Catalog No.
YHG63401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser389
Predicted molecular weight
45.99 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13686
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ALKBH1, DNA lyase ABH1, Alpha-ketoglutarate-dependent dioxygenase ABH1, ABH, ALKBH, Nucleic acid dioxygenase ALKBH1, DNA 6mA demethylase, Alkylated DNA repair protein alkB homolog 1, ABH1, DNA N6-methyl adenine demethylase ALKBH1, mRNA N(3)-methylcytidine demethylase, DNA oxidative demethylase ALKBH1
Evaluated NSUN3 in reticulocytes from HbH-CS disease that reflects cellular stress in erythroblasts., PMID:40240513
The role of cholesterol/ALKBH1/ITGA2B in thrombosis in the placental vessels of preeclampsia., PMID:40156099
ALKBH1 knockdown promotes the growth, migration and invasion of HTR-8/SVneo cells through regulating the m5C modification PSMD14., PMID:40025166
Correction to: ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells., PMID:39970274
m1A regulator‑mediated methylation modifications and gene signatures and their prognostic value in multiple myeloma., PMID:39624591
Structural Optimization and Structure-Activity Relationship of 1H-Pyrazole-4-carboxylic Acid Derivatives as DNA 6mA Demethylase ALKBH1 Inhibitors and Their Antigastric Cancer Activity., PMID:39225755
The Role of RNA m5C Modification in Central Nervous System Diseases., PMID:39190372
Unveiling the molecular complexity of proliferative diabetic retinopathy through scRNA-seq, AlphaFold 2, and machine learning., PMID:38800474
Kinetic Studies on the 2-Oxoglutarate/Fe(II)-Dependent Nucleic Acid Modifying Enzymes from the AlkB and TET Families., PMID:38698914
ALKBH1 promotes HIF-1α-mediated glycolysis by inhibiting N-glycosylation of LAMP2A., PMID:38472355
Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demethylase ALKBH1., PMID:38437718
Depletion of the m1A writer TRMT6/TRMT61A reduces proliferation and resistance against cellular stress in bladder cancer., PMID:38304034
Research progress of N1-methyladenosine RNA modification in cancer., PMID:38291517
ALYREF (Aly/REF export factor): A potential biomarker for predicting cancer occurrence and therapeutic efficacy., PMID:38135116
Dengue virus exploits the host tRNA epitranscriptome to promote viral replication., PMID:37986976
Chemoproteomic Approaches to Studying RNA Modification-Associated Proteins., PMID:37733063
A DNA adenine demethylase impairs PRC2-mediated repression of genes marked by a specific chromatin signature., PMID:37649077
Predicting response of immunotherapy and targeted therapy and prognosis characteristics for renal clear cell carcinoma based on m1A methylation regulators., PMID:37542141
Xiao Chai Hu Tang alleviates the pancreatic tumorigenesis via improving the mtDNA N6-Methyladenine modification mediated mitochondrial dysfunction in Syrian hamster model., PMID:37172477
Sirtuin4 impacts mitochondrial homeostasis in pancreatic cancer cells by reducing the stability of AlkB homolog 1 via deacetylation of the HRD1-SEL1L complex., PMID:37146713
The N6-methyladenine DNA demethylase ALKBH1 promotes gastric carcinogenesis by disrupting NRF1 binding capacity., PMID:36989111
DNA 6mA demethylase ALKBH1 regulates DDX18 expression to promote proliferation of human head and neck squamous cell carcinoma., PMID:36976498
ALKBH1 contributes to renal cell carcinoma progression by reducing N6-methyladenine of GPR137., PMID:36920340
U-shaped association between serum IGF2BP3 and T2DM: A cross-sectional study in Chinese population., PMID:36891946
ALKBH1-mediated m1 A demethylation of METTL3 mRNA promotes the metastasis of colorectal cancer by downregulating SMAD7 expression., PMID:36550779
N1-methyladenosine modification in cancer biology: Current status and future perspectives., PMID:36467585
Selected ALKBH dioxygenases are overexpressed in salivary gland tumours., PMID:36459535
Expression of m6A Methylation Regulator in Osteoarthritis and Its Prognostic Markers., PMID:36443992
N6-methyladenine: A Rare and Dynamic DNA Mark., PMID:36350511
TRAT1 overexpression delays cancer progression and is associated with immune infiltration in lung adenocarcinoma., PMID:36276113
DNA 6mA Demethylase ALKBH1 Orchestrates Fatty Acid Metabolism and Suppresses Diet-Induced Hepatic Steatosis., PMID:36058506
Tyrosyl-DNA phosphodiesterase 1 excises the 3'-DNA-ALKBH1 cross-link and its application for 3'-DNA-ALKBH1 cross-link characterization by LC-MS/MS., PMID:36049356
ALKBH family members as novel biomarkers and prognostic factors in human breast cancer., PMID:35980268
Reactivity-dependent profiling of RNA 5-methylcytidine dioxygenases., PMID:35853884
Gene Polymorphisms of m6A Erasers FTO and ALKBH1 Associated with Susceptibility to Gastric Cancer., PMID:35669943
Characterization of the prognostic and diagnostic values of ALKBH family members in non-small cell lung cancer., PMID:35180653
The enhanced genomic 6 mA metabolism contributes to the proliferation and migration of TSCC cells., PMID:35177638
DNA N6-methyladenine involvement and regulation of hepatocellular carcinoma development., PMID:35032618
Alkbh1-mediated DNA N6-methyladenine modification regulates bone marrow mesenchymal stem cell fate during skeletal aging., PMID:35018683
DNA demethylase ALKBH1 promotes adipogenic differentiation via regulation of HIF-1 signaling., PMID:34922943
Single-Base Resolution Mapping Reveals Distinct 5-Formylcytidine in Saccharomyces cerevisiae mRNAs., PMID:34846122
DNA Methylation on N6-Adenine Regulates the Hyphal Development during Dimorphism in the Early-Diverging Fungus Mucor lusitanicus., PMID:34575776
MicroRNA-3935 promotes human trophoblast cell epithelial-mesenchymal transition through tumor necrosis factor receptor-associated factor 6/regulator of G protein signaling 2 axis., PMID:34493304
Human HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts., PMID:34391879
D-2-hydroxyglutarate dehydrogenase in breast carcinoma as a potent prognostic marker associated with proliferation., PMID:34296423
ALKBH1 reduces DNA N6-methyladenine to allow for vascular calcification in chronic kidney disease., PMID:34263739
Demethyltransferase AlkBH1 substrate diversity and relationship to human diseases., PMID:34046849
ALKBH1-demethylated DNA N6-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease., PMID:34003800
Telencephalon-specific Alkbh1 conditional knockout mice display hippocampal atrophy and impaired learning., PMID:33930188
Genetic characteristics and prognostic implications of m1A regulators in pancreatic cancer., PMID:33779693
For research use only. Not for human or drug use.
