Catalog No.
PHA43201
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human MDM4 (Thr2-Asp134).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
MDM4, Mdm2-like p53-binding protein, MDMX, p53-binding protein Mdm4, Protein Mdm4, Protein Mdmx, Double minute 4 protein
Concentration
1.3 mg/ml
Purification
Purified by antigen affinity column.
Accession
O15151
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
First reported advanced pancreatic cancer with hyperprogression treated with PD-1 blockade combined with chemotherapy: a case report and literature review., PMID:39404967
Identification of GPC3 mutation and upregulation in a multidrug resistant osteosarcoma and its spheroids as therapeutic target., PMID:34611509
p53 Activation Effect in the Balance of T Regulatory and Effector Cell Subsets in Patients With Thyroid Cancer and Autoimmunity., PMID:34539667
ModiBodies: A computational method for modifying nanobodies in nanobody-antigen complexes to improve binding affinity and specificity., PMID:32418062
Mdm2: Open questions., PMID:32335977
Hyperprogression and Immunotherapy: Fact, Fiction, or Alternative Fact?, PMID:32101722
Hyperprogressors after Immunotherapy: Analysis of Genomic Alterations Associated with Accelerated Growth Rate., PMID:28351930
Mouse Double Minute 2 Actively Suppresses p53 Activity in Oocytes during Mouse Folliculogenesis., PMID:27912078
UXT, a novel MDMX-binding protein, promotes glycolysis by mitigating p53-mediated restriction of NF-κB activity., PMID:25974965
Prevalence and clinical implications of cyclin D1 expression in diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy: a report from the International DLBCL Rituximab-CHOP Consortium Program., PMID:24648050
The fluorescent two-hybrid assay to screen for protein-protein interaction inhibitors in live cells: targeting the interaction of p53 with Mdm2 and Mdm4., PMID:24476585
Ubiquitin-specific protease 2a stabilizes MDM4 and facilitates the p53-mediated intrinsic apoptotic pathway in glioblastoma., PMID:24445145
Targeted therapy: tailoring cancer treatment., PMID:23823626
High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphoma., PMID:19759907
Structure of human MDM4 N-terminal domain bound to a single-domain antibody., PMID:19084022
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage., PMID:16163388
For research use only. Not for human or drug use.
