
Multitasking: Dual Leucine Zipper-Bearing Kinases in Neuronal Development and Stress Management., PMID:31590586
Expression of receptor interacting protein 3 and mixed lineage kinase domain-like protein-key proteins in necroptosis is upregulated in ulcerative colitis., PMID:31431023
The MAP3K13-TRIM25-FBXW7α axis affects c-Myc protein stability and tumor development., PMID:31186535
Bridging genomics and phenomics of gastric carcinoma., PMID:30801717
Leucine Zipper-Bearing Kinase Is a Critical Regulator of Astrocyte Reactivity in the Adult Mammalian CNS., PMID:29590625
Survival of Head and Neck Cancer Cells Relies upon LZK Kinase-Mediated Stabilization of Mutant p53., PMID:28760853
Endosulfan inducing apoptosis and necroptosis through activation RIPK signaling pathway in human umbilical vascular endothelial cells., PMID:27709431
Leucine Zipper-bearing Kinase promotes axon growth in mammalian central nervous system neurons., PMID:27511108
Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase., PMID:27100796
microRNA-206 impairs c-Myc-driven cancer in a synthetic lethal manner by directly inhibiting MAP3K13., PMID:26918941
Can Genetic Analysis of Putative Blood Alzheimer's Disease Biomarkers Lead to Identification of Susceptibility Loci?, PMID:26625115
Regulation of DLK-1 kinase activity by calcium-mediated dissociation from an inhibitory isoform., PMID:23141066
The landscape of cancer genes and mutational processes in breast cancer., PMID:22722201
Genetic modifiers of the severity of sickle cell anemia identified through a genome-wide association study., PMID:20029952
Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth., PMID:19808064
[Antisense regulation of human gene MAP3K13: true phenomenon or artifact]., PMID:18856057
Mixed lineage kinase LZK and antioxidant protein-1 activate NF-kappaB synergistically., PMID:12492477
Genomic organization and fine-mapping of the human leucine zipper-bearing kinase (LZK) gene., PMID:12186766
Mixed lineage kinase LZK forms a functional signaling complex with JIP-1, a scaffold protein of the c-Jun NH(2)-terminal kinase pathway., PMID:11726277
The MLK family mediates c-Jun N-terminal kinase activation in neuronal apoptosis., PMID:11416147
Identification and characterization of functional domains in a mixed lineage kinase LZK., PMID:11163770
Identification of structural and functional domains in mixed lineage kinase dual leucine zipper-bearing kinase required for complex formation and stress-activated protein kinase activation., PMID:10702297
Molecular cloning and functional expression of a cDNA encoding a new member of mixed lineage protein kinase from human brain., PMID:9353328
For research use only. Not for human or drug use.
