Catalog No.
YHA20301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser114-Asn374
Predicted molecular weight
31.02 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O14511
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Pro-neuregulin-2, membrane-bound isoform, Pro-NRG2, Neuregulin-2, NRG-2, Divergent of neuregulin-1, DON-1, Neural- and thymus-derived activator for ERBB kinases, NTAK, NRG2, NTAK
Based on two coconut (Cocos nucifera L.) genome-wide investigation of NODULE-INCEPTION-like protein family: evolution and expression profiles during development and stress., PMID:40308303
Upstream-binding protein-1 promotes breast tumorigenesis by inducing NRG2-mediated metastasis, plasticity, and macrophage polarization., PMID:40064277
Repair Assisted Damage Detection (RADD) as a predictive biomarker for immunotherapy response in ovarian cancer., PMID:39546931
Neuregulin 2 Is a Candidate Gene for Autism Spectrum Disorder., PMID:38791584
Prognostic biomarker NRG2 correlates with autophagy and epithelial‑mesenchymal transition in breast cancer., PMID:38699660
NRG2 family members of Arabidopsis and maize regulate nitrate signalling and promote nitrogen use efficiency., PMID:38472740
ERBB4-Mediated Signaling Is a Mediator of Resistance to PI3K and BTK Inhibitors in B-cell Lymphoid Neoplasms., PMID:38052765
Neo-functionalization in Saccharomyces cerevisiae: a novel Nrg1-Rtg3 chimeric transcriptional modulator is essential to maintain mitochondrial DNA integrity., PMID:37920568
A molecular framework underlying low-nitrogen-induced early leaf senescence in Arabidopsis thaliana., PMID:36906802
ER-PM Junctions on GABAergic Interneurons Are Organized by Neuregulin 2/VAP Interactions and Regulated by NMDA Receptors., PMID:36769244
The relevance of EGFR, ErbB receptors and neuregulins in human adipocytes and adipose tissue in obesity., PMID:36411648
Plasma PFOA and PFOS Levels, DNA Methylation, and Blood Lipid Levels: A Pilot Study., PMID:36374530
Age-associated changes in gene expression in the anterior pituitary glands of female Japanese black cattle., PMID:35838775
Identification of an Autophagy-Related Signature Based on Whole Bone Marrow Sequencing for the Prognosis and Immune Microenvironment Characterization of Multiple Myeloma., PMID:35677537
Circulating Tumor Cell-Free DNA Genes as Prognostic Gene Signature for Platinum Resistant Ovarian Cancer Diagnosis., PMID:35370397
NRG1 and NRG2 fusion positive solid tumor malignancies: a paradigm of ligand-fusion oncogenesis., PMID:34996744
The N-terminally truncated helper NLR NRG1C antagonizes immunity mediated by its full-length neighbors NRG1A and NRG1B., PMID:34871452
NRG1 and NRG2 fusions in non-small cell lung cancer (NSCLC): seven years between lights and shadows., PMID:34706602
[Neuregulin 2 is highly expressed in glioma tissues to regulate glial fibrillary acidic protein expression via Akt signaling]., PMID:34549707
Identification of tissue-specific and common methylation quantitative trait loci in healthy individuals using MAGAR., PMID:34530905
Neuregulin 2 (NRG2) is expressed in gliomas and promotes migration of human glioma cells., PMID:34284546
Development and validation of a survival model for esophageal adenocarcinoma based on autophagy-associated genes., PMID:34252349
Dopamine System, NMDA Receptor and EGF Family Expressions in Brain Structures of Bl6 and 129Sv Strains Displaying Different Behavioral Adaptation., PMID:34072341
Low-level embryonic crude oil exposure disrupts ventricular ballooning and subsequent trabeculation in Pacific herring., PMID:33823483
Development and application of high-throughput screens for the discovery of compounds that disrupt ErbB4 signaling: Candidate cancer therapeutics., PMID:33378376
Investigating the Transition of Pre-Symptomatic to Symptomatic Huntington's Disease Status Based on Omics Data., PMID:33049985
Neuregulins 1, 2, and 3 Promote Early Neurite Outgrowth in ErbB4-Expressing Cortical GABAergic Interneurons., PMID:32542595
Regenerative potential of prostate luminal cells revealed by single-cell analysis., PMID:32355025
The dichotomous role of epiregulin in pain., PMID:31917773
Temporal Dynamics of the Neuregulin-ErbB Network in the Murine Prefrontal Cortex across the Lifespan., PMID:31897479
Proteolytic Processing of Neuregulin 2., PMID:31838721
NMDA Receptors Regulate Neuregulin 2 Binding to ER-PM Junctions and Ectodomain Release by ADAM10 [corrected]., PMID:31240601
Identification a novel set of 6 differential expressed genes in prostate cancer that can potentially predict biochemical recurrence after curative surgery., PMID:30637711
Developmental expression of Neuregulin-3 in the rat central nervous system., PMID:30328115
Isoform-specific cleavage of neuroligin-3 reduces synapse strength., PMID:30242227
Peripheral Transcription of NRG-ErbB Pathway Genes Are Upregulated in Treatment-Resistant Schizophrenia., PMID:29163244
Structural Similarities between Neuregulin 1-3 Isoforms Determine Their Subcellular Distribution and Signaling Mode in Central Neurons., PMID:28432142
Neuregulin-2 ablation results in dopamine dysregulation and severe behavioral phenotypes relevant to psychiatric disorders., PMID:28322273
Identification of Neuregulin-2 as a novel stress granule component., PMID:27345716
Specific inhibition of secreted NRG1 types I-II by heparin enhances Schwann Cell myelination., PMID:27143444
NTAK/neuregulin-2 secreted by astrocytes promotes survival and neurite outgrowth of neurons via ErbB3., PMID:27113200
Downregulation of epidermal growth factor receptor family receptors and ligands in a mutant K-ras group of patients with colorectal cancer., PMID:26935861
The Arabidopsis NRG2 Protein Mediates Nitrate Signaling and Interacts with and Regulates Key Nitrate Regulators., PMID:26744214
Bidirectional Signaling of Neuregulin-2 Mediates Formation of GABAergic Synapses and Maturation of Glutamatergic Synapses in Newborn Granule Cells of Postnatal Hippocampus., PMID:26674872
A negative feedback loop controls NMDA receptor function in cortical interneurons via neuregulin 2/ErbB4 signalling., PMID:26027736
YAP forms autocrine loops with the ERBB pathway to regulate ovarian cancer initiation and progression., PMID:25798835
Epithelial TRPV1 signaling accelerates gingival epithelial cell proliferation., PMID:25266715
Coregulated expression of the Na+/phosphate Pho89 transporter and Ena1 Na+-ATPase allows their functional coupling under high-pH stress., PMID:25266663
Gene expression in hippocampus as a function of differential trait anxiety levels in genetically heterogeneous NIH-HS rats., PMID:24095878
Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study., PMID:23912956
For research use only. Not for human or drug use.
