Catalog No.
YHA48601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser96-Leu395
Predicted molecular weight
35.72 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15297
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein phosphatase 1D, 3.1.3.16, Protein phosphatase 2C isoform delta, PP2C-delta, Protein phosphatase magnesium-dependent 1 delta, p53-induced protein phosphatase 1, PPM1D, WIP1
Targeting NSCLC drug resistance: Systems biology insights into the MALAT1/miR-145-5p axis and Wip1 in regulating ferroptosis and apoptosis., PMID:40425041
Identifying prognostic targets in metastatic prostate cancer beyond AR., PMID:40405591
Next-generation sequencing identifies the presence of protein phosphatase 1D, PPM1D, as a potential biomarker of resistance to PARP inhibition in metastatic castration-resistant prostate cancer., PMID:40400994
Gain-of-function PPM1D mutations attenuate ischemic stroke., PMID:40399534
Gain of chromosome 17 is an early genetic abnormality in neuroblastoma with PPM1D emerging as a strong candidate oncogene driving tumor progression., PMID:40320038
Targeted inhibition of WIP1 and histone H3K27 demethylase activity synergistically suppresses neuroblastoma growth., PMID:40253363
Impact of Clonal Hematopoiesis on Solid Tumor Progression Following Radiation Therapy., PMID:40249883
Cell confluency affects p53 dynamics in response to DNA damage., PMID:40202833
Clonal Evolution of PPM1D Mutations in the Spectrum of Myeloid Disorders., PMID:40162927
PPM1D ameliorates Alzheimer's disease by promoting mitophagy., PMID:40090398
The role of the PPM1D gene in tumor pathogenesis., PMID:40045720
Wip1 phosphatase activator QGC-8-52 specifically sensitizes p53-negative cancer cells to chemotherapy while protecting normal cells., PMID:39787991
Molecular Profiling of Sinonasal Adenoid Cystic Carcinoma: Canonical and Noncanonical Gene Fusions and Mutation., PMID:39760648
Dual-action kinase inhibitors influence p38α MAP kinase dephosphorylation., PMID:39739785
PP2C phosphatases-terminators of suicidal thoughts., PMID:39702569
PPM1D/Wip1 is amplified, overexpressed, and mutated in human non-Hodgkin's lymphomas., PMID:39489796
Clonal hematopoiesis in cardiovascular aging: Insights from the verona heart study., PMID:39460851
Distinct landscape and clinical implications of therapy-related clonal hematopoiesis., PMID:39352380
Clonal landscape and clinical outcomes of telomere biology disorders: somatic rescue and cancer mutations., PMID:39316766
PPM1D activity promotes cellular transformation by preventing senescence and cell death., PMID:39237765
Alternating binding and p97-mediated dissociation of SDS22 and I3 recycles active PP1 between holophosphatases., PMID:39207734
Rising Prevalence of Low-Frequency PPM1D Gene Mutations after Second HDCT in Multiple Myeloma., PMID:39194701
Value and limitations of targeted next-generation sequencing in idiopathic hypereosinophilia: an integrative diagnostic tool in challenging cases., PMID:39042228
Crystal structure and mechanistic studies of the PPM1D serine/threonine phosphatase catalytic domain., PMID:39002674
WIP1-mediated regulation of p38 MAPK signaling attenuates pyroptosis in sepsis-associated acute kidney injury., PMID:38943814
Significance of Ribonucleoside-diphosphate Reductase Subunit M2 in Lung Adenocarcinoma., PMID:38920074
SOD1 is a synthetic-lethal target in PPM1D-mutant leukemia cells., PMID:38896450
Identification of Small Molecule Inhibitors of PPM1D Using a Novel Drug Discovery Platform., PMID:38826457
Clonal hematopoiesis-derived therapy-related myeloid neoplasms after autologous hematopoietic stem cell transplant for lymphoid and non-lymphoid disorders., PMID:38684821
Association of PARP inhibitor treatment on the prevalence and progression of clonal hematopoiesis in patients with advanced prostate cancer., PMID:38641986
Dynamics of clonal hematopoiesis under DNA-damaging treatment in patients with ovarian cancer., PMID:38637689
Clonal Hematopoiesis and Therapy-Related Myeloid Neoplasms After Autologous Transplant for Hodgkin Lymphoma., PMID:38635938
The crossroads of cancer therapies and clonal hematopoiesis., PMID:38403501
[Analysis of CHIP-Related Mutation and Risk of Cardio-Cerebrovasculars Events in Patients with Myeloproliferative Neoplasms]., PMID:38387920
Clonal Hematopoiesis of Indeterminate Potential Is Associated with Current Smoking Status and History of Exacerbation in Patients with Chronic Obstructive Pulmonary Disease., PMID:38320547
The Development and Application of Biophysical Assays for Evaluating Ternary Complex Formation Induced by Proteolysis Targeting Chimeras (PROTACS)., PMID:38284532
AFB1 Triggers Lipid Metabolism Disorders through the PI3K/Akt Pathway and Mediates Apoptosis Leading to Hepatotoxicity., PMID:38201191
Low-Frequency PPM1D Gene Mutations Affect Treatment Response to CD19-Targeted CAR T-Cell Therapy in Large B-Cell Lymphoma., PMID:38132396
PPM1D inhibition may allow us to WIP leukemia., PMID:38095924
Systematic analysis of variants escaping nonsense-mediated decay uncovers candidate Mendelian diseases., PMID:38091987
Clinicopathologic and genetic analysis of invasive breast carcinomas in women with germline CHEK2 variants., PMID:38091153
Temporal Dynamic Regulation of Autophagy and Senescence Induction in Response to Radiation Exposure., PMID:37902247
Ppm1d truncating mutations promote the development of genotoxic stress-induced AML., PMID:37709843
SOD1 is a synthetic lethal target in PPM1D-mutant leukemia cells., PMID:37693622
PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy., PMID:37595362
Proteomics and phosphoproteomics profiling in glutamatergic neurons and microglia in an iPSC model of Jansen de Vries Syndrome., PMID:37461463
miR-16-5p enhances sensitivity to RG7388 through targeting PPM1D expression (WIP1) in Childhood Acute Lymphoblastic Leukemia., PMID:37457129
Clonal hematopoiesis with DNMT3A and PPM1D mutations impairs regeneration in autologous stem cell transplant recipients., PMID:37381752
A Case Study on PPM1D and 9 Other Shared Germline Alterations in a Family., PMID:37378944
Wip1 regulates wound healing by affecting activities of keratinocytes and endothelial cells through ATM-p53 and mTOR signaling., PMID:37357059
For research use only. Not for human or drug use.
