Catalog No.
YHA28301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
[Phe49-Arg73] & [Ser117-Pro139] & [Thr196-Lys213]
Predicted molecular weight
23.35 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14735
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CDP-diacylglycerol--inositol 3-phosphatidyltransferase, 2.7.8.11, Phosphatidylinositol synthase, PI synthase, PtdIns synthase, CDIPT, PIS, PIS1
Comprehensive Molecular and Genomic Analysis of NCI-MATCH Subprotocol Y: Capivasertib in Patients With an AKT1 E17K-Mutated Tumor., PMID:40153687
Prediction of Weight Loss to Decrease the Risk for Type 2 Diabetes Using Multidimensional Data in Filipino Americans: Secondary Analysis., PMID:37040172
Ferrostatin-1 modulates dysregulated kidney lipids in acute kidney injury., PMID:35152438
Autophagosome formation in relation to the endoplasmic reticulum., PMID:33087127
De novo phosphoinositide synthesis in zebrafish is required for triad formation but not essential for myogenesis., PMID:32804943
Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity., PMID:31897490
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death., PMID:31204559
Analysis of miRNA-seq in the liver of common carp (Cyprinus carpio L.) in response to different environmental temperatures., PMID:30443850
Dysregulated phosphatidylinositol signaling promotes endoplasmic-reticulum-stress-mediated intestinal mucosal injury and inflammation in zebrafish., PMID:24135483
Phosphatidylinositol synthase is required for lens structural integrity and photoreceptor cell survival in the zebrafish eye., PMID:21722635
Lack of de novo phosphatidylinositol synthesis leads to endoplasmic reticulum stress and hepatic steatosis in cdipt-deficient zebrafish., PMID:21488074
Clinical significance of phosphatidyl inositol synthase overexpression in oral cancer., PMID:20426864
Novel molecular targets of smokeless tobacco (khaini) in cell culture from oral hyperplasia., PMID:16730401
Alpha-1 antitrypsin deficiency in Italy: regional differences of the PIS and PIZ deficiency alleles., PMID:16312203
Resveratrol inhibits polyphosphoinositide metabolism in activated platelets., PMID:16051184
Trimetazidine effect on phospholipid synthesis in ventricular myocytes: consequences in alpha-adrenergic signaling., PMID:12588630
Cytostatic effect of inostamycin, an inhibitor of cytidine 5'-diphosphate 1,2-diacyl-sn-glycerol (CDP-DG): inositol transferase, on oral squamous cell carcinoma cell lines., PMID:11448100
myo-[3H]-inositol loaded erythrocytes and white ghosts: two models to investigate the phosphatidylinositol synthesis in human red cells., PMID:10575355
2-Chloroadenosine reverses hyperglycemia-induced inhibition of phosphoinositide synthesis in cultured human retinal pigment epithelial cells and prevents reduced nerve conduction velocity in diabetic rats., PMID:10421220
Localization of mRNAs for CDP-diacylglycerol synthase and phosphatidylinositol synthase in the brain and retina of developing and adult rats., PMID:9733908
The role of CDP-diacylglycerol synthetase and phosphatidylinositol synthase activity levels in the regulation of cellular phosphatidylinositol content., PMID:9407135
Phosphatidylinositol synthase from mammalian tissues., PMID:9370331
Inhibition of G1 cyclin expression in normal rat kidney cells by inostamycin, a phosphatidylinositol synthesis inhibitor., PMID:9010759
Molecular cloning of rat phosphatidylinositol synthase cDNA by functional complementation of the yeast Saccharomyces cerevisiae pis mutation., PMID:8804431
Identification of rat liver phosphatidylinositol synthase as a 21 kDa protein., PMID:7998949
Neurotransmitter-stimulated breakdown of endogenous polyphosphoinositides in post mortem human brain., PMID:7915914
Purification and characterization of phosphatidylinositol synthase from human placenta., PMID:8110188
Synthesis and evaluation of 3-modified 1D-myo-inositols as inhibitors and substrates of phosphatidylinositol synthase and inhibitors of myo-inositol uptake by cells., PMID:8246231
Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture., PMID:8415767
Organization of the phosphoinositide cycle. Assessment of inositol transferase activity in purified plasma membranes., PMID:8382477
Evidence of a role for phosphatidylinositol synthesis in human amnion cell proliferation., PMID:1335765
Inhibition of phosphatidylinositol synthase by glucose in human retinal pigment epithelial cells., PMID:1314495
Unimpaired formation of hormone-stimulated inositol trisphosphate in human mesangial cells under hyperglycemic conditions., PMID:1312360
CMP activates reversal of phosphatidylinositol synthase and base exchange by distinct mechanisms in rat pituitary GH3 cells., PMID:2176479
Phosphoinositide metabolism in cultured glioma and neuroblastoma cells: subcellular distribution of enzymes indicate incomplete turnover at the plasma membrane., PMID:2156558
Developmental patterns in rat brain of phosphatidylinositol synthetic enzymes and phosphatidylinositol transfer protein., PMID:2557926
Characterization of a salt-extractable phosphatidylinositol synthase from rat pituitary-tumour membranes., PMID:2539091
In vitro and ex vivo effects of antidepressants on rat brain membrane-bound phosphatidylinositol synthetase activity., PMID:2845289
Regulation by phosphatidylinositol of rat pituitary plasma membrane and endoplasmic reticulum phosphatidylinositol synthase activities. A mechanism for activation of phosphoinositide resynthesis during cell stimulation., PMID:3032971
Independent phosphatidylinositol synthesis in pituitary plasma membrane and endoplasmic reticulum., PMID:3029593
Early effect of myo-inositol deficiency on phosphatidylinositol metabolism in rat liver., PMID:3026487
Comparison of the enzyme activities of phosphatidylcholine, phosphatidylglycerol and phosphatidylinositol synthesis in freshly isolated type II pneumocytes and whole lung from the adult rat., PMID:3013315
Phosphatidylinositol:myo-inositol exchange activity in intact nerve endings: substrate and cofactor dependence, nucleotide specificity, and effect on synaptosomal handling of myo-inositol., PMID:3005502
Enzymes of phospholipid metabolism in rat pancreatic islets: subcellular distribution and the effect of glucose and calcium., PMID:3023405
Purification of phosphatidylinositol synthetase from rat brain by CDP-diacylglycerol affinity chromatography and properties of the purified enzyme., PMID:2981098
Inhibition of platelet phosphatidylinositol synthetase by an analog of CDP-diacylglycerol., PMID:6093888
Subcellular distribution of the enzymes related to phospholipid synthesis in developing rat lung., PMID:6305424
Effect of unsaturated fatty acids and Ca2+ on phosphatidylinositol synthesis and breakdown., PMID:6281246
Topography of glycerolipid synthetic enzymes. Synthesis of phosphatidylserine, phosphatidylinositol and glycerolipid intermediates occurs on the cytoplasmic surface of rat liver microsomal vesicles., PMID:6271231
Enzymes of phospholipid synthesis: axonal versus Schwann cell distribution., PMID:6244061
For research use only. Not for human or drug use.
