Catalog No.
YHA32801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu332-Pro429
Predicted molecular weight
39.23 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14863
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Probable proton-coupled zinc antiporter SLC30A4, Solute carrier family 30 member 4, Zinc transporter 4, ZnT-4, SLC30A4, ZNT4
Proteomics analysis in rats reveals convergent mechanisms between major depressive disorder and dietary zinc deficiency., PMID:39623245
SLC30A4-AS1 Mediates the Senescence of Periodontal Ligament Stem Cells in Inflammatory Environments via the Alternative Splicing of TP53BP1., PMID:39572253
Cryo-EM structures of the zinc transporters ZnT3 and ZnT4 provide insights into their transport mechanisms., PMID:39474773
Zinc pre-exposure improves Zn resistance by demethylation of metallothionein 2 and transcription regulation of zinc-regulatory genes in zebrafish ZF4 cells., PMID:37352751
Slc39a4 in the small intestine predicts zinc absorption and utilization: a comprehensive analysis of zinc transporter expression in response to diets of varied zinc content in young mice., PMID:34843931
The Roles of ZnT1 and ZnT4 in Glucose-Stimulated Zinc Secretion in Prostate Epithelial Cells., PMID:33140261
Comprehensive analysis of the expression of SLC30A family genes and prognosis in human gastric cancer., PMID:33110097
MicroRNA-30a regulates acute cerebral ischemia-induced blood-brain barrier damage through ZnT4/zinc pathway., PMID:32501158
Role of miR-452-5p in the tumorigenesis of prostate cancer: A study based on the Cancer Genome Atl(TCGA), Gene Expression Omnibus (GEO), and bioinformatics analysis., PMID:29559248
IL-4 Induces Metallothionein 3- and SLC30A4-Dependent Increase in Intracellular Zn(2+) that Promotes Pathogen Persistence in Macrophages., PMID:27653687
Metallothionein and Zinc Transporter Expression in Circulating Human Blood Cells as Biomarkers of Zinc Status: a Systematic Review., PMID:27422508
Obesity and age-related alterations in the gene expression of zinc-transporter proteins in the human brain., PMID:27300264
ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation., PMID:26538236
Zinc deficiency mediates alcohol-induced apoptotic cell death in the liver of rats through activating ER and mitochondrial cell death pathways., PMID:25767260
Regulation of intracellular Zn homeostasis in two intestinal epithelial cell models at various maturation time points., PMID:25757458
Identification of novel long non-coding RNAs in clear cell renal cell carcinoma., PMID:25685243
Changes of the mRNA expression pattern of Zn transporters: a probable mechanism for cadmium retention and zinc redistribution in the suckling rat tissues., PMID:25653005
Granulocyte macrophage-colony stimulating factor induced Zn sequestration enhances macrophage superoxide and limits intracellular pathogen survival., PMID:24138881
Oocyte-cumulus cell interactions regulate free intracellular zinc in mouse oocytes., PMID:23404848
Zinc-dependent lysosomal enlargement in TRPML1-deficient cells involves MTF-1 transcription factor and ZnT4 (Slc30a4) transporter., PMID:23368743
ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cells., PMID:22621784
Zinc transporter mRNA levels in Alzheimer's disease postmortem brain., PMID:22349685
Apical localization of zinc transporter ZnT4 in human airway epithelial cells and its loss in a murine model of allergic airway inflammation., PMID:22254085
Coordinate expression and localization of iron and zinc transporters explain iron-zinc interactions during uptake in Caco-2 cells: implications for iron uptake at the enterocyte., PMID:22137264
Lack of association of polymorphic variants of genes encoding zinc transporters with the risk of orofacial cleft-affected pregnancies., PMID:21478106
Rapamycin suppresses mossy fiber sprouting but not seizure frequency in a mouse model of temporal lobe epilepsy., PMID:21307269
Dynamic pattern of gene expression of ZnT-4, caspase-3, LC3, and PRG-3 in rat cerebral cortex following flurothyl-induced recurrent neonatal seizures., PMID:21286846
Colitis locus on chromosome 2 impacting the severity of early-onset disease in mice deficient in GPX1 and GPX2., PMID:20872835
The role of survivin and Bcl-2 in zinc-induced apoptosis in prostate cancer cells., PMID:20822926
Effects of forced running exercise on cognitive function and its relation to zinc homeostasis-related gene expression in rat hippocampus., PMID:20703826
Alterations of zinc transporter proteins ZnT-1, ZnT-4 and ZnT-6 in preclinical Alzheimer's disease brain., PMID:19371353
Zinc deficiency mediates alcohol-induced alveolar epithelial and macrophage dysfunction in rats., PMID:19109243
Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain., PMID:18639746
The increase in zinc levels and upregulation of zinc transporters are mediated by nitric oxide in the cerebral cortex after transient ischemia in the rat., PMID:18289514
Intracellular zinc homeostasis in leukocyte subsets is regulated by different expression of zinc exporters ZnT-1 to ZnT-9., PMID:17971500
Differential expression of intestinal membrane transporters in cholera patients., PMID:17575980
Immunohistochemical analysis of ZnT1, 4, 5, 6, and 7 in the mouse gastrointestinal tract., PMID:17101726
Identification of a mutation in SLC30A2 (ZnT-2) in women with low milk zinc concentration that results in transient neonatal zinc deficiency., PMID:17065149
Zinc transporters in the mouse placenta show a coordinated regulatory response to changes in dietary zinc intake., PMID:16914197
Zinc and its specific transporters as potential targets in airway disease., PMID:16719771
Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain., PMID:16580781
Induction of zinc transporters by forskolin in human trophoblast BeWo cells., PMID:16503475
Increased abundance of labile intracellular zinc during cell proliferation was due to increased retention of extracellular zinc in 3T3 cells., PMID:16443356
Homeostatic regulation of zinc transporters in the human small intestine by dietary zinc supplementation., PMID:15753530
Abundant expression of zinc transporters in Bergman glia of mouse cerebellum., PMID:15607832
Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation., PMID:15187159
Differential expression of hZnT-4 in human prostate tissues., PMID:14968438
Mutation analysis of the zinc transporter gene SLC30A4 reveals no association with periodic catatonia on chromosome 15q15., PMID:14628196
Zn transporter levels and localization change throughout lactation in rat mammary gland and are regulated by Zn in mammary cells., PMID:14608047
Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer., PMID:12955079
For research use only. Not for human or drug use.
