Catalog No.
YHA27601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Gln170
Predicted molecular weight
21.54 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14717
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
tRNA (cytosine(38)-C(5))-methyltransferase, 2.1.1.204, DNA (cytosine-5)-methyltransferase-like protein 2, Dnmt2, DNA methyltransferase homolog HsaIIP, DNA MTase homolog HsaIIP, M.HsaIIP, PuMet, TRDMT1, DNMT2
HuMSCs-derived exosomal YBX1 participates in oxidative damage repair in granulosa cells by stabilizing COX5B mRNA in an m5C-dependent manner., PMID:40253045
Isoliquiritin targeting m5C RNA methylation improves mitophagy in doxorubicin-induced myocardial cardiotoxicity., PMID:39657405
The mechanism of sevoflurane affecting ovarian cancer cell proliferation and migration by regulating RNA methylase TRDMT1 to activate the β-catenin pathway., PMID:39630363
tRNA methyltransferase DNMT2 promotes hepatocellular carcinoma progression and enhances Bortezomib resistance through inhibiting TNFSF10., PMID:39617358
Exploration of the prognostic value of methylation regulators related to m5C in papillary thyroid carcinoma., PMID:38905403
Systematic Characterization of DNA Methyltransferases Family in Tumor Progression and Antitumor Immunity., PMID:38847740
Biological function molecular pathways and druggability of DNMT2/TRDMT1., PMID:38782147
Unique tRNA Fragment Upregulation with SARS-CoV-2 but Not with SARS-CoV Infection., PMID:38203569
Electromagnetic field (50 Hz) enhance metabolic potential and induce adaptive/reprogramming response mediated by the increase of N6-methyladenosine RNA methylation in adipose-derived mesenchymal stem cells in vitro., PMID:38040129
Determinants of DNMT2/TRDMT1 preference for substrates tRNA and DNA during the evolution., PMID:37966982
Role of TRDMT1/DNMT2 in stress adaptation and its influence on transcriptome and proteome dynamics under osmotic stress in Physcomitrium patens., PMID:37882266
TRDMT1-mediated RNA C-5 methylation as a novel target in anticancer therapy., PMID:37625528
Arabidopsis T-DNA mutants affected in TRDMT1/DNMT2 show differential protein synthesis and compromised stress tolerance., PMID:37584564
Restricted tRNA methylation by intermolecular disulfide bonds in DNMT2/TRDMT1., PMID:37579906
Identification and Validation of Genes Related to RNA Methylation Modification in Diabetic Retinopathy., PMID:37529844
NOP2-mediated m5C methylation of XPD is associated with hepatocellular carcinoma progression., PMID:37498063
Knockout of TRDMT1 methyltransferase affects DNA methylome in glioblastoma cells., PMID:37169948
Non-targeting siRNA-mediated responses are associated with apoptosis in chemotherapy-induced senescent skin cancer cells., PMID:36343682
DNMT2/TRDMT1 gene knockout compromises doxorubicin-induced unfolded protein response and sensitizes cancer cells to ER stress-induced apoptosis., PMID:36273376
Paternal knockdown of tRNA(cytosine-5-)-methyltransferase (Dnmt2) increases offspring susceptibility to infection in red flour beetles., PMID:35790040
TRDMT1 exhibited protective effects against LPS-induced inflammation in rats through TLR4-NF-κB/MAPK-TNF-α pathway., PMID:35474613
FMRP promotes transcription-coupled homologous recombination via facilitating TET1-mediated m5C RNA modification demethylation., PMID:35290126
Deficiency of TRDMT1 impairs exogenous RNA-based response and promotes retrotransposon activity during long-term culture of osteosarcoma cells., PMID:35104602
Position 34 of tRNA is a discriminative element for m5C38 modification by human DNMT2., PMID:34871455
The expression and clinical significance of the tRNA aspartic acid methyltransferase 1 protein in gastric cancer., PMID:34689291
Expression of different genotypes of bovine TRDMT1 gene and its polymorphisms association with body measures in Qinchuan cattle (Bos Taurus)., PMID:34629027
The lack of functional DNMT2/TRDMT1 gene modulates cancer cell responses during drug-induced senescence., PMID:34139673
New substrates and determinants for tRNA recognition of RNA methyltransferase DNMT2/TRDMT1., PMID:34110975
TRDMT1 participates in the DNA damage repair of granulosa cells in premature ovarian failure., PMID:34100772
Detection of genetic variation and activity analysis of the promoter region of the cattle tRNA-modified gene TRDMT1., PMID:34084913
Identification of the Key Regulators of Spina Bifida Through Graph-Theoretical Approach., PMID:33889172
Decoding the Genetic Alterations in Genes of DNMT Family (DNA Methyl-Transferase) and their Association with Head and Neck Squamous Cell Carcinoma., PMID:33369458
Trdmt1 3'-untranslated region functions as a competing endogenous RNA in leukemia HL-60 cell differentiation., PMID:33331537
The Roles of Host 5-Methylcytosine RNA Methyltransferases during Viral Infections., PMID:33142933
m5C modification of mRNA serves a DNA damage code to promote homologous recombination., PMID:32503981
Multiple links between 5-methylcytosine content of mRNA and translation., PMID:32293435
Depletion of TRDMT1 affects 5-methylcytosine modification of mRNA and inhibits HEK293 cell proliferation and migration., PMID:31570165
Comparative analysis of growth performance and liver transcriptome response of juvenile Ancherythroculter nigrocauda fed diets with different protein levels., PMID:31200228
Queuosine-modified tRNAs confer nutritional control of protein translation., PMID:30093495
RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia., PMID:29563491
DNA methyltransferase homologue TRDMT1 in Plasmodium falciparum specifically methylates endogenous aspartic acid tRNA., PMID:28847733
Reduced levels of methyltransferase DNMT2 sensitize human fibroblasts to oxidative stress and DNA damage that is accompanied by changes in proliferation-related miRNA expression., PMID:28843151
Cytosine methylation by DNMT2 facilitates stability and survival of HIV-1 RNA in the host cell during infection., PMID:28476776
miRSNPs of miR1274 and miR3202 Genes that Target MeCP2 and DNMT3b Are Associated with Lung Cancer Risk: A Study Conducted on MassARRAY Genotyping., PMID:27910778
The RNA methyltransferase Dnmt2 methylates DNA in the structural context of a tRNA., PMID:27819523
Dnmt2/Trdmt1 as Mediator of RNA Polymerase II Transcriptional Activity in Cardiac Growth., PMID:27270731
Mechanism and biological role of Dnmt2 in Nucleic Acid Methylation., PMID:27232191
The significance of Pax2 expression in the ureter epithelium of children with vesicoureteric reflux., PMID:25912758
Somatic cancer mutations in the DNMT2 tRNA methyltransferase alter its catalytic properties., PMID:25747896
Curcumin induces oxidation-dependent cell cycle arrest mediated by SIRT7 inhibition of rDNA transcription in human aortic smooth muscle cells., PMID:25644192
For research use only. Not for human or drug use.
