Catalog No.
YHA61301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr119-Ala195
Predicted molecular weight
37.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O43251
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
RNA binding protein fox-1 homolog 2, Fox-1 homolog B, Hexaribonucleotide-binding protein 2, RNA-binding motif protein 9, RNA-binding protein 9, Repressor of tamoxifen transcriptional activity, RBFOX2, FOX2, HRNBP2, RBM9, RTA
Identify the co-expressed genes of hypertensive nephropathy and diabetic nephropathy., PMID:40461634
RBFOX2 induces osteogenic differentiation by Jph2 expression in MC3T3-E1 preosteoblast cells., PMID:40232550
Alternative splicing of the Snap23 microexon is regulated by MBNL, QKI, and RBFOX2 in a tissue-specific manner and is altered in striated muscle diseases., PMID:40207498
Clusters of deep intronic RbFox motifs embedded in large assembly of splicing regulators sequences regulate alternative splicing., PMID:40166205
Pervasive RNA-binding protein enrichment on TAD boundaries regulates TAD organization., PMID:39777468
Upregulation of WDR4 mediated by RBFOX2 promotes laryngeal cancer progression through the WDR4/m7G/lncRNA ZFAS1/RBFOX2 axis., PMID:39774908
RBFOX2 as a regulatory linchpin in cancer: insights from a comprehensive review of its roles in tumorigenesis., PMID:39553227
Cell-Type-Specific Splicing of Transcription Regulators and Ptbp1 by Rbfox1/2/3 in the Developing Neocortex., PMID:39532536
Alternative splicing of PBRM1 mediates resistance to PD-1 blockade therapy in renal cancer., PMID:39375538
RNA binding protein with multiple splicing (RBPMS) promotes contractile phenotype splicing in human embryonic stem cell-derived vascular smooth muscle cells., PMID:39248180
A novel m6A reader RBFOX2 expression is increased in oral squamous cell carcinoma and promotes tumorigenesis., PMID:39244024
RNA splicing factor RBFOX2 is a key factor in the progression of cancer and cardiomyopathy., PMID:39243148
Gastrin-related circRNA_0017065 promotes the proliferation and metastasis of colorectal cancer through the miR-3174/RBFOX2 axis., PMID:39198845
High-sensitivity in situ capture of endogenous RNA-protein interactions in fixed cells and primary tissues., PMID:39152130
Regulatory role of lncH19 in RAC1 alternative splicing: implication for RAC1B expression in colorectal cancer., PMID:39098911
Mechanism of LncRNA Gm2044 in germ cell development., PMID:39027044
Enhanced isradipine sensitivity in vascular smooth muscle cells due to hypoxia-induced Cav1.2 splicing and RbFox1/Fox2 downregulation., PMID:38794806
The comprehensive roles of lncRNA FAM99A/FAM99B in hepatocellular carcinoma: Expressions, regulatory mechanisms and functional pathway analysis., PMID:38740325
NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion., PMID:38547058
RNA-Binding Proteins in Cardiomyopathies., PMID:38535111
RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing., PMID:38114498
Modulation of insulin secretion by RBFOX2-mediated alternative splicing., PMID:38007492
Improved discovery of RNA-binding protein binding sites in eCLIP data using DEWSeq., PMID:37962298
[Loss of RBFOX2 inhibits meiotic initiation in male mice]., PMID:37877394
FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing., PMID:37822160
FLARE: a fast and flexible workflow for identifying RNA editing foci., PMID:37784060
RBFOX2 recognizes N6-methyladenosine to suppress transcription and block myeloid leukaemia differentiation., PMID:37640841
Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators., PMID:37548402
Dysregulated Rbfox2 produces aberrant splicing of CaV1.2 calcium channel in diabetes-induced cardiac hypertrophy., PMID:37415128
RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer., PMID:37264873
Alternative Splicing Outcomes Across an RNA-Binding Protein Concentration Gradient., PMID:37230319
Contribution of Previously Unrecognized RNA Splice-Altering Variants to Congenital Heart Disease., PMID:37165897
Improved analysis of (e)CLIP data with RCRUNCH yields a compendium of RNA-binding protein binding sites and motifs., PMID:37069586
RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer., PMID:36949200
Detection and targeting of splicing deregulation in pediatric acute myeloid leukemia stem cells., PMID:36889320
NF-YAl drives EMT in Claudinlow tumours., PMID:36707502
Suppression of RBFox2 by Multiple MiRNAs in Pressure Overload-Induced Heart Failure., PMID:36674797
Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice., PMID:36536133
Characterization of alternative mRNA splicing in cultured cell populations representing progressive stages of human fetal kidney development., PMID:36380228
RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function., PMID:36367103
LncRNA ZFAS1 promotes laryngeal cancer progression through RBFOX2-mediated MENA alternative splicing., PMID:36336961
Intrinsic myocardial defects underlie an Rbfox-deficient zebrafish model of hypoplastic left heart syndrome., PMID:36198703
CircRAPGEF5 interacts with RBFOX2 to confer ferroptosis resistance by modulating alternative splicing of TFRC in endometrial cancer., PMID:36182807
Leveraging big data of immune checkpoint blockade response identifies novel potential targets., PMID:36055464
Myocardin regulates exon usage in smooth muscle cells through induction of splicing regulatory factors., PMID:35913515
Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis., PMID:35778567
RBFOX2-regulated TEAD1 alternative splicing plays a pivotal role in Hippo-YAP signaling., PMID:35699208
LncRNA MIAT Promotes Spinal Cord Injury Recovery in Rats by Regulating RBFOX2-Mediated Alternative Splicing of MCL-1., PMID:35641779
Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies., PMID:35404107
Evolution Increases Primates Brain Complexity Extending RbFOX1 Splicing Activity to LSD1 Modulation., PMID:35351830
For research use only. Not for human or drug use.
