Catalog No.
YHA27401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser57-Pro200
Predicted molecular weight
18.25 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14713
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Integrin beta-1-binding protein 1, Integrin cytoplasmic domain-associated protein 1, ICAP-1, ITGB1BP1, ICAP1
Utility of an Untargeted Metabolomics Approach Using a 2D GC-GC-MS Platform to Distinguish Relapsing and Progressive Multiple Sclerosis., PMID:39330500
Utility of an untargeted metabolomics approach using a 2D GC-GC-MS platform to distinguish relapsing and progressive multiple sclerosis., PMID:38370675
ITGB1BP1, a Novel Transcriptional Target of CD44-Downstream Signaling Promoting Cancer Cell Invasion., PMID:37252376
Prognostic Value of an Integrin-Based Signature in Hepatocellular Carcinoma and the Identification of Immunological Role of LIMS2., PMID:36212176
ICAP-1 loss impairs CD8+ thymocyte development and leads to reduced marginal zone B cells in mice., PMID:35491946
Comparing Migratory and Mechanical Properties of Human Bone Marrow-Derived Mesenchymal Stem Cells with Colon Cancer Cells In Vitro., PMID:32816148
Serine phosphorylation of the small phosphoprotein ICAP1 inhibits its nuclear accumulation., PMID:32005669
Transcriptome-wide miRNA identification of Bacopa monnieri: a cross-kingdom approach., PMID:31797719
Slug and Snail have differential effects in directing colonic epithelial wound healing and partially mediate the restitutive effects of butyrate., PMID:31393789
Anti-β2 -glycoprotein I antibody with DNA binding activity enters living monocytes via cell surface DNA and induces tissue factor expression., PMID:30368780
CD31 regulates metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma via the ITGB1-FAK-Akt signaling pathway., PMID:29746931
ITGB1-dependent upregulation of Caveolin-1 switches TGFβ signalling from tumour-suppressive to oncogenic in prostate cancer., PMID:29402961
Non-catalytic region of tyrosine kinase adaptor protein 2 (NCK2) pathways as factor promoting aggressiveness in ovarian cancer., PMID:29218693
Expression of long non-coding RNA linc-ITGB1 in breast cancer and its influence on prognosis and survival., PMID:28829502
P53-induced miR-30e-5p inhibits colorectal cancer invasion and metastasis by targeting ITGA6 and ITGB1., PMID:28656629
Proteome-wide Identification of Glycosylation-dependent Interactors of Galectin-1 and Galectin-3 on Mesenchymal Retinal Pigment Epithelial (RPE) Cells., PMID:28576849
Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63-Integrin β1 Interaction., PMID:28373589
SIPA1 promotes invasion and migration in human oral squamous cell carcinoma by ITGB1 and MMP7., PMID:28237246
ICAP-1 monoubiquitylation coordinates matrix density and rigidity sensing for cell migration through ROCK2-MRCKα balance., PMID:28049720
Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus., PMID:28003363
Differential Expression of Inflammation-Related Genes in Children with Down Syndrome., PMID:27293319
hTERT mediates gastric cancer metastasis partially through the indirect targeting of ITGB1 by microRNA-29a., PMID:26903137
Integrative topological analysis of mass spectrometry data reveals molecular features with clinical relevance in esophageal squamous cell carcinoma., PMID:26898710
In vivo adhesion of malignant B cells to bone marrow microvasculature is regulated by α4β1 cytoplasmic-binding proteins., PMID:26658839
Partial least squares-based gene expression analysis in preeclampsia., PMID:26125867
Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins., PMID:25625207
The adhesive protein invasin of Yersinia pseudotuberculosis induces neutrophil extracellular traps via β1 integrins., PMID:25576025
Extravillous trophoblast-associated ADAM12 exerts pro-invasive properties, including induction of integrin beta 1-mediated cellular spreading., PMID:24695627
A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling., PMID:24044886
Cocrystal structure of the ICAP1 PTB domain in complex with a KRIT1 peptide., PMID:23695561
α1β1 integrin-mediated adhesion inhibits macrophage exit from a peripheral inflammatory lesion., PMID:23509351
Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation., PMID:23317506
Molecular markers associated with outcome and metastasis in human pancreatic cancer., PMID:22925330
Annexin A1 is associated with gastric cancer survival and promotes gastric cancer cell invasiveness through the formyl peptide receptor/extracellular signal-regulated kinase/integrin beta-1-binding protein 1 pathway., PMID:22736399
microRNA-29b contributes to pre-eclampsia through its effects on apoptosis, invasion and angiogenesis of trophoblast cells., PMID:22716646
Concepts and hypothesis: integrin cytoplasmic domain-associated protein-1 (ICAP-1) as a potential player in cerebral cavernous malformation., PMID:22711159
Phosphorylation sites in the cerebral cavernous malformations complex., PMID:22194303
Regulation of integrin activation., PMID:21663444
Gene expression profile can predict pathological response to preoperative chemoradiotherapy in rectal cancer., PMID:21471518
Effects of transfection of ICAP-1α and its mutants on adhesion and migration of 2H-11 cells., PMID:21063836
Integrin cytoplasmic domain-associated protein-1 attenuates sprouting angiogenesis., PMID:20616313
ZF21 protein regulates cell adhesion and motility., PMID:20439989
Propagation of human spermatogonial stem cells in vitro., PMID:19920237
Role of nm23 in the regulation of cell shape and migration via Rho family GTPase signals., PMID:19381785
A recurrent ITGA9 missense mutation in human fetuses with severe chylothorax: possible correlation with poor response to fetal therapy., PMID:18973153
Krit1 modulates beta 1-integrin-mediated endothelial cell proliferation., PMID:18812969
The RING domain of cIAP1 mediates the degradation of RING-bearing inhibitor of apoptosis proteins by distinct pathways., PMID:18434593
Krit 1 interactions with microtubules and membranes are regulated by Rap1 and integrin cytoplasmic domain associated protein-1., PMID:17916086
Defective osteoblast function in ICAP-1-deficient mice., PMID:17567669
From the membrane to the nucleus and back again: bifunctional focal adhesion proteins., PMID:16908128
For research use only. Not for human or drug use.
