Catalog No.
YMA35901
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Gly19-Leu151
Predicted molecular weight
17.08 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O88803
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Leukocyte cell-derived chemotaxin-2, LECT-2, Chondromodulin II, ChM-II, Lect2
LPS stimulation-induced regulation of LECT2 expression via TLR4 in hepatocytes., PMID:40495481
Protein misfolding, aggregation and factors determining the amyloidogenic landscape of human leucocyte chemotaxin-2: A review., PMID:40490246
Renal Leukocyte Chemotactic Factor 2 (ALECT2) Amyloidosis With Concurrent IgA Nephropathy: A Case Report and Literature Review., PMID:40443630
The role of LECT2 in kidney fibrosis progression and endoplasmic reticulum stress., PMID:40398731
Plasma Leukocyte Cell-Derived Chemotaxin-2 as a Risk Factor of Sarcopenia: Korean Frailty and Aging Cohort Study., PMID:40284206
Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2., PMID:40139745
Leukocyte cell-derived chemotaxin 2 (LECT2) regulates liver ischemia-reperfusion injury., PMID:39957753
miR-328-3p suppresses hepatocellular carcinoma progression by regulating HMOX1 expression., PMID:39617834
Hepatokine leukocyte cell-derived chemotaxin 2 as a biomarker of insulin resistance, liver enzymes, and metabolic dysfunction-associated steatotic liver disease in the general population., PMID:39570764
Discovery of novel obesity genes through cross-ancestry analysis., PMID:39484254
A blood-based PT-LIFE (Pediatric Liver Transplantation-LIver Fibrosis Evaluation) biomarker panel for noninvasive evaluation of pediatric liver fibrosis after liver transplantation: A prospective derivation and validation study., PMID:39447750
Kidney Disease in Systemic Amyloidosis: A Review of Amyloid, Amyloid Serum A Protein, Leukocyte Chemotactic Factor 2, and Transthyretin Amyloid., PMID:39356570
Role of LECT2 in exacerbating atopic dermatitis: insight from in vivo and in vitro models via NF-κB signaling pathway., PMID:39206203
[Renal leukocyte chemokine type 2 amyloidosis: a clinicopathological analysis of fifteen cases]., PMID:39103262
Updates on the role of leukocyte cell-derived chemotaxin-2 in inflammation regulation and immunomodulation., PMID:39024680
LECT2 mediates antibacterial immune response induced by Nocardia seriolae infection in the northern snakehead., PMID:38908810
Global research trends and hotspots for leukocyte cell-derived chemotaxin-2 from the past to 2023: a combined bibliometric review., PMID:38881894
Kidney Amyloidosis: Updates on Pathogenesis and Therapeutic Frontiers., PMID:38865984
Inflammatory markers as diagnostic and precision nutrition tools for metabolic dysfunction-associated steatotic liver disease: Results from the Fatty Liver in Obesity trial., PMID:38861890
LECT2 Deletion Exacerbates Liver Steatosis and Macrophage Infiltration in a Male Mouse Model of LPS-mediated NASH., PMID:38781447
ALECT2 amyloidosis with concurrent IgG4-related interstitial nephritis, membranous nephropathy and diabetic kidney disease: a case report and literature review., PMID:38630340
Mimicking kidney flow shear efficiently induces aggregation of LECT2, a protein involved in renal amyloidosis., PMID:38537700
2024 Update on Classification, Etiology, and Typing of Renal Amyloidosis: A Review., PMID:38514011
Morphological findings in different subtypes of hepatic amyloid., PMID:38460799
Possible transmission of leukocyte chemotactic factor 2 amyloidosis after interpopulational liver transplantation., PMID:38444123
Elevated serum levels of leukocyte cell-derived chemotaxin 2 are associated with the prevalence of metabolic syndrome., PMID:38383671
Elucidation of pericholangitis and periductal fibrosis in cholestatic liver diseases via extracellular vesicles released by polarized biliary epithelial cells., PMID:38344767
Loss of LECT2 promotes ovarian cancer progression by inducing cancer invasiveness and facilitating an immunosuppressive environment., PMID:38177412
Association between Leukocyte Cell-Derived Chemotaxin 2 and Metabolic and Renal Diseases in a Geriatric Population: A Pilot Study., PMID:38137613
PFOS-elicited metabolic perturbation in liver and fatty acid metabolites in testis of adult mice., PMID:38075064
Antimicrobial Protein LECT2-b Helps Maintain Gut Microbiota Homeostasis via Selectively Targeting Certain Pathogenic Bacteria., PMID:38038392
Relationship between the changes in hepatokine levels and metabolic effects after laparoscopic sleeve gastrectomy in severely obese patients., PMID:37957316
Leukocyte cell-derived chemotaxin 2 correlates with pediatric non-alcoholic fatty liver disease., PMID:37877453
Convertase-dependent regulation of membrane-tethered and secreted ligands tunes dendrite adhesion., PMID:37721334
Cryo-EM structure of a human LECT2 amyloid fibril reveals a network of polar ladders at its core., PMID:37657439
The signature of cuproptosis-related immune genes predicts the tumor microenvironment and prognosis of prostate adenocarcinoma., PMID:37600770
[Research progress of the regulation of orphan nuclear receptors on chronic liver diseases]., PMID:37583043
Urinary Proteomics for Discovery of Gastric Cancer Biomarkers to Enable Precision Clinical Oncology., PMID:37579183
Mimicking Kidney Flow Shear Efficiently Induces Aggregation of LECT2, a Protein Involved in Renal Amyloidosis., PMID:37503176
The emerging roles of leukocyte cell-derived chemotaxin-2 in immune diseases: From mechanisms to therapeutic potential., PMID:36969200
Inflammation-related mRNA expression in patients with multiple myeloma undergoing hematopoietic stem cell mobilization., PMID:36906219
Circulating leukocyte cell-derived chemotaxin 2 and fibroblast growth factor 21 are negatively associated with cardiorespiratory fitness in healthy volunteers., PMID:36867855
Cryo-EM Structure of a Human LECT2 Amyloid Fibril Reveals a Network of Polar Ladders at its Core., PMID:36798409
LECT2 modulates dendritic cell function after Helicobacter pylori infection via the CD209a receptor., PMID:36740832
β-catenin/TCF4 inhibitors ICG-001 and LF3 alleviate BDL-induced liver fibrosis by suppressing LECT2 signaling., PMID:36639009
Liver infiltration of multiple immune cells during the process of acute liver injury and repair., PMID:36569272
Whole-exome sequence analysis of anthropometric traits illustrates challenges in identifying effects of rare genetic variants., PMID:36568030
Leukocyte Chemotactic Factor 2 Amyloidosis (ALECT2) Distribution in a Mexican Population., PMID:36370056
Concurrence of leukocyte chemotactic factor 2-associated amyloidosis and autoimmune diseases: A case report., PMID:36059556
Leukocyte cell-derived chemotaxin 2 regulates epithelial-mesenchymal transition and cancer stemness in hepatocellular carcinoma., PMID:36055405
For research use only. Not for human or drug use.
